Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Medicine Reports

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/mmr_00000161PMID 21475890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

  2008cited by this paper
• Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

  2007cited by this paper
• Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors*

  2006cited by this paper
• Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma.

  2006cited by this paper
• Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3.

  2006cited by this paper
• Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.

  2006cited by this paper
• IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.

  2005cited by this paper
• MHC class II‐expressing hepatocytes function as antigen‐presenting cells and activate specific CD4 T lymphocyutes

  2003cited by this paper
• The clinical significance of cathepsin S expression in human astrocytomas.

  2003cited by this paper
• Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis

  2001cited by this paper
• Expression of Rat Cathepsin S in Phagocytic Cells (*)

  1996cited by this paper
• Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

  1995cited by this paper
• Identification of hepatocytes as the major locus of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1-related P450s, TCDDAA and TCDDAHH, in chick embryo liver.

  1994cited by this paper

• CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis

  2025cites this paper
• Cathepsin S regulates ferroptosis sensitivity in hepatocellular carcinoma through the KEAP1-NRF2 signaling pathway

  2025cites this paper
• Extracellular Cathepsin B Is a Potential Therapeutic Target in Hepatocellular Carcinoma

  2025cites this paper
• Cysteine Cathepsins: From Diagnosis to Targeted Therapy of Cancer.

  2024cites this paper
• Assessment of the diagnostic value of serum cathepsin S and its correlation with HDL subclasses in patients with non-Hodgkin's lymphoma

  2024cites this paper
• Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple‐negative breast cancer cells

  2024cites this paper
• The current landscape of the antimicrobial peptide melittin and its therapeutic potential

  2024cites this paper
• Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

  2024cites this paper
• The impact of cathepsins on liver hepatocellular carcinoma: Insights from genetic and functional analyses.

  2024cites this paper
• Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins

  2024cites this paper
• Evaluation of serum levels of cathepsin S among colorectal cancer patients

  2022cites this paper
• All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma

  2022cites this paper
• New Shining Stars in The Sky of Breast Cancer Diagnosis and Prognosis: A Review

  2022cites this paper
• Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential.

  2022cites this paper
• Dihydrochalcones as antitumor agents.

  2022cites this paper
• Anti-hepatic fibrosis effects of AD-2 affecting the Raf-MEK signaling pathway and inflammatory factors in thioacetamide-induced liver injury.

  2021cites this paper
• An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi—A Comparison of Analytical Properties of Silver–Gold and Pure Gold Chips

  2021cites this paper
• The multifaceted role of cathepsins in liver disease.

  2021cites this paper
• Two SPRi biosensors for the determination of cathepsin S in blood plasma.

  2021cites this paper
• Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery

  2020cites this paper
• Leading the invasion: The role of Cathepsin S in the tumour microenvironment.

  2020cites this paper
• A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

  2019cites this paper
• Inhibitory Covalent Labeling and Clickable-Eu-Tagging-Based ICPMS: Measurement of pH-Dependent Absolute Activities of the Cathepsins in Hepatocyte Lysosomes.

  2019cites this paper
• Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.

  2019cites this paper
• Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.

  2019cites this paper
• Gene expression profiling of humans under exertional heat stress: Comparisons between persons with and without exertional heat stroke.

  2019cites this paper
• The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 431

  2019cites this paper
• Long-term endurance training increases serum cathepsin S levels in healthy female subjects

  2018cites this paper
• Cysteine cathepsins as a prospective target for anticancer therapies-current progress and prospects.

  2018cites this paper
• Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour-Associated Macrophages

  2018cites this paper
• Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression.

  2018cites this paper
• Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress

  2018cites this paper
• Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP

  2017cites this paper
• Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways

  2017cites this paper
• Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer

  2016cites this paper
• A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

  2016cites this paper
• TAP‐mediated processing of exoerythrocytic antigens is essential for protection induced with radiation‐attenuated Plasmodium sporozoites

  2016cites this paper
• Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors

  2016cites this paper
• Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells

  2015cites this paper
• Cathepsin S as a cancer target.

  2015cites this paper
• Lysosomal cysteine peptidases - Molecules signaling tumor cell death and survival.

  2015cites this paper
• Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells.

  2015cites this paper
• Cathepsin S: therapeutic, diagnostic, and prognostic potential

  2015cites this paper
• Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma

  2015cites this paper
• Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors.

  2015cites this paper
• Role of lysosomes in cancer therapy

  2015cites this paper
• Cathepsin S as a cancer target Minireview

  2014cites this paper
• Autophagy induced by cathepsin S inhibition induces early ROS production, oxidative DNA damage, and cell death via xanthine oxidase.

  2013cites this paper
• Antibody research targeting Cathepsin S for cancer therapy

  2013cites this paper
• Proteases in Cancer: Significance for Invasion and Metastasis

  2013cites this paper
• Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.

  2012cites this paper
• The Emerging Relevance of the Cysteine Protease Cathepsin S in Disease

  2011cites this paper
• The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

  2011cites this paper