Genome-Wide Identification of Novel Genes Involved in Early Th1 and Th2 Cell Differentiation1

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Immunology

• Publication date

  2007-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.178.6.3648PMID 17339462
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation.

  2006cited by this paper
• Identification of genes involved in the initiation of human Th1 or Th2 cell commitment

  2005cited by this paper
• Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation.

  2004cited by this paper
• N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

  2004cited by this paper
• Kinetics and STAT4‐ or STAT6‐mediated regulation of genes involved in lymphocyte polarization to Th1 and Th2 cells

  2003cited by this paper
• Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways

  2003cited by this paper
• Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL‐12 responses

  2003cited by this paper
• Cloning and Characterization of N4WBP5A, an Inducible, Cyclosporine-sensitive, Nedd4-binding Protein in Human T Lymphocytes*

  2003cited by this paper
• SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses

  2003cited by this paper
• Identification of Novel Genes Regulated by IL-12, IL-4, or TGF-β during the Early Polarization of CD4+ Lymphocytes 1

  2003cited by this paper
• NetAffx: Affymetrix probesets and annotations

  2003cited by this paper
• Identification of Novel IL-4/Stat6-Regulated Genes in T Lymphocytes1

  2003cited by this paper
• Cytokine Coexpression During Human Th1/Th2 Cell Differentiation: Direct Evidence for Coordinated Expression of Th2 Cytokines1

  2002cited by this paper
• Heterotrimeric G protein signaling: role in asthma and allergic inflammation.

  2002cited by this paper
• Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation

  2002cited by this paper
• T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

  2002cited by this paper
• Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

  2002cited by this paper
• Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

  2001cited by this paper
• Distinct gene expression profiles of human type 1 and type 2 T helper cells

  2001cited by this paper
• T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

  2001cited by this paper
• Comprehensive gene expression profile of human activated T(h)1- and T(h)2-polarized cells.

  2001cited by this paper
• Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection

  2001cited by this paper
• Gene Microarrays Reveal Extensive Differential Gene Expression in Both CD4+ and CD8+ Type 1 and Type 2 T Cells1

  2001cited by this paper
• Identification and validation of endogenous reference genes for expression profiling of T helper cell differentiation by quantitative real-time RT-PCR.

  2001cited by this paper
• A novel transcription factor, T-bet, directs Th1 lineage commitment.

  2000cited by this paper
• Lineage commitment in the immune system: the T helper lymphocyte grows up.

  2000influential reference
• Interferon γ Signaling Alters the Function of T Helper Type 1 Cells

  2000cited by this paper
• T Cell Receptor–Induced Calcineurin Activation Regulates T Helper Type 2 Cell Development by Modifying the Interleukin 4 Receptor Signaling Complex

  2000cited by this paper
• CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors1

  2000cited by this paper
• Touching base

  2000cited by this paper
• Selective export of MHC class I molecules from the ER after their dissociation from TAP.

  2000cited by this paper
• T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.

  1999cited by this paper
• Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.

  1999cited by this paper
• Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.

  1997cited by this paper
• Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*

  1997cited by this paper
• The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.

  1997cited by this paper
• What controls tissue-specific expression of the IL-4 gene?

  1997cited by this paper
• Interferon‐γ and interleukin‐4 regulate T cell interleukin‐12 responsiveness through the differential modulation of high‐affinity interleukin‐12 receptor expression

  1997cited by this paper
• Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

  1996cited by this paper
• Th1 and Th2 in human diseases.

  1996influential reference
• Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

  1996cited by this paper
• A direct role for IFN-gamma in regulation of Th1 cell development.

  1996cited by this paper
• Isolation and characterization of fra-2, an additional member of the fos gene family.

  1990cited by this paper
• © 1999 The Japanese Society for Immunology Specific regulation of Fos family

  year unknowncited by this paper

• Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies

  2024cites this paper
• Differentiation and Regulation of Bovine Th2 Cells In Vitro

  2024cites this paper
• Role of AMIGO2 in cancer progression: Novel insights (Review)

  2024cites this paper
• A Proteomics-Based Approach Identifies the NEDD4 Adaptor NDFIP2 as an Important Regulator of Ifitm3 Levels

  2023cites this paper
• In memory of Professor Iain Wilkinson: cognitive and neuroimaging endophenotypes in a consanguineous schizophrenia multiplex family

  2022cites this paper
• A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation

  2022cites this paper
• Association Study of NDFIP2 Genetic Polymorphism with Asthma in the Korean Population

  2021cites this paper
• Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation

  2021cites this paper
• Sex‐specific associations of asthma acquisition with changes in DNA methylation during adolescence

  2020cites this paper
• A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia

  2020cites this paper
• CD4 T Helper Cell Subsets and Related Human Immunological Disorders

  2020cites this paper
• Pathogenetic profiling of COVID-19 and SARS-like viruses

  2020cites this paper
• The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.

  2020cites this paper
• Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing

  2020influential citation
• Genome‐wide search for genes affecting the age at diagnosis of type 1 diabetes

  2020cites this paper
• Understanding the hidden relations between pro- and anti-inflammatory cytokine genes in bovine oviduct epithelium using a multilayer response surface method

  2019cites this paper
• Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals Novel Signatures of Gene Expression and Splicing

  2019influential citation
• Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

  2018cites this paper
• Activated β-Catenin in Foxp3+ Regulatory T cells Links Inflammatory Environments to Autoimmunity

  2018cites this paper
• PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3+ Regulatory T cells

  2018cites this paper
• A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep

  2018cites this paper
• Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype

  2017cites this paper
• AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis.

  2017cites this paper
• Impact of Enriched Environment on Murine T Cell Differentiation and Gene Expression Profile

  2016cites this paper
• Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

  2016cites this paper
• Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy.

  2016cites this paper
• Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

  2016cites this paper
• Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

  2016cites this paper
• Identification of global regulators of T-helper cell lineage specification

  2015cites this paper
• Modulation of host ubiquitin system genes in human endometrial cell line infected with Mycobacterium tuberculosis

  2015cites this paper
• Roles of Id3 and IL-13 in a Mouse Model of Autoimmune Exocrinopathy

  2015cites this paper
• Host response to leptospira infection.

  2015cites this paper
• FRA2 Is a STAT5 Target Gene Regulated by IL-2 in Human CD4 T Cells

  2014cites this paper
• Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise

  2014cites this paper
• E proteins in lymphocyte development and lymphoid diseases.

  2014cites this paper
• Boolean modeling: a logic‐based dynamic approach for understanding signaling and regulatory networks and for making useful predictions

  2014cites this paper
• Transcriptional and epigenetic regulation of T-helper lineage specification

  2014cites this paper
• Holistic Systems Biology Approaches to Molecular Mechanisms of Human Helper T Cell Differentiation to Functionally Distinct Subsets

  2013cites this paper
• Transcription factor interplay in T helper cell differentiation

  2013cites this paper
• The Facial Evolution: Looking Backward and Moving Forward

  2013cites this paper
• PARP-14 Binds Specific DNA Sequences to Promote Th2 Cell Gene Expression

  2013cites this paper
• Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

  2013cites this paper
• From a gene-centric to whole-proteome view of differentiation of T helper cell subsets

  2013cites this paper
• T-cell activation induces selective changes of cellular lipidome.

  2013cites this paper
• Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes

  2013cites this paper
• Induction of appropriate Th‐cell phenotypes: cellular decision‐making in heterogeneous environments

  2013cites this paper
• Regulation of lymphocyte response in vitro and in vivo

  2013cites this paper
• Boolean modeling of biological regulatory networks: a methodology tutorial.

  2013cites this paper
• Early T helper cell programming of gene expression in human.

  2013cites this paper
• Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.

  2013cites this paper
• An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

  2012cites this paper
• 3D facial analysis can investigate vaccine responses.

  2012cites this paper
• Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis

  2012cites this paper
• Impairment of hepatic NK cell development in IFN-γ deficient mice.

  2012cites this paper
• Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation

  2012cites this paper
• System-wide approaches to uncover Th2 cell lineage commitment

  2012cites this paper
• Exon Level Transcriptomic Profiling of HIV-1-Infected CD4+ T Cells Reveals Virus-Induced Genes and Host Environment Favorable for Viral Replication

  2012cites this paper
• Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3

  2011cites this paper
• Intersections of Epigenetics, Twinning and Developmental Asymmetries: Insights Into Monogenic and Complex Diseases and a Role for 3D Facial Analysis

  2011cites this paper
• Combining Network Modeling and Gene Expression Microarray Analysis to Explore the Dynamics of Th1 and Th2 Cell Regulation

  2010cites this paper
• Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

  2010influential citation
• Identification of helper T cell master regulator candidates using the polar score method.

  2010cites this paper
• Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4+ Cells in the Early Phases of IL-4-induced Th2 Differentiation

  2010cites this paper
• Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.

  2010cites this paper
• SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

  2010cites this paper
• A phylogenetic approach to gene expression data: evidence for the evolutionary origin of mammalian leukocyte phenotypes

  2009cites this paper
• Current research status of immunology in the genomic era

  2009cites this paper
• Profiling of the early transcriptional response of murine gammadelta T cells following TCR stimulation.

  2009cites this paper
• Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm.

  2009cites this paper
• A Network Modeling Approach to Analysis of the Th2 Memory Responses Underlying Human Atopic Disease1

  2009cites this paper
• Quantitative Proteomics Reveals GIMAP Family Proteins 1 and 4 to Be Differentially Regulated during Human T Helper Cell Differentiation *S

  2009cites this paper
• Allergen Challenge Induces Ifng Dependent GTPases in the Lungs as Part of a Th1 Transcriptome Response in a Murine Model of Allergic Asthma

  2009cites this paper
• QUANTITATIVE PROTEOMICS IN THE CHARACTERIZATION OF T HELPER LYMPHOCYTE DIFFERENTIATION

  2008cites this paper
• Molecular epigenetics, chromatin, and NeuroAIDS/HIV: Immunopathological implications

  2008cites this paper
• Genome-wide expression profiling of T-cells in childhood wheeze

  2008cites this paper
• An insight into molecular mechanisms of human T helper cell differentiation

  2008cites this paper
• Investigation of the Role of Cholera Toxin in Assisting the Initiation of the Antigen-Specific Th2 Response

  2008cites this paper
• REGULATORY MECHANISMS INVOLVED IN TH2 CELL DIFFERENTIATION

  2007influential citation