The function of tyrosine hydroxylase in the normal and Parkinsonian brain.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  CNS and Neurological Disorders - Drug Targets

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/187152712800792794PMID 22483314
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Iron dysregulation in movement disorders.

  2012cited by this paper
• Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation

  2011cited by this paper
• The nonmotor symptoms of Parkinson's disease—An overview

  2010cited by this paper
• Gene Therapy in Parkinson’s Disease

  2010cited by this paper
• Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.

  2010cited by this paper
• Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

  2009cited by this paper
• Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

  2008cited by this paper
• Epidemiology of Parkinson’s disease

  2008cited by this paper
• Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

  2008cited by this paper
• Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.

  2008cited by this paper
• Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis

  2007cited by this paper
• Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects.

  2007cited by this paper
• Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter.

  2007cited by this paper
• Ubiquitin–proteasome system and Parkinson's disease

  2006cited by this paper
• Functional effects of neuromelanin and synthetic melanin in model systems

  2006cited by this paper
• Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain

  2005cited by this paper
• Regulatory mechanism of tyrosine hydroxylase activity.

  2005cited by this paper
• Alpha(2)-adrenergic receptor signalling in hypertension.

  2005cited by this paper
• α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells

  2005cited by this paper
• Regulation of N-terminus-deleted human tyrosine hydroxylase type 1 by end products of catecholamine biosynthetic pathway

  2005cited by this paper
• Effect of Psychiatric and Other Nonmotor Symptoms on Disability in Parkinson's Disease

  2004cited by this paper
• Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions.

  2004cited by this paper
• Cyclin-dependent Kinase 5 Phosphorylates Serine 31 of Tyrosine Hydroxylase and Regulates Its Stability*

  2004cited by this paper
• Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity.

  2003cited by this paper
• Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.

  2003cited by this paper
• Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form.

  2002cited by this paper
• The mutation of two amino acid residues in the N‐terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT‐20 cells

  2002cited by this paper
• Tyrosine hydroxylase deficiency: Clinical manifestations of catecholamine insufficiency in infancy

  2002cited by this paper
• Influence of neuromelanin on oxidative pathways within the human substantia nigra.

  2002cited by this paper
• Positive charge intrinsic to Arg37‐Arg38 is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1

  2000cited by this paper
• Tyrosine hydroxylase and Parkinson's disease

  1998cited by this paper
• Mitochondria in the etiology and pathogenesis of parkinson's disease

  1998cited by this paper
• Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System

  1997cited by this paper
• Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli.

  1997cited by this paper
• Dopamine synthesis, uptake, metabolism, and receptors: relevance to gene therapy of Parkinson's disease.

  1997cited by this paper
• Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases

  1997cited by this paper
• Tyrosinase mRNA is expressed in human substantia nigra.

  1997cited by this paper
• L-Dopa and dopamine-producing gene cassettes for gene therapy approaches to Parkinson's disease.

  1997cited by this paper
• Understanding Parkinson's disease.

  1997cited by this paper
• Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression

  1996cited by this paper
• Reconstruction of the Nigrostriatal Pathway by Simultaneous Intrastriatal and Intranigral Dopaminergic Transplants

  1996cited by this paper
• Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease.

  1995cited by this paper
• Crystal Structure of the Biphenyl-Cleaving Extradiol Dioxygenase from a PCB-Degrading Pseudomonad

  1995cited by this paper
• Genetic linkage studies in autosomal dominant parkinsonism: Evaluation of seven candidate genes

  1994cited by this paper
• Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia

  1994cited by this paper
• Biochemistry of Parkinson's disease with special reference to the dopaminergic systems

  1994cited by this paper
• Increased heterogeneity of tyrosine hydroxylase in humans.

  1993cited by this paper
• Limited proteolysis of rat brain tyrosine hydroxylase defines an N-terminal region required for regulation of cofactor binding and directing substrate specificity.

  1991cited by this paper
• Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions.

  1991cited by this paper
• Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing.

  1991cited by this paper
• A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

  1987cited by this paper
• TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.

  1964cited by this paper

• Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection

  2026cites this paper
• Tracking neurological diseases: advances in fluorescent probes design and application

  2026cites this paper
• In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders

  2025cites this paper
• Methylomic Signature and Epigenetic Damage Modulation of Bronte Pistachio (Pistacia vera L.) Hydrophilic Extract in Differentiated CaCo-2 Cells

  2025cites this paper
• Pediatric Genetic Dystonias: Current Diagnostic Approaches and Treatment Options

  2025cites this paper
• Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model

  2024cites this paper
• Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson’s disease

  2024cites this paper
• Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

  2024cites this paper
• Genome-Wide Analysis of Kidney Renal Cell Carcinoma: Exploring Differentially Expressed Genes for Diagnostic and Therapeutic Targets

  2023cites this paper
• Neonatal and infantile hypotonia.

  2023cites this paper
• Drug Interactions with Catecholamines and Metabolites. Evidence of Oxidative Stress and Inflammation On Pathways

  2022cites this paper
• Newborn Genetic Screening Revealed Increased Levels of Biochemical Indicators in Carriers of Heterozygous Variants

  2022cites this paper
• From the tyrosine hydroxylase hypothesis of Parkinson’s disease to modern strategies: a short historical overview

  2022cites this paper
• Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro.

  2022cites this paper
• Dopamine in Parkinson's disease.

  2021cites this paper
• Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm

  2021cites this paper
• Genetic Spectrum Identified by Exome Sequencing in a Chinese Pediatric Cerebral Palsy Cohort.

  2021cites this paper
• Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans.

  2020cites this paper
• Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine.

  2020cites this paper
• New insights into the lacrimal pump.

  2020cites this paper
• Microbiota Alters Urinary Bladder Weight and Gene Expression

  2020cites this paper
• Enzymes Processing Neurotransmitters

  2019cites this paper
• Introductory Chapter: “Feel Good” Chemical Dopamine - Role in Health and Disease

  2018cites this paper
• A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

  2018cites this paper
• Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease

  2016cites this paper
• The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

  2016cites this paper
• Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.

  2015cites this paper
• The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

  2015cites this paper
• Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates

  2015cites this paper
• Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions.

  2014cites this paper
• affeine neuroprotective effects on 6-OHDA-lesioned rats are ediated by several factors , including pro-inflammatory cytokines nd histone deacetylase inhibitions oão

  2014cites this paper
• Prepuberal intranasal dopamine treatment in an animal model of ADHD ameliorates deficient spatial attention, working memory, amino acid transmitters and synaptic markers in prefrontal cortex, ventral and dorsal striatum

  2014cites this paper
• EFEITO DA SECÇÃO DO NERVO ISQUIÁTICO SOBRE PARÂMETROS ULTRAESTRUTURAL, HISTOQUÍMICO, IMUNOISTOQUÍMICO E DE CAPTAÇÃO DE ANÁLOGOS DA GLICOSE EM GÂNGLIO DA RAIZ DORSAL DE RÃS Lithobates catesbianus

  2013cites this paper
• Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum

  2012cites this paper
• Optimization of tyrosine hydroxylase antibody for Optimization of tyrosine hydroxylase antibody for immunohistochemistry fluorescence detection in zebrafish (Danio immunohistochemistry fluorescence detection in zebrafish (

  year unknowncites this paper