One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge

Highlights • Creation of influenza H7-VLPs containing HAs from A/Shanghai/1/13 or A/Anhui/1/13.• Single low-dose vaccination is 100% protective against stringent SH1 challenge.• Single immunisation induces HI titres of up to 1:40.• Induction of broadly sero-reactive and HI-active antibodies.• Baculovirus impurities might beneficially contribute to protective efficacy.

• Publication year

  2014

• Venue

  Vaccine

• Publication date

  2014-01-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.vaccine.2013.11.036PMID 24262313PMCID 3906608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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