Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Respiratory Physiology & Neurobiology

• Publication date

  2012-07-31

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.resp.2012.05.016PMID 22627105
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study.

  2011cited by this paper
• Effects of phosphodiesterase inhibitors on the inflammatory response of endothelial cells stimulated by myeloperoxidase-modified low-density lipoprotein or tumor necrosis factor alpha.

  2010cited by this paper
• New insights in the pathogenesis of high-altitude pulmonary edema.

  2010cited by this paper
• Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

  2009cited by this paper
• Role of Oxidative Stress and NFkB in Hypoxia-Induced Pulmonary Edema

  2008cited by this paper
• Both Tadalafil and Dexamethasone May Reduce the Incidence of High-Altitude Pulmonary Edema

  2006cited by this paper
• High altitude-induced pulmonary oedema.

  2006cited by this paper
• Hypoxia causes permeability oedema in the constant-pressure perfused rat lung

  2006cited by this paper
• Physiological aspects of high-altitude pulmonary edema.

  2005cited by this paper
• Identification of individuals susceptible to high-altitude pulmonary oedema at low altitude

  2005cited by this paper
• Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.

  2005cited by this paper
• Effect of nifedipine on C-reactive protein levels in the coronary sinus and on coronary blood flow in response to acetylcholine in patients with stable angina pectoris having percutaneous coronary intervention.

  2005cited by this paper
• Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema.

  2005cited by this paper
• Sildenafil offers protection against NSAID‐induced gastric injury

  2005cited by this paper
• High Altitude Cerebral Edema

  2004cited by this paper
• Antioxidant effect of beta-carotene on hypoxia induced oxidative stress in male albino rats.

  2002cited by this paper
• Oxidative stress, transcription factors and chromatin remodelling in lung inflammation.

  2002cited by this paper
• Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor.

  2002cited by this paper
• The IKK/NF-kappa B pathway.

  2002cited by this paper
• Effects of a dual inhibitor of tumor necrosis factor-&agr; and interleukin-1 on lipopolysaccharide-induced lung injury in rats: Involvement of the p38 mitogen-activated protein kinase pathway

  2001cited by this paper
• Leukocyte-endothelial interactions in environmental hypoxia.

  2001cited by this paper
• High-Altitude Pulmonary Edema Is Initially Caused by an Increase in Capillary Pressure

  2001cited by this paper
• NF-kappaB activation.

  2000cited by this paper
• NF-κB activation

  2000cited by this paper
• Exaggerated pulmonary hypertension is not sufficient to trigger high-altitude pulmonary oedema in humans.

  2000cited by this paper
• Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.

  1999cited by this paper
• Glutathione and its role in cellular functions.

  1999cited by this paper
• Pulmonary hypertension in high-altitude chronic hypoxia: response to nifedipine.

  1998cited by this paper
• Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema.

  1998cited by this paper
• High altitude pulmonary edema.

  1997cited by this paper
• Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan.

  1996cited by this paper
• Free radicals : a practical approach

  1996cited by this paper
• NF-kappa B: ten years after.

  1996cited by this paper
• NF-κB: Ten Years After

  1996cited by this paper
• Evidence against an increase in capillary permeability in subjects exposed to high altitude.

  1996cited by this paper
• Cytokine expression in chronic inflammatory disease.

  1995cited by this paper
• Nifedipine does not prevent acute mountain sickness.

  1994cited by this paper
• Endotoxin priming followed by high altitude causes pulmonary edema in rats.

  1993cited by this paper
• Effect of antioxidants on hypoxia/reoxygenation-induced injury in isolated perfused rat liver.

  1992cited by this paper
• Prevention and Treatment of High Altitude Pulmonary Edema by a Calcium Channel Blocker

  1992cited by this paper
• Prevention of high-altitude pulmonary edema by nifedipine.

  1991cited by this paper
• Prevalence of acute mountain sickness in the Swiss Alps.

  1990cited by this paper
• Organometal-induced increases in oxygen reactive species: the potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage.

  1990cited by this paper
• Nifedipine for high altitude pulmonary edema: Oelz O, Ritter M, Jenni R, et al Lancet 1,241–1,244 Nov 1989

  1990cited by this paper
• Comparison of nifedipine, propranolol and isosorbide dinitrate on angiographic progression and regression of coronary arterial narrowings in angina pectoris.

  1989cited by this paper
• Nifedipine for high altitude pulmonary oedema.

  1989cited by this paper
• Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of µ opioid receptors in mice

  1988cited by this paper
• The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema.

  1988cited by this paper
• Hypoxia-induced increases in pulmonary transvascular protein escape in rats. Modulation by glucocorticoids.

  1988cited by this paper
• Clinical features of patients with high-altitude pulmonary edema in Japan.

  1987cited by this paper
• Glutathione.

  1983cited by this paper
• Biology of disease: free radicals and tissue injury.

  1982cited by this paper
• Rales, peripheral edema, retinal hemorrhage and acute mountain sickness.

  1979cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Effect of Increased Vascular Pressure on Lung Fluid Balance in Unanesthetized Sheep

  1975cited by this paper
• A new colorimetric method for the determination of glutathione in erythrocytes.

  1974cited by this paper
• Physiologic Studies of Pulmonary Edema at High Altitude

  1964cited by this paper
• Acute pulmonary edema of high altitude.

  1960cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Understanding the mechanistic and therapeutic perspectives on cytokines and chemokines in acute high-altitude illness syndromes

  2025cites this paper
• Recent updates on sickness during Acute High-altitude hypoxic exposure and its management

  2025cites this paper
• RETRACTED: Fischer’s ratio and DNA damage in hypoxemia-induced brain injury in rat model: prophylactic role of quercetin and mexamine supplementation

  2025cites this paper
• Hypobaric hypoxia promotes the production of IL-10 of lung NKT cells in HAPE rats to fight inflammation

  2025cites this paper
• Effects of different hypoxia exposure on myeloid-derived suppressor cells in mice.

  2024cites this paper
• The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology

  2024cites this paper
• Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation

  2024cites this paper
• Effect fraction of Bletilla striata (Thunb.) Reichb.f. alleviates LPS-induced acute lung injury by inhibiting p47phox/NOX2 and promoting the Nrf2/HO-1 signaling pathway.

  2023cites this paper
• High Altitude Pulmonary Edema: the intercellular network hypothesis.

  2023cites this paper
• Mechanism of SMND-309 against lung injury induced by chronic intermittent hypoxia.

  2022cites this paper
• Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling.

  2022cites this paper
• Anti-hypoxia effects of ginseng (Panax Ginseng C A Meyer) oligopeptides in mice

  2022cites this paper
• Estrogen-related Receptor α (ERRα) Functions in The Hypoxic Injury of Microglial Cells

  2022cites this paper
• The Targeting of Nuclear Factor Kappa B by Drugs Adopted for the Prevention and Treatment of Preeclampsia

  2022cites this paper
• Immunomodulatory properties of antihypertensive drugs and digitalis glycosides

  2022cites this paper
• Blocking TNF signaling may save lives in COVID-19 infection

  2022cites this paper
• Anti-hypoxia effects of walnut oligopeptides (Juglans regia L.) in mice.

  2021cites this paper
• Quercetin: a savior of alveolar barrier integrity under hypoxic microenvironment

  2021cites this paper
• Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2

  2021cites this paper
• The anti-hypoxic effects of oat (Avena sativa L.) oligopeptides in mice.

  2021cites this paper
• Hypoxia-mediated alterations in pulmonary surfactant protein expressions: Beneficial effects of quercetin prophylaxis.

  2021cites this paper
• Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease

  2021cites this paper
• Effects of Environmental and Pathological Hypoxia on Male Fertility

  2021cites this paper
• FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation

  2021cites this paper
• Epigenetic Regulation of Endothelial Dysfunction and Inflammation in Pulmonary Arterial Hypertension

  2021cites this paper
• FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation

  2021cites this paper
• FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation

  2021cites this paper
• Nicardipine Inhibits Priming of the NLRP3 Inflammasome via Suppressing LPS-Induced TLR4 Expression

  2020cites this paper
• Research advances in pathogenesis and prophylactic measures of acute high altitude illness.

  2018cites this paper
• Pulmonary surfactant-associated proteins and inflammatory factors in obstructive sleep apnea

  2018cites this paper
• ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

  2017cites this paper
• Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study.

  2017cites this paper
• The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function

  2016cites this paper
• Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome.

  2016cites this paper
• Attenuation of NFkB Activation Augments Alveolar Transport Proteins Expression and Activity under Hypoxia

  2015cites this paper
• [Role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia].

  2015cites this paper
• The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.

  2015cites this paper
• Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target.

  2015cites this paper
• High-Altitude Pulmonary Edema (HAPE)

  2014cites this paper
• Loss of calreticulin function decreases NFκB activity by stabilizing IκB protein.

  2014cites this paper
• Differential Modulation of S1PR(1–5) and Specific Activities of SphK and nSMase in Pulmonary and Cerebral Tissues of Rats Exposed to Hypobaric Hypoxia

  2014cites this paper
• Can High Altitude Influence Cytokines and Sleep?

  2013cites this paper
• The role of hypoxia in pulmonary vascular diseases: a perspective.

  2013cites this paper