Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular human reproduction

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/MOLEHR/GAH249PMID 16390854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology

  2006cited by this paper
• Endometriotic cells are resistant to interferon-gamma-induced cell growth inhibition and apoptosis: a possible mechanism involved in the pathogenesis of endometriosis.

  2005influential reference
• Medical management of endometriosis: a systematic review.

  2004cited by this paper
• An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis.

  2004cited by this paper
• Antiangiogenesis therapy for endometriosis.

  2004cited by this paper
• New medical treatments for endometriosis.

  2004influential reference
• Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells

  2004cited by this paper
• Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis.

  2004influential reference
• Endometriosis and infertility.

  2004cited by this paper
• Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells

  2003cited by this paper
• Endometriosis: Treatment Strategies

  2003influential reference
• Expression of collagen XVIII mRNA and protein in human umbilical vein and placenta.

  2003cited by this paper
• Conventional Medical Therapies for Endometriosis

  2002influential reference
• Selective Progesterone Receptor Modulators (SPRMs)

  2002cited by this paper
• New considerations for the pathogenesis of endometriosis

  2002cited by this paper
• Development of endometriosis-like lesions after transplantation of human endometrial fragments onto the chick embryo chorioallantoic membrane.

  2001cited by this paper
• Apoptosis in human endometrium: apoptotic detection methods and signaling

  2001cited by this paper
• Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC.

  2000cited by this paper
• Medical management of endometriosis and infertility.

  2000influential reference
• A comparative study of the acceptability and effect of goserelin and nafarelin on endometriosis

  2000cited by this paper
• Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells

  1999influential reference
• Adhesion of shed menstrual tissue in an in-vitro model using amnion and peritoneum: a light and electron microscopic study.

  1999cited by this paper
• Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis

  1998cited by this paper
• Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells

  1998influential reference
• Effects of triptorelin versus placebo on the symptoms of endometriosis.

  1998cited by this paper
• Bufadienolides from animal and plant sources.

  1998cited by this paper
• Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis.

  1998cited by this paper
• Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis.

  1998influential reference
• Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis.

  1998cited by this paper
• LAPAROSCOPIC SURGERY IN INFERTILE WOMEN WITH MINIMAL OR MILD ENDOMETRIOSIS

  1998cited by this paper
• Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts.

  1997cited by this paper
• Bcl-2 and Fas expression in eutopic and ectopic human endometrium during the menstrual cycle in relation to endometrial cell apoptosis.

  1997cited by this paper
• Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis.

  1997cited by this paper
• Follow-up report on a randomized controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal to moderate endometriosis.

  1997cited by this paper
• Cell Proliferation and apoptosis: Detection of apoptosis in human endometriotic tissues

  1996cited by this paper
• Detection of apoptosis in human endometriotic tissues.

  1996cited by this paper
• Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells.

  1995influential reference
• Calcium‐mediated cell injury and cell death

  1995cited by this paper
• Invasiveness of endometriotic cells in vitro.

  1995cited by this paper
• Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells.

  1994influential reference
• The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.

  1994cited by this paper
• Involvement of Na+, K+‐ATPase inhibition in K562 cell differentiation induced by bufalin

  1994influential reference
• Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells

  1994influential reference
• Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

  1993cited by this paper
• Pharmacological actions of "kyushin," a drug containing toad venom: cardiotonic and arrhythmogenic effects, and excitatory effect on respiration.

  1992cited by this paper
• Simultaneous Determination of Bufadienolides in the Traditional Chinese Medicine Preparation, Liu‐Shen‐Wan, by Liquid Chromatography *

  1992cited by this paper
• Bufalin and unidentified substance(s) in traditional Chinese medicine cross-react in commercial digoxin assay.

  1992cited by this paper
• HL‐60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

  1990cited by this paper
• Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

  1989cited by this paper
• Calcium-activated DNA fragmentation in rat liver nuclei.

  1989cited by this paper
• Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial.

  1988cited by this paper

• NAT10 drives endometriosis progression through acetylation and stabilization of TGFB1 mRNA.

  2024cites this paper
• Research Progress on Plant‐Derived Cardenolides (2010–2023)

  2024cites this paper
• Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase.

  2024cites this paper
• Dual inhibition of AKT and ERK1/2 Pathways Restores the Expression of Progesterone Receptor-B in Endometriotic Lesions through Epigenetic Mechanisms.

  2024cites this paper
• Hellebrigenin triggers death of promyelocytic leukemia cells by non-genotoxic ways.

  2023cites this paper
• Toad venom bufadienolides and bufotoxins: An updated review

  2023cites this paper
• Three new cardenolides from the fruits of Cascabela thevetia (L.) Lippold and their cytotoxic activities

  2022cites this paper
• Antiproliferative Bufadienolides from the Bulbs of Drimia altissima.

  2021cites this paper
• Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review

  2021influential citation
• hsa-miR-199a-3p Inhibits Motility, Invasiveness, and Contractility of Ovarian Endometriotic Stromal Cells

  2021cites this paper
• Chemokine expression profiles of ovarian endometriotic stromal cells in three-dimensional culture.

  2020cites this paper
• β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis

  2019cites this paper
• Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions.

  2019cites this paper
• Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology.

  2019cites this paper
• New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

  2019cites this paper
• Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis.

  2018cites this paper
• Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

  2018cites this paper
• Differential Effects of In Vitro Treatment with Cinobufotalin on Three Types of Ovarian Cancer Cells

  2018cites this paper
• Synthesis of breast cancer targeting conjugate of temporin‐SHa analog and its effect on pro‐ and anti‐apoptotic protein expression in MCF‐7 cells

  2018cites this paper
• Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway.

  2018cites this paper
• Digoxin reduces the mutagenic effects of Mitomycin C in human and rodent cell lines

  2017cites this paper
• Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis.

  2017cites this paper
• Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na+/K+‐ATPase inhibition

  2017cites this paper
• Cinobufotalin as a Novel Agent to Inhibit in Vitro Epithelial Ovarian Cancer Cell Proliferation, Migration and Invasion

  2016cites this paper
• Pharmacological treatment of endometriosis: review of current and new options for treatment

  2016cites this paper
• An overview of early drug development for endometriosis

  2016cites this paper
• Bufalin combined with hydroxycamptothecin affect in vitro cell growth and apoptosis of human Du 145 prostate cancer cells

  2016cites this paper
• studyfor the treatment of endometriosis: an in vitro B inhibitor BAY κ Application of the nuclear factor-

  2016cites this paper
• ID: 96: CINOBUFOTALIN AS A NOVEL AGENT TO INHIBIT IN-VITRO EPITHELIAL OVARIAN CANCER CELL PROLIFERATION, MIGRATION AND INVASION

  2016cites this paper
• Cinobufotalin impedes Sw.71 cytotrophoblast cell line function via cell cycle arrest and apoptotic signaling

  2016cites this paper
• miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells.

  2016cites this paper
• Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas.

  2014cites this paper
• Reevesioside A, a Cardenolide Glycoside, Induces Anticancer Activity against Human Hormone-Refractory Prostate Cancers through Suppression of c-myc Expression and Induction of G1 Arrest of the Cell Cycle

  2014cites this paper
• 21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions

  2014cites this paper
• Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells

  2014cites this paper
• Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

  2014cites this paper
• Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells.

  2014cites this paper
• Apoptosis in Endometriosis

  2014cites this paper
• Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line.

  2014cites this paper
• Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro

  2014cites this paper
• Pathogenesis of endometriosis: the role of initial infection and subsequent sterile inflammation (Review).

  2014cites this paper
• Artemisia leaf extract induces apoptosis in human endometriotic cells through regulation of the p38 and NFκB pathways.

  2013cites this paper
• Antiproliferative activity of Rhinella marina and Rhaebo guttatus venom extracts from Southern Amazon.

  2013cites this paper
• BUFADIENOLIDES AND THEIR MEDICINAL UTILITY: A REVIEW

  2013cites this paper
• The mechanism of action of bufalin in inhibition of lipid droplet accumulation in mouse macrophages.

  2013cites this paper
• Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis.

  2012cites this paper
• Pharmacologic therapies in endometriosis: a systematic review.

  2012cites this paper
• Investigation of the cytocidal potential of Rhinella jimi skin methanol extracts

  2012cites this paper
• Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells.

  2012cites this paper
• Bufalin enhances the antitumor effect of gemcitabine in pancreatic cancer.

  2012cites this paper
• Mechanism Underlying the Pathogenesis of Endometriosis Aberrant Expression of Apoptosis-Related Molecules in Endometriosis : A Possible

  2012cites this paper
• Bufadienolides and their antitumor activity.

  2011cites this paper
• Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells.

  2011cites this paper
• Apoptogenic activity and toxicity studies of a cytotoxic protein (BMP1) from the aqueous extract of common Indian toad (Bufo melanostictus Schneider) skin.

  2011cites this paper
• Pleiotropic effects of cardioactive glycosides.

  2011cites this paper
• Aberrant Expression of Apoptosis-Related Molecules in Endometriosis

  2011cites this paper
• Puerarin Suppresses Invasion and Vascularization of Endometriosis Tissue Stimulated by 17β-Estradiol

  2011cites this paper
• Apoptotic and anti-metastatic effects of the whole skin of Venenum bufonis in A549 human lung cancer cells

  2011cites this paper
• Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway.

  2011cites this paper
• Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion.

  2010cites this paper
• 蟾蜍灵对人非小细胞肺癌A549细胞增殖与凋亡的影响

  2010cites this paper
• Marinobufagenin causes endothelial cell monolayer hyperpermeability by altering apoptotic signaling.

  2009cites this paper
• Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells.

  2009influential citation
• Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.

  2009cites this paper
• Bufalin inhibits CYP3A4 activity in vitro and in vivo

  2009cites this paper
• Involvement of resistance to apoptosis in the pathogenesis of endometriosis.

  2009cites this paper
• Simultaneous determination and pharmacokinetics of five bufadienolides in rat plasma after oral administration of Chansu extract by SPE-HPLC method.

  2008cites this paper
• Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells.

  2008cites this paper
• Cardiac Glycosides as Novel Cancer Therapeutic Agents History of the Use of Cardiac Glycosides for Cancer

  2008cites this paper
• Cytotoxic activity of an octadecenoic acid extract from Euphorbia kansui (Euphorbiaceae) on human tumour cell strains

  2008cites this paper
• Cardiac glycosides as novel cancer therapeutic agents.

  2008cites this paper
• Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells.

  2008cites this paper
• Apoptotic signaling in bufalin‐ and cinobufagin‐treated androgen‐dependent and ‐independent human prostate cancer cells

  2008cites this paper
• Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells.

  2008cites this paper
• Examination of the Cellular Mechanisms by Which Marinobufagenin Inhibits Cytotrophoblast Function*

  2008cites this paper
• The cardiotonic steroid Marinobufagenin (MBG) induces Epithelial-Mesenchymal Transition (EMT) in LLC-PK1 cells

  2007cites this paper
• Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.

  2007cites this paper
• A crystalline compound (BM-ANF1) from the Indian toad (Bufo melanostictus, Schneider) skin extract, induced antiproliferation and apoptosis in leukemic and hepatoma cell line involving cell cycle proteins.

  2007cites this paper
• Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis.

  2007cites this paper
• and study 11-7085 for the treatment of endometriosis : an in vitro B inhibitor BAY κ Application of the nuclear factor

  2007influential citation
• Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

  2007influential citation
• Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines

  2007cites this paper
• Application of the nuclear factor-κB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study

  2007cites this paper
• Apoptosis and endometriosis.

  2007cites this paper
• Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study.

  2006cites this paper