Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of applied physiology

• Publication date

  2012-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/japplphysiol.01079.2012PMID 23042910PMCID PMC3544507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Carbon Monoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia

  2011cited by this paper
• Carbon monoxide as an endogenous vascular modulator.

  2011cited by this paper
• Early Treatment of Transient Focal Cerebral Ischemia with Bovine PEGylated Carboxy Hemoglobin Transfusion

  2010cited by this paper
• Decreased Damage From Transient Focal Cerebral Ischemia by Transfusion of Zero-Link Hemoglobin Polymers in Mouse

  2009influential reference
• Low Doses of Carbon Monoxide Protect Against Experimental Focal Brain Ischemia

  2009cited by this paper
• Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion.

  2009influential reference
• CO‐MP4, a polyethylene glycol‐conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

  2008influential reference
• A BRIEF COMMUNICATION

  2007cited by this paper
• Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities.

  2007cited by this paper
• Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse.

  2006cited by this paper
• Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca2+-Activated K+ Channels

  2005cited by this paper
• A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter.

  2003cited by this paper
• Regional cerebral blood flow in cats with cross-linked hemoglobin transfusion during focal cerebral ischemia.

  2002cited by this paper
• Vascular response to infusions of a nonextravasating hemoglobin polymer.

  2002cited by this paper
• Adipyl crosslinked bovine hemoglobins as new models of allosteric systems

  2000cited by this paper
• Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke.

  1999cited by this paper
• Gender-linked brain injury in experimental stroke.

  1998cited by this paper
• Entropy-driven intermediate steps of oxygenation may regulate the allosteric behavior of hemoglobin.

  1998cited by this paper
• Hypervolemic-hemodilution during cerebral ischemia in rats: effect of diaspirin cross-linked hemoglobin (DCLHb) on neurologic outcome and infarct volume.

  1997cited by this paper
• Effect of Oncotic Pressure of Diaspirin Cross-Linked Hemoglobin (DCLHb Trademark) on Brain Injury After Temporary Focal Cerebral Ischemia in Rats

  1996cited by this paper
• Focal Cerebral Ischemia in Rats: Effect of Hemodilution with α-α Cross-Linked Hemoglobin on Brain Injury and Edema

  1993cited by this paper
• Focal Cerebral Ischemia in Rats: Effect of Hypervolemic Hemodilution with Diaspirin Cross‐linked Hemoglobin Versus Albumin on Brain Injury and Edema

  1993cited by this paper
• Focal cerebral ischemia in rats: effect of hemodilution with alpha-alpha cross-linked hemoglobin on brain injury and edema.

  1993cited by this paper
• PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.

  1992cited by this paper
• The CBF Threshold and Dynamics for Focal Cerebral Infarction in Spontaneously Hypertensive Rats

  1992cited by this paper
• Comparison of Cerebrovascular Response to Hypoxic and Carbon Monoxide Hypoxia in Newborn and Adult Sheep

  1984cited by this paper

• Sex‐dependent role of 20‐HETE synthesis in outcome from ischemic stroke in rats

  2026cites this paper
• Biophysical and Biochemical Characterization of High Molecular Weight Co-Polymerized Human Hemoglobin and Albumin as a Potential Hemoglobin-Based Oxygen Carrier.

  2025cites this paper
• HEMERA 1 CarboxyHEMoglobin oxygEn delivery for Revascularization in Acute Stroke: A Prospective, Randomized Phase 1 Clinical Trial

  2024cites this paper
• Current and emerging drug treatment strategies to tackle sickle cell anemia

  2024cites this paper
• Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock

  2023cites this paper
• Neuroprotective effects of a hemoglobin-based oxygen carrier (stroma-free hemoglobin nanoparticle) on ischemia reperfusion injury.

  2023cites this paper
• Embolic occlusion of internal carotid artery in conscious rats: Immediate effects of cerebral ischemia

  2023influential citation
• Neurointerventional infusion of hemoglobin oxygen carrier prevents brain damage from acute cerebral ischemia in rats

  2023cites this paper
• Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH)

  2022cites this paper
• Therapeutic Induction of Collateral Flow

  2022cites this paper
• Promising Cerebral Blood Flow Enhancers in Acute Ischemic Stroke

  2022cites this paper
• Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague–Dawley rats

  2022cites this paper
• Carbon Monoxide–Saturated Polymerized Placenta Hemoglobin Optimizes Mitochondrial Function and Protects Heart Against Ischemia–Reperfusion Injury

  2021cites this paper
• Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

  2020cites this paper
• Stepping stones to the future of haemoglobin-based blood products: clinical, preclinical and innovative examples.

  2020cites this paper
• Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

  2020cites this paper
• Semisynthetic supra plasma expanders: a new class of therapeutics to improve microcircualtion in sickle cell anaemia

  2019cites this paper
• Effect of Polyethylene-glycolated Carboxyhemoglobin on Renal Microcirculation in a Rat Model of Hemorrhagic Shock.

  2019influential citation
• Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

  2018cites this paper
• Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

  2018cites this paper
• Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally.

  2018cites this paper
• Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications.

  2018cites this paper
• Oxidative pathways in the sickle cell and beyond.

  2017cites this paper
• Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion

  2017cites this paper
• Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

  2017cites this paper
• Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

  2017cites this paper
• Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers

  2017cites this paper
• The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso‐occlusive crises

  2017cites this paper
• Comparative Response of Brain to Chronic Hypoxia and Hyperoxia

  2017cites this paper
• Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats

  2017cites this paper
• SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update

  2017cites this paper
• SANGUINATE™ (PEGylated Carboxyhemoglobin Bovine) Improves Cerebral Blood Flow to Vulnerable Brain Regions at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

  2017cites this paper
• Polynitroxylated Pegylated Hemoglobin—A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation

  2017cites this paper
• Sickle Cell Disease, Severe Acidosis, and Inhalation Injury: Case Report of Neurologically Intact Survival After Cardiac Arrest From Smoke Inhalation

  2017cites this paper
• A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia

  2016cites this paper
• A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice

  2016cites this paper
• Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact.

  2016cites this paper
• PEGylated Bovine Carboxyhemoglobin (SANGUINATE™): Results of Clinical Safety Testing and Use in Patients.

  2016cites this paper
• Conformation of the Poly(ethylene Glycol) Chains in DiPEGylated Hemoglobin Specifically Probed by SANS: Correlation with PEG Length and in Vivo Efficiency.

  2015cites this paper
• Lost in translation

  2015cites this paper
• Hemoglobin-based oxygen carriers: An update on their continued potential for military application

  2014cites this paper
• PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial.

  2014cites this paper
• Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

  2014cites this paper
• Carbon monoxide: Anticoagulant or procoagulant?

  2014cites this paper
• Ischemic Rescue with Hemoglobin-Based Oxygen Carriers

  2013cites this paper