Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuroscience

• Publication date

  2011-08-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuroscience.2011.05.066PMID 21664436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cysteinyl leukotriene receptor expression pattern affects migration of breast cancer cells and survival of breast cancer patients

  2011cited by this paper
• CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes.

  2011cited by this paper
• Montelukast, a cysteinyl leukotriene receptor‐1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats

  2011cited by this paper
• Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia

  2010cited by this paper
• Cysteinyl Leukotrienes and Their Receptors: Molecular and Functional Characteristics

  2010cited by this paper
• Ligand-Induced Tyrosine Phosphorylation of Cysteinyl Leukotriene Receptor 1 Triggers Internalization and Signaling in Intestinal Epithelial Cells

  2010cited by this paper
• Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer.

  2010cited by this paper
• Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

  2010cited by this paper
• Microglial activation in stroke: Therapeutic targets

  2010cited by this paper
• GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4

  2009cited by this paper
• The bright side of the glial scar in CNS repair

  2009cited by this paper
• [Preparation and identification of polyclonal antibody against cysteinyl leukotriene receptor 2].

  2009cited by this paper
• Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.

  2009cited by this paper
• Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor

  2009cited by this paper
• P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells1

  2009cited by this paper
• Astrocytes: biology and pathology

  2009cited by this paper
• Cysteinyl leukotriene 2 receptor‐mediated vascular permeability via transendothelial vesicle transport

  2008cited by this paper
• Activation of CysLT receptors induces astrocyte proliferation and death after oxygen–glucose deprivation

  2008cited by this paper
• Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.

  2008cited by this paper
• A new penumbra: transitioning from injury into repair after stroke

  2008cited by this paper
• Spatio-temporal expression of cysteinyl leukotriene receptor-2 mRNA in rat brain after focal cerebral ischemia.

  2007cited by this paper
• CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.

  2007cited by this paper
• Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends

  2007cited by this paper
• IFN-γ Induces Cysteinyl Leukotriene Receptor 2 Expression and Enhances the Responsiveness of Human Endothelial Cells to Cysteinyl Leukotrienes1

  2007cited by this paper
• The inflammatory response in stroke.

  2007cited by this paper
• An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation.

  2007cited by this paper
• Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression.

  2006cited by this paper
• Inflammation in ischemic brain injury: timing is important.

  2006cited by this paper
• Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice

  2006cited by this paper
• Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.

  2006cited by this paper
• Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death.

  2006cited by this paper
• Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats.

  2006cited by this paper
• P2Y1 and Cysteinyl Leukotriene Receptors Mediate Purine and Cysteinyl Leukotriene Co-Release in Primary Cultures of Rat Microglia

  2005cited by this paper
• Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice.

  2005cited by this paper
• Cysteinyl Leukotrienes and Their Receptors: Cellular Distribution and Function in Immune and Inflammatory Responses1

  2004cited by this paper
• Directed Vascular Expression of Human Cysteinyl Leukotriene 2 Receptor Modulates Endothelial Permeability and Systemic Blood Pressure

  2004cited by this paper
• Targeted Gene Disruption Reveals the Role of the Cysteinyl Leukotriene 2 Receptor in Increased Vascular Permeability and in Bleomycin-induced Pulmonary Fibrosis in Mice*

  2004cited by this paper
• Cysteinyl‐leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys‐LT1 receptors and mitogen‐activated protein kinase pathway

  2004cited by this paper
• Ischemic tolerance and endogenous neuroprotection.

  2003cited by this paper
• Neuroprotective Effect of Urinary Trypsin Inhibitor against Focal Cerebral Ischemia–Reperfusion Injury in Rats

  2003cited by this paper
• Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice.

  2003cited by this paper
• International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

  2003cited by this paper
• Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats.

  2002cited by this paper
• Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

  2001cited by this paper
• Characterization of the Human Cysteinyl Leukotriene 2 Receptor*

  2000cited by this paper
• Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

  1986cited by this paper

• New insights on pharmacological potential of montelukast: a comprehensive review

  2025cites this paper
• Unraveling cysteinyl leukotrienes and their receptors in inflammation through the brain-gut-lung axis

  2025cites this paper
• A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury.

  2024cites this paper
• Leukotriene signaling in neurodegeneration: implications for treatment strategies

  2024cites this paper
• Neuromodulatory Effects of Leukotriene receptor antagonists: A comprehensive review.

  2024cites this paper
• Leukotriene Signaling as a Target in α-Synucleinopathies

  2022cites this paper
• Anti-leukotriene drugs in the therapy of inflammatory diseases

  2022cites this paper
• Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing

  2022cites this paper
• Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats

  2022cites this paper
• Potential Effects of Leukotriene Receptor Antagonist Montelukast in Treatment of Neuroinflammation in Parkinson’s Disease

  2021cites this paper
• EFFECTS AND UNDERLYING MECHANISM OF 5-LIPOXYGENASE INHIBITOR (ZILEUTON) ON MICE DEPRESSIVE-LIKE BEHAVIOR

  2020cites this paper
• Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation.

  2020cites this paper
• MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization

  2020cites this paper
• Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway.

  2019cites this paper
• The leukotriene signaling pathway: a druggable target in Alzheimer's disease.

  2019cites this paper
• A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease.

  2019cites this paper
• The Role of Eicosanoids in Alzheimer’s Disease

  2019cites this paper
• Modulation of neuroinflammation by cysteinyl leukotriene 1 and 2 receptors: implications for cerebral ischemia and neurodegenerative diseases.

  2019cites this paper
• Expression of cysteinyl leukotriene receptor in brain tissues of rats with Streptococcus pneumoniae meningitis.

  2019cites this paper
• 5-LIPOXYGENASE INHIBITOR (ZILEUTON) PRODUCES ANTI-DEPRESSION EFFECT IN STRESS INDUCE CRS MICE MODEL

  2019cites this paper
• The Role of Montelukast in Traumatic Brain Injury and Brain Ischemia

  2019cites this paper
• GPR17 mediates ischemia-like neuronal injury via microglial activation

  2018cites this paper
• Neuroprotective effect of HAMI 3379 , a CysLT 2 R receptor antagonist , on chronic brain injury after focal cerebral ischemia in rats

  2017cites this paper
• The biphasic function of microglia in ischemic stroke

  2017cites this paper
• The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field

  2017cites this paper
• Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases

  2017influential citation
• Polyunsaturated fatty acids and endocannabinoids in health and disease

  2017cites this paper
• Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders

  2016cites this paper
• HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats.

  2015cites this paper
• The central role of aquaporins in the pathophysiology of ischemic stroke

  2015cites this paper
• CysLT2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro.

  2015cites this paper
• Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

  2014cites this paper
• Inflammation in ischemic stroke: mechanisms, consequences and possible drug targets.

  2014cites this paper
• Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⁺ T cells across an in vitro blood-brain barrier model.

  2014cites this paper
• The role of astrocytes in mediating exogenous cell‐based restorative therapy for stroke

  2014cites this paper
• HAMI 3379, a CysLT2 Receptor Antagonist, Attenuates Ischemia-Like Neuronal Injury by Inhibiting Microglial Activation

  2013cites this paper
• Cerebral Ischemia Is Exacerbated by Extracellular Nicotinamide Phosphoribosyltransferase via a Non-Enzymatic Mechanism

  2013cites this paper
• Cysteinyl leukotriene receptor 2 activation mediates post-myocardial ischemia/reperfusion injury inflammatory processes

  2013cites this paper
• Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro

  2013cites this paper
• Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors.

  2013cites this paper
• Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice

  2012influential citation
• Disruption of the alox5ap gene ameliorates focal ischemic stroke: possible consequence of impaired leukotriene biosynthesis

  2012cites this paper
• The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats.

  2012cites this paper
• Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats.

  2012cites this paper
• Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1

  2012cites this paper