The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses

DNA damage induces Chk2/Mnk-dependent mitotic and developmental blocks in early Drosophila embryos. The Mnk-FHA domain and its phosphopeptide-binding ability play essential dual functions in mediating the embryonic DNA damage response: activating Mnk upon DNA damage and recruiting Mnk to multiple cellular structures independently of DNA damage.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E14-07-1238PMID 25808488PMCID 4436828
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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