Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-05-0099PMID 16546979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.

  2003cited by this paper
• Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation*

  2003cited by this paper
• VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide.

  2003cited by this paper
• Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

  2002cited by this paper
• Pten signaling in gliomas.

  2002cited by this paper
• The Protein Tyrosine Phosphatase TCPTP Suppresses the Tumorigenicity of Glioblastoma Cells Expressing a Mutant Epidermal Growth Factor Receptor*

  2001cited by this paper
• The discovery of potent cRaf1 kinase inhibitors.

  2000influential reference
• Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

  2000cited by this paper
• Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

  1999cited by this paper
• PTEN mutations in gliomas and glioneuronal tumors

  1998cited by this paper
• Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy.

  1998cited by this paper
• Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

  1998cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  1998cited by this paper
• PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

  1997cited by this paper
• Patterns of epidermal growth factor receptor amplification in malignant gliomas.

  1996cited by this paper
• Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

  1991cited by this paper
• Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.

  1984cited by this paper
• Analysis of combined drug effects: a new look at a very old problem

  1983influential reference
• A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems.

  1977cited by this paper

• Crosstalk between protein kinases AKT and ERK1/2 in human lung tumor-derived cell models

  2023cites this paper
• Systematic Review of Molecular Targeted Therapies for Adult-Type Diffuse Glioma: An Analysis of Clinical and Laboratory Studies

  2023cites this paper
• The discovery of indolone GW5074 during a comprehensive search for non-polyamine-based polyamine transport inhibitors.

  2021cites this paper
• Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer.

  2019cites this paper
• Aspirin Affects Tumor Angiogenesis and Sensitizes Human Glioblastoma Endothelial Cells to Temozolomide, Bevacizumab, and Sunitinib, Impairing Vascular Endothelial Growth Factor-Related Signaling.

  2018cites this paper
• The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme

  2017cites this paper
• Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells

  2017cites this paper
• Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer

  2016cites this paper
• Inhibition of integrin-linked kinase expression by emodin through crosstalk of AMPKα and ERK1/2 signaling and reciprocal interplay of Sp1 and c-Jun.

  2015cites this paper
• A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

  2015cites this paper
• Correction: A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

  2015cites this paper
• THE TWEAK-FN14 LIGAND RECEPTOR AXIS PROMOTES GLIOBLASTOMA CELL INVASION AND SURVIVAL VIA ACTIVATION OF MULTIPLE GEF-RHO GTPASE SIGNALING SYSTEMS

  2013cites this paper
• Targeting Ras-RAF-ERK and its Interactive Pathways as a Novel Therapy for Malignant Gliomas

  2013cites this paper
• Antisense Oligonucleotides Therapy in the Treatment of Cerebral Gliomas: A Review

  2013cites this paper
• Papel de B-RAF en la progresión del cáncer de tiroides: cooperación con TGFβ en la transición epitelio-mesénquima

  2013cites this paper
• Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

  2013cites this paper
• Gliomas Biology: Angiogenesis and Invasion

  2013cites this paper
• Evaluation of Tyrosine Kinase Inhibitor Combinations for Glioblastoma Therapy

  2012cites this paper
• Improving treatment outcomes in models of glioblastoma cancer

  2011influential citation
• Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival

  2011cites this paper
• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

  2011cites this paper
• Integrin-linked kinase, phosphorylated AKT and the prognosis of malignant pleural mesothelioma.

  2011cites this paper
• Immunomodulation by Shark Cartilage Extracts

  2011cites this paper
• The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.

  2010cites this paper
• Integrin Linked Kinase as a therapeutic target for treating breast cancer : the value of using multiple endpoints to assess therapeutic effects of targeted drugs and drug combinations

  2010cites this paper
• Prognostic significance of integrin‐linked kinase1 overexpression in astrocytoma

  2010cites this paper
• The Role of Integrin-Linked Kinase in Cancer Development and Progression

  2010cites this paper
• Expression of EGFR,Grb2,p-mTOR and VEGF in human colorectal cancer tissues: Expression of EGFR,Grb2,p-mTOR and VEGF in human colorectal cancer tissues

  2010cites this paper
• Systems Biology of the MAPK1,2 Network

  2010cites this paper
• Studies on signal transduction mechanisms in rhabdomyosarcoma.

  2010cites this paper
• Anti-Angiogenic Therapy Induces Integrin-Linked Kinase 1 Up-Regulation in a Mouse Model of Glioblastoma

  2010cites this paper
• Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas.

  2010cites this paper
• The mitotic functions of integrin-linked kinase

  2009cites this paper
• siRNA-Mediated Integrin-Linked Kinase Suppression: Nonspecific Effects of siRNA/Cationic Liposome Complexes Trigger Changes in the Expression of Phosphorylated-AKT and mTOR Independently of ILK Silencing

  2009influential citation
• Targeting the EGFR and the PKB pathway in cancer.

  2009cites this paper
• QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

  2009cites this paper
• Chloroquine Inhibits Colon Cancer Cell Growth In Vitro and Tumor Growth In Vivo via Induction of Apoptosis

  2009cites this paper
• Combined effect of protein kinase B inhibitor or extracellular signal-regulated kinase inhibitor against farnesyltransferase inhibition-induced apoptosis in SiHa cells

  2009cites this paper
• RAF expression in human astrocytic tumors.

  2009cites this paper
• Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo

  2009cites this paper
• Pharmacogenomic and mechanistic studies on dietary factors in chemoprevention of cancer

  2008cites this paper
• αvβ3 and αvβ5 integrins control glioma cell response to ionising radiation through ILK and RhoB

  2008cites this paper
• Integrin-linked kinase – essential roles in physiology and cancer biology

  2008influential citation
• Integrin-linked kinase: a potential therapeutic target for the treatment of glioma.

  2008cites this paper
• Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic β-Cell Apoptosis*

  2008cites this paper
• Integrin-linked kinase: dispensable for radiation survival of three-dimensionally cultured fibroblasts.

  2008cites this paper
• ANTI-ADHESION evolves to a promising therapeutic concept in oncology.

  2008cites this paper
• Designer Therapies for Glioblastoma Multiforme

  2008cites this paper
• Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

  2008cites this paper
• Putative allosteric MEK1 and MEK2 inhibitors

  2008cites this paper
• Combination therapy for malignant glioma based on PTEN status

  2008cites this paper
• Selective Raf inhibition in cancer therapy

  2007cites this paper
• Molecularly targeted therapies for malignant gliomas: advances and challenges

  2007cites this paper
• Malignant glioma drug discovery – targeting protein kinases

  2007cites this paper
• Implication des voies de signalisation de l'adhérence cellulaire dans le contrôle de l'hypoxie tumorale des glioblastomes

  2007cites this paper
• Targeted Agents: The Rules of Combination

  2007cites this paper
• Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy.

  2007cites this paper
• The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion

  2007cites this paper
• In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway– and microtubule-targeting inhibitors

  2007cites this paper
• A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII

  2007cites this paper
• Signalling via integrins: implications for cell survival and anticancer strategies.

  2007cites this paper
• An Essential Role for the Integrin-Linked Kinase–Glycogen Synthase Kinase-3β Pathway during Dendrite Initiation and Growth

  2006cites this paper