Age-Related Differences in Biomarkers of Acute Inflammation During Hospitalization for Sepsis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Shock

• Publication date

  2014-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/SHK.0000000000000182PMID 24978893PMCID PMC4101036
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aged Mice Are Unable To Mount an Effective Myeloid Response to Sepsis

  2014cited by this paper
• Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults.

  2014cited by this paper
• Severe sepsis and septic shock.

  2013cited by this paper
• Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis.

  2013cited by this paper
• Severe sepsis and septic shock

  2013cited by this paper
• Genomic responses in mouse models poorly mimic human inflammatory diseases

  2013cited by this paper
• Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?

  2013cited by this paper
• Inflection points in sepsis biology: from local defense to systemic organ injury.

  2012cited by this paper
• Nationwide trends of severe sepsis in the 21st century (2000-2007).

  2011cited by this paper
• Dysregulated inflammation as a risk factor for pneumonia in the elderly.

  2011cited by this paper
• Interleukin‐6, C‐Reactive Protein, and Tumor Necrosis Factor‐Alpha as Predictors of Mortality in Frail, Community‐Living Elderly Individuals

  2011cited by this paper
• Higher Serum sTNFR1 Level Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease

  2011cited by this paper
• Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness.

  2011cited by this paper
• Toward an integrated research agenda for critical illness in aging.

  2010cited by this paper
• The Effects of Age on Inflammatory and Coagulation-Fibrinolysis Response in Patients Hospitalized for Pneumonia

  2010cited by this paper
• Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations.

  2009cited by this paper
• Markers of Inflammation and Risk of Coronary Heart Disease

  2009cited by this paper
• Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992.

  2009cited by this paper
• Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease.

  2009cited by this paper
• A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis

  2009influential reference
• Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.

  2008cited by this paper
• Evaluation and management of geriatric infections in the emergency department.

  2008cited by this paper
• Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.

  2007cited by this paper
• Inflammatory networks in ageing, age-related diseases and longevity.

  2007cited by this paper
• Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis

  2007cited by this paper
• Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*

  2007cited by this paper
• The effect of age on the development and outcome of adult sepsis*

  2006cited by this paper
• PLASMA CYTOKINE MEASUREMENTS AUGMENT PROGNOSTIC SCORES AS INDICATORS OF OUTCOME IN PATIENTS WITH SEVERE SEPSIS

  2005cited by this paper
• Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.

  2005cited by this paper
• The immunopathogenesis of sepsis in elderly patients.

  2005cited by this paper
• Effects of Age on Mortality and Antibiotic Efficacy in Cecal Ligation and Puncture

  2003cited by this paper
• The pathophysiology and treatment of sepsis.

  2003cited by this paper
• Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis.

  2003cited by this paper
• Six at Six: Interleukin-6 Measured 6 H After the Initiation of Sepsis Predicts Mortality Over 3 Days

  2002cited by this paper
• The Effect of Aging on Circulating Levels of Proinflammatory Cytokines During Septic Shock

  2001cited by this paper
• Ageing Is Associated with a Prolonged Fever Response in Human Endotoxemia

  2001cited by this paper
• Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

  2001influential reference
• Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections.

  1999cited by this paper
• Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group.

  1998cited by this paper
• Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock

  1998cited by this paper
• Balance of inflammatory cytokines related to severity and mortality of murine sepsis

  1996cited by this paper
• Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly.

  1996cited by this paper
• INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group.

  1996cited by this paper
• Lipopolysaccharide-induced lethality and cytokine production in aged mice

  1996cited by this paper
• American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

  1992cited by this paper
• Cytokine serum level during severe sepsis in human IL-6 as a marker of severity.

  1992cited by this paper

• Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility.

  2026cites this paper
• Therapeutic Potential of Plant-Derived Small Extracellular Vesicles in Sepsis: A Network Meta-analysis.

  2025cites this paper
• Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda

  2025cites this paper
• Systemic immune response of burns from the acute to chronic phase

  2024cites this paper
• Host Response in Critically Ill Patients Aged 65 Years or Older: A Prospective Study

  2024cites this paper
• Differential expression of plasma cytokines in sepsis patients and their clinical implications

  2024cites this paper
• Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups

  2024cites this paper
• Neutrophil-to-Lymphocyte Ratio and Procalcitonin in Sepsis Patients: Do They Have Any Prognostic Significance?

  2024cites this paper
• The Impact of Immune System Aging on Infectious Diseases

  2024cites this paper
• Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota.

  2023cites this paper
• Early intestinal microbiota changes in aged and adult mice with sepsis

  2022cites this paper
• Association between age and the host response in critically ill patients with sepsis

  2022cites this paper
• Novel plasma protein biomarkers from critically ill sepsis patients

  2022cites this paper
• Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding.

  2022cites this paper
• Goodnight, sleep tight, don't let the microbes bite: a review of sleep and its effects on sepsis and inflammation.

  2022cites this paper
• Sepsis-Induced Myopathy and Gut Microbiome Dysbiosis: Mechanistic Links and Therapeutic Targets

  2021cites this paper
• Older adults demonstrate biomarker evidence of the persistent inflammation, immunosuppression and catabolism syndrome (PICS) after sepsis.

  2021influential citation
• Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis

  2021cites this paper
• Age Is Associated With the Efficacy of Anticoagulant Therapies Against Sepsis-Induced Disseminated Intravascular Coagulation

  2021cites this paper
• Biomarker screening and validation for the differentiation of bloodstream infection from adult-onset Still's disease: A prospective cohort study.

  2021cites this paper
• Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

  2019cites this paper
• University of Birmingham Inflammation and neutrophil immunosenescence in health and disease

  2018cites this paper
• Energy Expenditure After Liver Resection: Validation of a Mobile Device for Estimating Resting Energy Expenditure and an Investigation of Energy Expenditure Change After Liver Resection

  2017cites this paper
• Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly

  2017cites this paper
• A Novel Combination of Biomarkers to Herald the Onset of Sepsis Prior to the Manifestation of Symptoms

  2017cites this paper
• Could Biomarkers Direct Therapy for the Septic Patient?

  2016cites this paper
• Enhanced recovery after liver surgery

  2016cites this paper
• Urinary neutrophil gelatinase-associated lipocalin in critically ill surgical cancer patients

  2015cites this paper
• Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections

  2015cites this paper
• Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

  2015cites this paper
• Extracorporeal Treatments for Abdominal Sepsis

  2015cites this paper
• What's New in Shock, August 2014?

  2014cites this paper