General approach to the coupling of organoindium reagents with imines via copper catalysis.

[reaction: see text] A copper-catalyzed three-component coupling of organoindium reagents with imines and acid chlorides is described. This mild carbon-carbon bond forming reaction requires only one-third of an equivalent of indium reagent to proceed in high yield, with the sole byproduct being indium trichloride. The reaction demonstrates broad generality, with aryl-, heteroaryl-, vinyl-, and alkylindiums, as well as functionalized imines and acid chlorides, all providing alpha-substituted amides or N-protected amines in a single step.

• Publication year

  2006

• Venue

  Organic Letters

• Publication date

  2006-04-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/OL060277PPMID 16671764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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