The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: preclinical studies in ethanol-preferring and outbred Wistar rats.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Alcoholism: Clinical and Experimental Research

• Publication date

  1998-12-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1111/J.1530-0277.1998.TB05931.XPMID 9884166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide

  2005cited by this paper
• High-affinity benzodiazepine antagonists reduce responding maintained by ethanol presentation in ethanol-preferring rats.

  1998cited by this paper
• SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

  1997cited by this paper
• Combination of naltrexone and fluoxetine on rats' propensity to take alcoholic beverage.

  1997cited by this paper
• Endogenous opioid systems and alcohol addiction

  1997cited by this paper
• Dosing issues in the pharmacotherapy of alcoholism.

  1996cited by this paper
• Periodic naltrexone and propensity to take alcoholic beverage.

  1996cited by this paper
• Effect of naltrexone on alcohol "high" in alcoholics.

  1995cited by this paper
• Genetic factors in alcohol self-administration.

  1995cited by this paper
• Genetic factors in alcohol self-administration.

  1995cited by this paper
• Naltrexone and Brief Counseling to Reduce Heavy Drinking: Results of a Small Clinical Trial

  1994cited by this paper
• Behavioral effects of 6-methylene naltrexone (nalmefene) in rhesus monkeys.

  1994cited by this paper
• A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence.

  1994cited by this paper
• Naltrexone and Brief Counseling to Reduce Heavy Drinking

  1994cited by this paper
• Naltrexone in the treatment of alcohol dependence.

  1992cited by this paper
• Naltrexone and coping skills therapy for alcohol dependence. A controlled study.

  1992cited by this paper
• Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage.

  1991cited by this paper
• Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.

  1990cited by this paper
• Alcohol-Abuse and Alcoholism

  1990cited by this paper
• Duration of antagonistic effects of nalmefene and naloxone in opiate-induced sedation for emergency department procedures.

  1989cited by this paper
• Ethanol reinforcement in the alcohol nonpreferring rat: initiation using behavioral techniques without food restriction.

  1989cited by this paper
• Comparison of the duration of action of nalmefene and naloxone on the hypothalamic-pituitary axis of the rhesus monkey.

  1989cited by this paper
• Dependence studies on new compounds in the rhesus monkey, rat and mouse (1989).

  1989cited by this paper
• Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys.

  1989cited by this paper
• Duration of occupancy of opiate receptors by naltrexone.

  1988cited by this paper
• Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.

  1987cited by this paper
• Nalmefene: Safety and Kinetics After Single and Multiple Oral Doses of a New Opioid Antagonist

  1987cited by this paper
• Prolonged blockade of opioid effect with oral nalmefene

  1986cited by this paper
• Quantitative imaging of neuroreceptors in the living human brain.

  1986cited by this paper
• Nalmefene: Intravenous safety and kinetics of a new opioid antagonist

  1986cited by this paper
• Binding of a new opiate antagonist, nalmefene, to rat brain membranes.

  1985cited by this paper
• Prolonged Antagonism of Opioid Action with Intravenous Nalmefene in Man

  1985cited by this paper
• Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration.

  1984cited by this paper
• Imaging dopamine receptors in the human brain by positron tomography.

  1984cited by this paper
• Imaging dopamine receptors in the human brain by positron tomography

  1983cited by this paper
• Pharmacokinetic and biopharmaceutic parameters during enterohepatic circulation of drugs.

  1982cited by this paper
• Metabolism and disposition of naltrexone in man after oral and intravenous administration.

  1981cited by this paper
• Stimulus effects of morphine in the monkey: quantitative analysis of antagonism.

  1980cited by this paper
• The structure-action relationship and kinetics of some naloxone and naltrexone derivatives.

  1976cited by this paper
• Naltrexone: Disposition, metabolism, and effects after acute and chronic dosing

  1976cited by this paper
• Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists.

  1975cited by this paper
• The urinary excretion profile of naltrexone and metabolites in man.

  1974cited by this paper

• Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.

  2023cites this paper
• Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene

  2019cites this paper
• Rat animal models for screening medications to treat alcohol use disorders

  2017influential citation
• A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.

  2016cites this paper
• Functional imaging of neural systems associated with alcohol reward and amphetamine toxicity

  2016cites this paper
• Treatment-refractory substance use disorder: Focus on alcohol, opioids, and cocaine.

  2016cites this paper
• Comparing Nalmefene and Naltrexone in Alcohol Dependence: Are there any Differences? Results from an Indirect Meta-Analysis

  2016cites this paper
• Nalmefene is effective at reducing alcohol seeking, treating alcohol‐cocaine interactions and reducing alcohol‐induced histone deacetylases gene expression in blood

  2016influential citation
• Alterations in the Neurotransmitter Receptor Binding Densities in Cloninger Type 1 and 2 Alcoholics

  2016cites this paper
• Nalmefene for the treatment of alcohol use disorders: recent data and clinical potential

  2016cites this paper
• Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy.

  2016cites this paper
• Functional imaging of neural systems associated with alcohol reward and amphetamine toxicity

  2016cites this paper
• Tratamientos farmacológicos en la coadministración de alcohol y cocaína: efectos en la expresión de genes en el córtex prefrontal de la rata

  2016cites this paper
• Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat

  2015influential citation
• The opioid receptors as targets for drug abuse medication

  2015cites this paper
• Recent Developments in Pharmacotherapy of Alcoholism

  2015cites this paper
• The role of the opioid system in alcohol dependence

  2014cites this paper
• Potent Inhibition of Alcohol Self-Administration in Alcohol-Preferring Rats by a κ-Opioid Receptor Antagonist

  2014cites this paper
• [Nalmefene: a novel pharmacotherapeutic option for alcoholism].

  2014cites this paper
• Nalmefene for the treatment of alcohol dependence: a current update.

  2014cites this paper
• Nalmefene and its use in alcohol dependence.

  2014cites this paper
• Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde

  2013cites this paper
• Nalmefene: A Review of Its Use in the Treatment of Alcohol Dependence

  2013cites this paper
• Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

  2012cites this paper
• Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats.

  2012influential citation
• Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.

  2012cites this paper
• Opioidergic modulation of ethanol self-administration in the ventral pallidum.

  2012cites this paper
• The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats.

  2012cites this paper
• κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats.

  2011cites this paper
• Modulation of alcohol and nicotine responses through the endogenous opioid system.

  2010cites this paper
• Nalmefene for treatment of alcohol dependence

  2010cites this paper
• Operant Self‐Administration Models for Testing the Neuropharmacological Basis of Ethanol Consumption in Rats

  2010cites this paper
• Potency of naltrexone to reduce ethanol self-administration in rats is greater for subcutaneous versus intraperitoneal injection.

  2009influential citation
• Pharmacotherapy of Addictive Disorders

  2009cites this paper
• The Development of ProNeura Technology for the Treatment of Addictions

  2009cites this paper
• Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.

  2009cites this paper
• RESPONSIVE TO OPIOID ANTAGONIST TREATMENT

  2008cites this paper
• Influence of Supercritical Antisolvent Micronization Parameters on Nalmefene HCl Powder Characteristics

  2008cites this paper
• Opioid-Dependent Anticipatory Negative Contrast and Binge-Like Eating in Rats with Limited Access to Highly Preferred Food

  2008cites this paper
• Pharmacological Evidence for a Motivational Role of κ-Opioid Systems in Ethanol Dependence

  2008cites this paper
• High voluntary alcohol consumption, in experimental liver cirrhosis is hardly responsive to opioid antagonist treatment.

  2008cites this paper
• Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.

  2008cites this paper
• Preclinical and clinical pharmacology of alcohol dependence

  2007cites this paper
• [Opioid antagonists and alcohol consumption].

  2007cites this paper
• Development of naltrexone supersensitivity during food-maintained responding enhances naltrexone's ability to reduce ethanol-maintained responding.

  2007cites this paper
• The neurochemistry of the psychological dependence syndrome in addictive diseases of chemical etiology

  2007cites this paper
• Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats.

  2007cites this paper
• REVIEW: Modulation of high alcohol drinking in the inbred Fawn–Hooded (FH/Wjd) rat strain: implications for treatment

  2006cites this paper
• Prolonged Central μ-Opioid Receptor Occupancy after Single and Repeated Nalmefene Dosing

  2005cites this paper
• Naltrexone: preclinical data

  2005cites this paper
• Central Opioid Receptors Differentially Regulate the Nalmefene-Induced Suppression of Ethanol- and Saccharin-Reinforced Behaviors in Alcohol-Preferring (P) Rats

  2004cites this paper
• GABAA and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors

  2004cites this paper
• Implantable technology for long-term delivery of nalmefene for treatment of alcoholism.

  2004cites this paper
• The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum

  2003influential citation
• Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology.

  2003cites this paper
• D1 dopamine receptor regulates alcohol‐motivated behaviors in the bed nucleus of the stria terminalis in alcohol‐preferring (P) rats

  2003cites this paper
• Preclinical Models to Evaluate Potential Pharmacotherapeutic Agents in Treating Alcoholism and Studying the Neuropharmacological Bases of Ethanol‐Seeking Behaviors in Rats

  2002cites this paper
• Research with rats germane to medication for alcoholism: consequences of noncompliance.

  2001cites this paper
• 101 ALCOHOLISM PHARMACOTHERAPY

  2001cites this paper
• Ethanol consumption and reward are decreased in µ-opiate receptor knockout mice

  2001cites this paper
• Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration.

  2001cites this paper
• GABAA Receptors Containing α5 Subunits in the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry

  2001influential citation
• Lession on the hypothalamic arcuate nucleus by estradiol valerate results in a blockade of ethanol-induced locomotion.

  2000cites this paper
• Drug and Alcohol Abuse

  2000cites this paper
• Multidrug Abuse and Dependence

  2000cites this paper
• The delta 2-opioid receptor antagonist naltriben reduces motivated responding for ethanol.

  1999cites this paper
• A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence.

  1999cites this paper