Interaction of deltorphin with opioid receptors: molecular determinants for affinity and selectivity.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Peptides

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0196-9781(93)90006-3PMID 8382810
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.

  1992cited by this paper
• Unique sequence in deltorphin C confers structural requirement for δ opioid receptor selectivity

  1992cited by this paper
• Solution structure of deltorphin I at 265 K: a quantitative NMR study.

  1992cited by this paper
• Opioid δ receptor subtypes are associated with different potassium channels

  1991cited by this paper
• Structure-activity relationships of the delta-opioid-selective agonists, deltorphins.

  1991cited by this paper
• New insights on mu/delta selectivity of opioid peptides: conformational analysis of deltorphin analogues.

  1991cited by this paper
• Structure-activity relationships of the δ-opioid-selective agonists, deltorphins

  1991cited by this paper
• Conformational studies of stereoisomeric 14‐membered cyclic enkephalin analogues containing 1‐naphthyialanine at the fourth position: Chirality effect of leucine at the fifth position on biological activity and receptor selectivity

  1991cited by this paper
• Rusting of the lock and key model for protein-ligand binding.

  1991cited by this paper
• Evidence for two subtypes of delta opioid receptors in rat brain.

  1991cited by this paper
• Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes.

  1991cited by this paper
• Topographical requirements for δ‐selective opioid peptides

  1991cited by this paper
• Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of μ- and δ-opioid receptors and an additional address subsite on the δ-receptor

  1991cited by this paper
• Function of negative charge in the "address domain" of deltorphins.

  1991cited by this paper
• New insights on μ/δ selectivity of opioid peptides: Conformational analysis of deltorphin analogues

  1991cited by this paper
• Evidence for two subtypes of δ opioid receptors in rat brain

  1991cited by this paper
• Topographical requirements for delta-selective opioid peptides.

  1991cited by this paper
• Opioid delta receptor subtypes are associated with different potassium channels.

  1991cited by this paper
• Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes.

  1991cited by this paper
• Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of mu- and delta-opioid receptors and an additional address subsite on the delta-receptor.

  1991cited by this paper
• [D-Ala2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor.

  1991cited by this paper
• Role of peptide backbone conformation on biological activity of chemotactic peptides.

  1991cited by this paper
• Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

  1991cited by this paper
• Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

  1991cited by this paper
• Synthesis and structure-activity relationships of deltorphin analogues.

  1991cited by this paper
• Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.

  1991cited by this paper
• Synthesis, biochemical and pharmacological properties of BUBUC, a highly selective and systemically active agonist for in vivo studies of δ-opioid receptors

  1990cited by this paper
• Examination of the conformational meaning of "delta-address" in the dermenkephalin sequence.

  1990cited by this paper
• Dermorphin interaction with rat brain opioid receptors: involvement of hydrophobic sites in the binding domain.

  1990cited by this paper
• Examination of the conformational meaning of “δ-address” in the dermenkephalin sequence

  1990cited by this paper
• New features of the delta opioid receptor: conformational properties of deltorphin I analogues.

  1990cited by this paper
• New features of the δ opioid receptor : conformational properties of deltorphin I analogues

  1990cited by this paper
• Synthesis, biochemical and pharmacological properties of BUBUC, a highly selective and systemically active agonist for in vivo studies of delta-opioid receptors.

  1990cited by this paper
• Isolation of dermenkephalin from amphibian skin, a high‐affinity (δ‐selective opioid heptapeptide containing a D‐amino acid residue

  1989cited by this paper
• Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency.

  1989cited by this paper
• Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors.

  1989cited by this paper
• Conformational properties of deltorphin: new features of the delta-opioid receptor.

  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• Recent developments in the design of receptor specific opioid peptides

  1989cited by this paper
• Conformational properties of deltorphin: New features of the δ‐opioid receptor

  1989cited by this paper
• Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.

  1989cited by this paper
• Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.

  1989cited by this paper
• Molecular determinants of receptor affinity and selectivity of the natural delta-opioid agonist, dermenkephalin.

  1989cited by this paper
• Conformational determinants of high affinity delta receptor binding of opioid peptides.

  1988cited by this paper
• [3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.

  1988cited by this paper
• Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.

  1988cited by this paper
• A 500-MHz proton nuclear magnetic resonance study of mu opioid peptides in a simulated receptor environment.

  1987cited by this paper
• Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.

  1987cited by this paper
• Molecular mechanics studies of dermorphin.

  1986cited by this paper
• Molecular mechanism of opioid receptor selection.

  1986cited by this paper
• Binding of N-formylated chemotactic peptides in crystals of the Mcg light chain dimer: similarities with neutrophil receptors.

  1985cited by this paper
• Differences in binding properties of mu and delta opioid receptor subtypes from rat brain: kinetic analysis and effects of ions and nucleotides.

  1985cited by this paper
• Differences in Binding Properties of μ and δ Opioid Receptor Subtypes from Rat Brain: Kinetic Analysis and Effects of Ions and Nucleotides

  1985cited by this paper
• Conformational Analysis of Enkephalin and Conformation – Activity Relationships

  1984cited by this paper
• Structure – Activity Relationships in Enkephalin Peptides

  1984cited by this paper
• Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

  1983cited by this paper
• Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors.

  1981cited by this paper
• Structural requirements for specific recognition of mu or delta opiate receptors.

  1981cited by this paper
• Textbook of Pharmacology.

  1980cited by this paper
• Correlation between circular dichroism data and biological activities of 2,5 substituted enkephalin analogues.

  1980cited by this paper
• Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

  1979cited by this paper
• Adrenocorticotropin. 51. Synthesis and properties of analogues of the human hormone with tyrosine residues replaced by 3,5-diiodotyrosine.

  1977cited by this paper
• The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.

  1976cited by this paper
• Binding of flexible ligands to macromolecules

  1975cited by this paper
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  1973cited by this paper
• p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments.

  1973cited by this paper
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  1972cited by this paper
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  1970cited by this paper
• The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis

  1964cited by this paper

• Synthesis, Biological Activity, and NMR‐Based Structural Studies of Deltorphin I Analogs Modified in Message Domain with a New α,α‐Disubstituted Glycines

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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  1995cites this paper
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  1993cites this paper