The Hill analysis and co-ion–driven transporter kinetics

Interaction of multiple ligands with a protein or protein complex is a widespread phenomenon that allows for cooperativity. Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient. Importantly, the Hill analysis of ion-coupled transporters can provide the exact number of transported co-ions, regardless of the extent of the cooperativity in ion binding.

• Publication year

  2015

• Venue

  The Journal of General Physiology

• Publication date

  2015-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1085/jgp.201411332PMID 26009547PMCID 4442790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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