The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Virology

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virol.2013.06.010PMID 23849790PMCID PMC3755019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PNAS Plus Significance Statements

  2013cited by this paper
• The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

  2012cited by this paper
• Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

  2011cited by this paper
• HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

  2011cited by this paper
• Down-regulation of Dicer in hepatocellular carcinoma

  2011cited by this paper
• SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

  2011cited by this paper
• The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells

  2011cited by this paper
• Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates

  2011cited by this paper
• HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.

  2010cited by this paper
• X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells

  2010cited by this paper
• Absence of DICER in Monocytes and Its Regulation by HIV-1*

  2010cited by this paper
• HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.

  2010cited by this paper
• miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

  2009cited by this paper
• Cellular microRNA and P bodies modulate host-HIV-1 interactions.

  2009cited by this paper
• HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1

  2009cited by this paper
• HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

  2009cited by this paper
• Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription

  2009cited by this paper
• HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.

  2009cited by this paper
• Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect

  2009cited by this paper
• Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid

  2009cited by this paper
• Mutation of a Single Residue Renders Human Tetherin Resistant to HIV-1 Vpu-Mediated Depletion

  2009cited by this paper
• Analysis of the Viral Elements Required in the Nuclear Import of HIV-1 DNA

  2009cited by this paper
• HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

  2009cited by this paper
• The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV‐1 Tat

  2009cited by this paper
• RNAi suppressors encoded by pathogenic human viruses.

  2008cited by this paper
• Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

  2008cited by this paper
• Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction

  2008cited by this paper
• Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication

  2008cited by this paper
• HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

  2007cited by this paper
• The HIV1 Protein Vpr Acts to Promote G2 Cell Cycle Arrest by Engaging a DDB1 and Cullin4A-containing Ubiquitin Ligase Complex Using VprBP/DCAF1 as an Adaptor*

  2007cited by this paper
• Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes

  2007cited by this paper
• The Ebola Virus VP35 Protein Is a Suppressor of RNA Silencing

  2007cited by this paper
• Analysis of the Interaction of Primate Retroviruses with the Human RNA Interference Machinery

  2007cited by this paper
• HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase

  2007cited by this paper
• Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication

  2007cited by this paper
• Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration

  2007cited by this paper
• Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.

  2006cited by this paper
• HIV-1 TAR RNA Subverts RNA Interference in Transfected Cells through Sequestration of TAR RNA-binding Protein, TRBP*

  2006cited by this paper
• Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response.

  2006cited by this paper
• Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G

  2006cited by this paper
• Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo

  2006cited by this paper
• Targets for human encoded microRNAs in HIV genes.

  2005cited by this paper
• HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients.

  2005cited by this paper
• TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

  2005cited by this paper
• Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms

  2005cited by this paper
• Suppression of RNA Interference by Adenovirus Virus-Associated RNA

  2005cited by this paper
• Changes in microRNA expression profiles in HIV-1-transfected human cells

  2005cited by this paper
• A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

  2005cited by this paper
• Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.

  2005cited by this paper
• HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle.

  2005cited by this paper
• Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C Complex Is Essential for Vif Function*

  2005cited by this paper
• Human Immunodeficiency Virus Type 1 Vpr Induces the Degradation of the UNG and SMUG Uracil-DNA Glycosylases

  2005cited by this paper
• HIV-1 nef suppression by virally encoded microRNA

  2004cited by this paper
• Upregulation of survivin by HIV-1 Vpr

  2004cited by this paper
• Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells

  2004cited by this paper
• Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis

  2004cited by this paper
• Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-Mediated Inhibition

  2004cited by this paper
• Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway*

  2004cited by this paper
• Vpr-mediated Incorporation of UNG2 into HIV-1 Particles Is Required to Modulate the Virus Mutation Rate and for Replication in Macrophages*

  2004cited by this paper
• Interplay between HIV-1 Vpr and Sp1 Modulates p21WAF1 Gene Expression in Human Astrocytes*

  2004cited by this paper
• HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest.

  2003cited by this paper
• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

  2003cited by this paper
• HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

  2003cited by this paper
• The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

  2003cited by this paper
• Human Immunodeficiency Virus Type 1 Escape from RNA Interference

  2003cited by this paper
• HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

  2003cited by this paper
• Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

  2003cited by this paper
• Induction and Suppression of RNA Silencing by an Animal Virus

  2002cited by this paper
• Modulation of HIV-1 replication by RNA interference

  2002cited by this paper
• Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-Responsive Promoters by Binding Directly to p300/CBP Coactivators

  2002cited by this paper
• A viral protein suppresses RNA silencing and binds silencing‐generated, 21‐ to 25‐nucleotide double‐stranded RNAs

  2002cited by this paper
• HIV-1 Vpr Enhances Viral Burden by Facilitating Infection of Tissue Macrophages but Not Nondividing CD4+ T Cells

  2001cited by this paper
• The Interaction of Vpr with Uracil DNA Glycosylase Modulates the Human Immunodeficiency Virus Type 1 In Vivo Mutation Rate

  2000cited by this paper
• Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.

  2000cited by this paper
• Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression

  2000cited by this paper
• Human Immunodeficiency Virus Type 1 Vpr Contains Two Leucine-Rich Helices That Mediate Glucocorticoid Receptor Coactivation Independently of Its Effects on G2 Cell Cycle Arrest

  2000cited by this paper
• A novel Vpr peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions.

  1999cited by this paper
• Cell Cycle- and Vpr-Mediated Regulation of Human Immunodeficiency Virus Type 1 Expression in Primary and Transformed T-Cell Lines

  1999cited by this paper
• Human immunodeficiency virus type 1 Vpr localization: nuclear transport of a viral protein modulated by a putative amphipathic helical structure and its relevance to biological activity.

  1998cited by this paper
• Viral protein R regulates nuclear import of the HIV‐1 pre‐integration complex

  1998cited by this paper
• Cooperative Actions of HIV-1 Vpr and p53 Modulate Viral Gene Transcription*

  1998cited by this paper
• Human immunodeficiency virus type 1 vpr protein transactivation function: mechanism and identification of domains involved.

  1998cited by this paper
• Diversity of HIV-1 Vpr Interactions Involves Usage of the WXXF Motif of Host Cell Proteins*

  1998cited by this paper
• The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells

  1998cited by this paper
• Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest

  1997cited by this paper
• The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB.

  1996cited by this paper
• Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal Repeat (*)

  1995cited by this paper
• The effect of defective interfering RNAs on the accumulation of tomato bushy stunt virus proteins and implications for disease attenuation.

  1995cited by this paper
• Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.

  1995cited by this paper
• Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

  1995cited by this paper
• Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.

  1994cited by this paper
• The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

  1994cited by this paper
• Regulation of HIV‐1 gene expression

  1991cited by this paper
• Identification of HIV-1 vpr product and function.

  1990cited by this paper

• Vpr, accessory protein of human immunodeficiency virus type 1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1): features of genetic variants of the virus circulating in the Moscow region in 2019-2020.

  2025cites this paper
• Identification of Potential DCAF1 Inhibitors Through Virtual Screening Based on Molecular Docking and Molecular Dynamics Simulations

  2025cites this paper
• Youth Who Control HIV on Antiretroviral Therapy Display Unique Plasma Biomarkers and Cellular Transcriptome Profiles Including DNA Repair and RNA Processing

  2025cites this paper
• CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X

  2024cites this paper
• Cullin-RING ligase 4 in Cancer: Structure, functions, and mechanisms.

  2024cites this paper
• The Role of MicroRNAs in HIV Infection

  2024cites this paper
• HIV-1 Vpr Functions in Primary CD4+ T Cells

  2024cites this paper
• Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.

  2024cites this paper
• E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation

  2023cites this paper
• The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production

  2023cites this paper
• Discovery of Nanomolar DCAF1 Small Molecule Ligands

  2023cites this paper
• Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches.

  2023cites this paper
• MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells

  2022cites this paper
• Trans-acting regulators of ribonuclease activity

  2021cites this paper
• Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

  2021cites this paper
• Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways

  2021cites this paper
• Potential role of micro ribonucleic acids in screening for anal cancer in human papilloma virus and human immunodeficiency virus related malignancies

  2021cites this paper
• Trans-acting regulators of ribonuclease activity.

  2021cites this paper
• Insight in miRNome of Long-Term Non-Progressors and Elite Controllers Exposes Potential RNAi Role in Restraining HIV-1 Infection

  2020cites this paper
• Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr.

  2020cites this paper
• The Quantum microRNA Immunity in Human Virus-Associated Diseases: Virtual Reality of HBV, HCV and HIV-1 Infection, and Hepatocellular Carcinogenesis with AI Machine Learning

  2020cites this paper
• The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.

  2019cites this paper
• HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing

  2019cites this paper
• Illuminating the Role of Vpr in HIV Infection of Myeloid Cells

  2019cites this paper
• Vpr and Its Cellular Interaction Partners: R We There Yet?

  2019cites this paper
• HIV‐1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells

  2019cites this paper
• L'autophagie induite par les glycoprotéines de l'enveloppe du VIH-1 dégrade les peroxysomes : rôle dans la mort des lymphocytes T CD4 non infectés

  2019cites this paper
• HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication

  2019cites this paper
• JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

  2018cites this paper
• Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

  2018cites this paper
• VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation

  2018cites this paper
• Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs

  2018cites this paper
• Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins

  2018cites this paper
• Title Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids , viral vectors and cell lines

  2018cites this paper
• DCAF1 is involved in HCV replication through regulation of miR-122

  2018cites this paper
• DNA unwinding by Viral Protein R Initializes Complicated Cellular Responses in HIV-1 Infection: Defining the Viper’s First Bite

  2018cites this paper
• Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells

  2017cites this paper
• Characterisation of Lentiviral Vpr Function and Mechanism

  2017cites this paper
• Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins

  2017cites this paper
• HIV1‐viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies

  2016cites this paper
• Copyright © 201 R ( Vpr ) mutations : associated evance for clinical pathologies

  2016cites this paper
• Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients.

  2016cites this paper
• HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

  2016cites this paper
• Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.

  2016cites this paper
• 201 on of viral immunity , latency , of selected tumor viruses and HIV

  2015cites this paper
• The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities

  2015cites this paper
• Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes

  2015cites this paper
• The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway.

  2015cites this paper
• HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest*

  2015cites this paper
• RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load

  2015cites this paper
• SURVEY AND SUMMARY The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities

  2015cites this paper
• Investigation of the Role of Myeloid and T Cells in Human Immunodeficiency Virus (HIV) Infection and Persistence in Vivo

  2015influential citation
• MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV

  2015cites this paper
• HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages*

  2015cites this paper
• HIV-1 Vpr enhances proteasomal degradation of MCM10 through the Cul4-DDB1

  2015cites this paper
• HIV-1 Vpr enhances proteasomal degradation of MCM 10 through the Cul 4-DDB 1 [ VprBP ] E 3 ubiquitin ligase to induce G 2 / M cell cycle arrest

  2015cites this paper
• HIV Vpr and Vpx Action Through 1 the CRL 4 Ubiquitin Ligase Complex 2 3 Running Title : CUL 4 A and-B are interchangeable for Vpr and Vpx action 4 5 Byline :

  2014cites this paper
• C URRENT OPINION HIV life cycle, innate immunity and autophagy in the central nervous system

  2014cites this paper
• Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways

  2014cites this paper
• Roles of DNA Damage and its Cellular Response in the Transduction of Human Immunodeficiency Virus-1

  2014cites this paper
• The Ubiquitin-Conjugating System: Multiple Roles in Viral Replication and Infection

  2014influential citation
• Interplay between microRNAs, Toll-like receptors, and HIV-1: potential implications in HIV-1 replication and chronic immune activation.

  2014cites this paper
• MicroRNAs and HIV-1 infection: antiviral activities and beyond.

  2014cites this paper
• HIV life cycle, innate immunity and autophagy in the central nervous system

  2014cites this paper
• CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases

  2014cites this paper
• CRL 4 Ubiquitin Ligase Complex for HIV Vpr and Vpx Action through the Cullin 4 A and Cullin 4 B Are Interchangeable

  2014cites this paper
• Cullin4A and Cullin4B Are Interchangeable for HIV Vpr and Vpx Action through the CRL4 Ubiquitin Ligase Complex

  2014cites this paper
• HIV-1 Vpr—a still “enigmatic multitasker”

  2014cites this paper
• Visualizing Vpr-Induced G2 Arrest and Apoptosis

  2014cites this paper
• HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP

  2013cites this paper
• Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

  2013cites this paper
• Research progress on the function of protein ubiquitination during HIV-1 replication

  year unknowncites this paper