A model of individualized canonical microcircuits supporting cognitive operations

Major cognitive functions such as language, memory, and decision-making are thought to rely on distributed networks of a large number of basic elements, called canonical microcircuits. In this theoretical study we propose a novel canonical microcircuit model and find that it supports two basic computational operations: a gating mechanism and working memory. By means of bifurcation analysis we systematically investigate the dynamical behavior of the canonical microcircuit with respect to parameters that govern the local network balance, that is, the relationship between excitation and inhibition, and key intrinsic feedback architectures of canonical microcircuits. We relate the local behavior of the canonical microcircuit to cognitive processing and demonstrate how a network of interacting canonical microcircuits enables the establishment of spatiotemporal sequences in the context of syntax parsing during sentence comprehension. This study provides a framework for using individualized canonical microcircuits for the construction of biologically realistic networks supporting cognitive operations.

• Publication year

  2017

• Venue

  PLoS ONE

• Publication date

  2017-12-04

• Fields of study

  Medicine, Computer Science

• Identifiers
  DOI 10.1371/journal.pone.0188003PMID 29200435PMCID 5714354
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neural circuit dysfunction in schizophrenia: Insights from animal models.

  2016cited by this paper
• The Computational Properties of a Simplified Cortical Column Model

  2016cited by this paper
• Canonical computations of cerebral cortex.

  2016influential reference
• Transcranial direct current stimulation changes resting state functional connectivity: A large-scale brain network modeling study

  2016cited by this paper
• Brain tissue tessellation shows absence of canonical microcircuits.

  2016cited by this paper
• Grounding language processing on basic neurophysiological principles.

  2015cited by this paper
• Functional constraints in the evolution of brain circuits

  2015cited by this paper
• Networks for memory, perception, and decision-making, and beyond to how the syntax for language might be implemented in the brain.

  2015influential reference
• Towards a “canonical” agranular cortical microcircuit

  2015cited by this paper
• The neocortical circuit: themes and variations

  2015cited by this paper
• A Neural Mass Model with Direct and Indirect Excitatory Feedback Loops: Identification of Bifurcations and Temporal Dynamics

  2015cited by this paper
• Mesoscopic Segregation of Excitation and Inhibition in a Brain Network Model

  2015cited by this paper
• A DCM study of spectral asymmetries in feedforward and feedback connections between visual areas V1 and V4 in the monkey

  2015cited by this paper
• The computational properties of a simplified cortical column model

  2014cited by this paper
• Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex

  2014influential reference
• Self-organized criticality as a fundamental property of neural systems

  2014cited by this paper
• Thinking in circuits: toward neurobiological explanation in cognitive neuroscience

  2014cited by this paper
• Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease

  2014cited by this paper
• From Birdsong to Human Speech Recognition: Bayesian Inference on a Hierarchy of Nonlinear Dynamical Systems

  2013cited by this paper
• Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events.

  2013cited by this paper
• From Oscillatory Transcranial Current Stimulation to Scalp EEG Changes: A Biophysical and Physiological Modeling Study

  2013cited by this paper
• Dynamic causal modelling of lateral interactions in the visual cortex

  2013cited by this paper
• Self-organised transients in a neural mass model of epileptogenic tissue dynamics

  2012cited by this paper
• The Cell-Type Specific Cortical Microcircuit: Relating Structure and Activity in a Full-Scale Spiking Network Model

  2012cited by this paper
• Canonical microcircuits for predictive coding.

  2012cited by this paper
• Normalization as a canonical neural computation

  2011cited by this paper
• Neural Mass Activity, Bifurcations, and Epilepsy

  2011cited by this paper
• Neocortical excitation/inhibition balance in information processing and social dysfunction

  2011cited by this paper
• Bifurcation analysis of neural mass models: Impact of extrinsic inputs and dendritic time constants

  2010cited by this paper
• Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex

  2010cited by this paper
• Prosody meets syntax: the role of the corpus callosum.

  2010cited by this paper
• Robust Short-Term Memory without Synaptic Learning

  2010cited by this paper
• A computational model for cerebral cortical dysfunction in autism spectrum disorders.

  2010cited by this paper
• Motif distribution, dynamical properties, and computational performance of two data-based cortical microcircuit templates.

  2009cited by this paper
• Common circuit defect of excitatory-inhibitory balance in mouse models of autism

  2009cited by this paper
• A synaptic trek to autism.

  2009cited by this paper
• The Dynamic Brain: From Spiking Neurons to Neural Masses and Cortical Fields

  2008cited by this paper
• The criticality hypothesis: how local cortical networks might optimize information processing

  2008cited by this paper
• Modelling of syntactical processing in the cortex

  2007cited by this paper
• Recurrent neuronal circuits in the neocortex.

  2007cited by this paper
• Mapping the matrix: the ways of neocortex.

  2007cited by this paper
• Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex

  2007cited by this paper
• Inhibition Determines Membrane Potential Dynamics and Controls Action Potential Generation in Awake and Sleeping Cat Cortex

  2007cited by this paper
• Computational Aspects of Feedback in Neural Circuits

  2006cited by this paper
• Variability, compensation and homeostasis in neuron and network function

  2006cited by this paper
• Dynamic causal modeling of evoked responses in EEG and MEG

  2006cited by this paper
• Bifurcation Analysis of Jansen's Neural Mass Model

  2006cited by this paper
• Language models based on Hebbian cell assemblies.

  2006cited by this paper
• Frontal latching networks: a possible neural basis for infinite recursion

  2005cited by this paper
• An Analytical Model for the ‘Large, Fluctuating Synaptic Conductance State’ Typical of Neocortical Neurons In Vivo

  2004cited by this paper
• Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites

  2004cited by this paper
• Neuronal circuits of the neocortex.

  2004cited by this paper
• A neurophysiologically-based mathematical model of flash visual evoked potentials

  2004cited by this paper
• Switching between cortical and subcortical sensorimotor pathways.

  2004cited by this paper
• Turning on and off recurrent balanced cortical activity

  2003cited by this paper
• Dynamic causal modelling

  2003cited by this paper
• The Human Cortical White Matter: Quantitative Aspects of Cortico-Cortical Long-Range Connectivity

  2002cited by this paper
• Towards a neural basis of auditory sentence processing.

  2002cited by this paper
• A spatially continuous mean field theory of electrocortical activity

  2002cited by this paper
• A brain perspective on language mechanisms: from discrete neuronal ensembles to serial order.

  2002cited by this paper
• Numerical bifurcation analysis of delay differential equations using DDE-BIFTOOL

  2002cited by this paper
• Stereotypy in neocortical microcircuits.

  2002cited by this paper
• Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

  2002cited by this paper
• Dynamics of large-scale brain activity in normal arousal states and epileptic seizures.

  2002cited by this paper
• Neurocomputational models of working memory

  2000cited by this paper
• Dynamics of Sparsely Connected Networks of Excitatory and Inhibitory Spiking Neurons

  2000cited by this paper
• Bistable Behavior of Inhibitory Neurons Controlling Impulse Traffic through the Amygdala: Role of a Slowly Deinactivating K+ Current

  2000cited by this paper
• A neuronal model of attentional spotlight: parietal guiding the temporal.

  1999cited by this paper
• Alcohol and Neurotransmitter Interactions

  1997cited by this paper
• Chaos in Neuronal Networks with Balanced Excitatory and Inhibitory Activity

  1996cited by this paper
• Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns

  1995influential reference
• A functional microcircuit for cat visual cortex.

  1991cited by this paper
• Distributed hierarchical processing in the primate cerebral cortex.

  1991cited by this paper
• Corticonics: Neural Circuits of Cerebral Cortex

  1991cited by this paper
• The journal of neuroscience : the official journal of the Society for Neuroscience.

  1981cited by this paper
• The temporal structure of spoken language understanding.

  1980cited by this paper
• ON COMPREHENDING SENTENCES: SYNTACTIC PARSING STRATEGIES.

  1979cited by this paper
• Mass action in the nervous system

  1975cited by this paper
• Model of brain rhythmic activity

  1974cited by this paper
• Modality and topographic properties of single neurons of cat's somatic sensory cortex.

  1957cited by this paper
• The organization of behavior: A neuropsychological theory

  1951cited by this paper
• Behavioral/systems/cognitive Neocortical Network Activity in Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition

  year unknowncited by this paper
• Cerebral Cortex Advance Access published February 15, 2006 A Statistical Analysis of Information- Processing Properties of Lamina-Specific

  year unknowncited by this paper

• Combined modulatory effects of excitatory interneurons and pre- and post-feedback inhibition microcircuits on absence seizures

  2025cites this paper
• Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

  2022cites this paper
• Bridging the Gap Between Neurons and Cognition Through Assemblies of Neurons

  2021cites this paper
• Computational Properties of the Visual Microcircuit

  2020cites this paper
• Emergence of cognitive priming and structure building from the hierarchical interaction of canonical microcircuit models

  2019cites this paper
• A Mean-Field Description of Bursting Dynamics in Spiking Neural Networks with Short-Term Adaptation

  2019cites this paper
• How models of canonical microcircuits implement cognitive functions

  2019cites this paper
• Attention modulates topology and dynamics of auditory sensory gating

  2019cites this paper
• Neuromodulation influences synchronization and intrinsic read-out

  2005cites this paper
• Neuromodulation Influences Synchronization and Intrinsic Read-out

  year unknowncites this paper