Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis

One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.

• Publication year

  2009

• Venue

  Molecules

• Publication date

  2009-09-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3390/molecules14103844PMID 19924033PMCID 6255255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.

  2009cited by this paper
• Medicinal plant diversity and uses in the Sango bay area, Southern Uganda.

  2007cited by this paper
• Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.

  2007cited by this paper
• Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity.

  2005cited by this paper
• Flavonol glycosides of Warburgia ugandensis leaves.

  2003cited by this paper
• Field guide to common trees & shrubs of East Africa

  2002cited by this paper
• Dendocarbins A--N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa.

  2001cited by this paper
• In vitro cytostatic activity of 9-demethoxyporothramycin B

  1995cited by this paper
• A comparative study of the stem-bark drimane sesquiterpenes and leaf volatile oils of Warburgia ugandensis and W. stuhlmannii

  1990cited by this paper
• Further Drimane Sesquiterpenes from the Stem Bark of Canella winterana

  1989cited by this paper
• Drimane-type sesqui- and norsesquiterpenoids from polygonum hydropiper

  1985cited by this paper
• Potent army worm antifeedants from the east African Warburgia plants

  1976cited by this paper
• Sesquiterpenoids of Warburgia species—II : Ugandensolide and ugandensidial (cinnamodial)

  1969cited by this paper

• Warburgia Ugandensis: A Review of Compounds and Bioactivity

  2023influential citation
• Phytochemical Content and Antidiabetic Properties of Most Commonly Used Antidiabetic Medicinal Plants of Kenya

  2023cites this paper
• Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids

  2022influential citation
• Chemical and cytotoxic activity of three main sesquiterpenoids from Warburgia ugandensis

  2021cites this paper
• Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS

  2021influential citation
• Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells

  2021cites this paper
• New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Warburgia ugandensis Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes

  2021cites this paper
• Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation

  2021cites this paper
• Isolation, characterization and drug-likeness analysis of bioactive compounds from stem bark of Warburgia ugandensis Sprague

  2020cites this paper
• Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms.

  2020cites this paper
• Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague

  2020influential citation
• A review of 13C NMR spectra of drimane sesquiterpenes

  2019cites this paper
• An efficient callus-based in vitro regeneration protocol for Warburgia Ugandensis Sprague, an important medicinal plant in Africa

  2019cites this paper
• An efficient callus-based in vitro regeneration protocol for Warburgia Ugandensis Sprague, an important medicinal plant in Africa

  2019cites this paper
• A review on the botanical aspects, phytochemical contents and pharmacological activities of Warburgia ugandensis

  2018influential citation
• Diversity in the Phytochemical Profiles of Warburgia ugandensis Sprague from Different Populations across the Kenyan Rift Valley

  2018cites this paper
• Structure-Pungency Relationships and TRP Channel Activation of Drimane Sesquiterpenes in Tasmanian Pepper (Tasmannia lanceolata).

  2017cites this paper
• Variation in Antimicrobial Activity of Warburgia ugandensis Extracts from Different Populations across the Kenyan Rift Valley

  2016cites this paper
• Warburgia: a comprehensive review of the botany, traditional uses and phytochemistry.

  2015cites this paper
• De Novo Transcriptome Analysis of Warburgia ugandensis to Identify Genes Involved in Terpenoids and Unsaturated Fatty Acids Biosynthesis

  2015cites this paper
• A monoclinic form of dendocarbin A: a borderline case of one-dimensional isostructural polymorphism.

  2015cites this paper
• Dendocarbin A: a sesquiterpene lactone from Drimys winteri.

  2014cites this paper
• The genus Warburgia: A review of its traditional uses and pharmacology

  2014cites this paper
• C-Glycosyl flavonoids and coloratane-type sesquiterpene glucosides from the water-soluble fraction of a leaf extract of a Malagasy endemic plant, Cinnamosma fragrans (Canellaceae)

  2013influential citation
• SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

  2013cites this paper
• Distribution of Drimane Sesquiterpenoids and Tocopherols in Liverworts, Ferns and Higher Plants: Polygonaceae, Canellaceae and Winteraceae Species

  2012cites this paper
• Unusual feeding behavior in wild great apes, a window to understand origins of self-medication in humans: role of sociality and physiology on learning process.

  2012cites this paper
• Do animals use natural properties of plants to self-medicate?

  2011cites this paper
• Extraction of Scots Pine with Non-polar solvents

  2011cites this paper
• Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda.

  2011cites this paper
• Local Management of Tuberculosis by Traditional Medicine Practitioners in Lake Victoria Region

  2011cites this paper
• Natural sesquiterpenoids.

  2010cites this paper