Neutral and acidic hydrolysis reactions of the third generation anticancer drug oxaliplatin.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Physical Chemistry B

• Publication date

  2009-01-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jp8086539PMID 19143575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• On the hydrolysis mechanism of the second-generation anticancer drug carboplatin.

  2007cited by this paper
• Direct cellular responses to platinum-induced DNA damage.

  2007cited by this paper
• Hydrolysis of the Anticancer Drug Cisplatin:  Pitfalls in the Interpretation of Quantum Chemical Calculations.

  2006cited by this paper
• Binding of novel azole-bridged dinuclear platinum(II) anticancer drugs to DNA: insights from hybrid QM/MM molecular dynamics simulations.

  2006cited by this paper
• The chemistry of dinuclear analogues of the anticancer drug cisplatin. A DFT/CDM study.

  2006cited by this paper
• Modeling anticancer drug-DNA interactions via mixed QM/MM molecular dynamics simulations.

  2006cited by this paper
• Hydrolysis process of the second generation platinum-based anticancer drug cis-amminedichlorocyclohexylamineplatinum(II).

  2005cited by this paper
• Editorial [Hot Topic: Anti-Cancer Drugs Executive Editor: Elke Bergmann-Leitner]

  2005cited by this paper
• Theoretical study of the suicide inhibition mechanism of the enzyme pyruvate formate lyase by methacrylate.

  2005cited by this paper
• Activation barriers and rate constants for hydration of platinum and palladium square-planar complexes: an ab initio study.

  2004cited by this paper
• Hypersensitivity reactions to oxaliplatin: a case report and the success of a continuous infusional desensitization schedule

  2004cited by this paper
• Energies, structures, and electronic properties of molecules in solution with the C‐PCM solvation model

  2003cited by this paper
• Hydrolysis of oxaliplatin-evaluation of the acid dissociation constant for the oxalato monodentate complex.

  2003cited by this paper
• Current status of oxaliplatin in colorectal cancer.

  2003cited by this paper
• Molecular aspects of resistance to antitumor platinum drugs.

  2002cited by this paper
• Alkaline hydrolysis of oxaliplatin--isolation and identification of the oxalato monodentate intermediate.

  2002cited by this paper
• What Is the “Best” Platinum: Cisplatin, Carboplatin, or Oxaliplatin?

  2001cited by this paper
• Hydrolysis theory for cisplatin and its analogues based on density functional studies.

  2001cited by this paper
• 2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.

  2001cited by this paper
• High-throughput synthesis and screening of platinum drug candidates

  2000cited by this paper
• Oxaliplatin-induced damage of cellular DNA.

  2000cited by this paper
• Oxaliplatin clinical activity: a review.

  2000cited by this paper
• Oxaliplatin. A platinum compound for colorectal cancer?

  2000cited by this paper
• Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

  1999cited by this paper
• Oxaliplatin: a review of its use in the management of metastatic colorectal cancer.

  1999cited by this paper
• Oxaliplatin: a new therapeutic option in colorectal cancer.

  1999cited by this paper
• Oxaliplatin/cisplatin (L-OHP/CDDP) combination in heavily pretreated ovarian cancer.

  1997cited by this paper
• Structural studies of interactions between anticancer platinum drugs and DNA.

  1996cited by this paper
• Single agent activity of oxaliplatin in heavily pretreated advanced epithelial ovarian cancer.

  1996cited by this paper
• Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

  1995cited by this paper
• Role of carrier ligand in platinum resistance of human carcinoma cell lines.

  1993cited by this paper
• Characterization of adducts produced in DNA by isomeric 1,2-diaminocyclohexaneplatinum(II) complexes.

  1989cited by this paper
• Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.

  1988cited by this paper
• The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes.

  1987cited by this paper
• Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation.

  1985cited by this paper
• Antitumor activity of platinum(II) complexes of 1,2-diamino-cyclohexane isomers.

  1980cited by this paper
• Platinum Compounds: a New Class of Potent Antitumour Agents

  1969cited by this paper
• Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

  1965cited by this paper

• Platinum-Based Cytostatics Used in Oncology with Respect to Environmental Fate and Innovative Removal Strategies of Their Metabolites

  2026cites this paper
• The Metal(loid)s' Dilemma. What's the next step for a new era of inorganic molecules in medicine?

  2025cites this paper
• Solution Stability and Storage effect on Selected Metallodrugs: A Multi-Technique Evaluation.

  2025cites this paper
• 3D-printed chitosan-pectin-sodium alginate scaffolds for post-surgical peritoneal wound dressing and sustained delivery of oxaliplatin

  2024cites this paper
• Binding Motifs of Carboplatin and Oxaliplatin with Guanine: A Combined MS/MS, IRMPD, and Theoretical Study.

  2023cites this paper
• Translocation Processes of Pt(II)-Based Drugs through Human Breast Cancer Cell Membrane: In Silico Experiments

  2023cites this paper
• Impact of Chemical Structure and Hydrolysis Mechanisms on the Pharmacological Effects and Toxicity Profiles of Licensed Platinum-Based Drugs

  2023cites this paper
• Theoretical investigation of the hydrolysis and DNA binding of platinum (II) complexes of imidazolidine dioximes

  2023cites this paper
• Synthesis, Characterization, Thermal Analysis, DFT, and Cytotoxicity of Palladium Complexes with Nitrogen-Donor Ligands

  2022cites this paper
• Influence of chemical structure and mechanism of hydrolysis on pharmacological activity and toxicological profile of approved platinum drugs

  2022cites this paper
• Theoretical investigation on hydrolysis mechanism of cis-platin analogous Pt(II)/Pd(II) complex by DFT calculation and molecular docking approach for their interaction with DNA & HSA.

  2022cites this paper
• Iodide Analogs of Arsenoplatins—Potential Drug Candidates for Triple Negative Breast Cancers

  2021cites this paper
• A new bis-pyrazolylpyridine ruthenium(III) complex as a potential anticancer drug: in vitro and in vivo activity in murine colon cancer.

  2021cites this paper
• Review of comparative studies of cytotoxic activities of Pt(II), Pd(II), Ru(II)/(III) and Au(III) complexes, their kinetics of ligand substitution reactions and DNA/BSA interactions

  2020cites this paper
• Blue moon ensemble simulation of aquation free energy profiles applied to mono and bifunctional platinum anticancer drugs

  2020cites this paper
• Molecular Interpretation of Pharmaceuticals’ Adsorption on Carbon Nanomaterials: Theory Meets Experiments

  2020cites this paper
• Theoretical exploration of the photophysical properties of two-component RuII-porphyrin dyes as promising assemblies for a combined antitumor effect.

  2020cites this paper
• The hybrid models, containing hydrolytic and electron-driven processes, in theoretical study of oxaliplatin biotransformation

  2020cites this paper
• Reactivity of arsenoplatin complex versus water and thiocyanate: a DFT benchmark study

  2020cites this paper
• Modulating tumor immunity by metronomic dosing of oxaliplatin incorporated in multiple oral nanoemulsion.

  2020cites this paper
• Recent Research Progress on the Quantum Chemistry Study of Metal Complexes with Anticancer Activity

  2020influential citation
• Studies on the synthesis, characterization, cytotoxic activities and plasmid DNA binding of platinum(II) complexes having 2-subsituted benzimidazole ligands

  2019cites this paper
• Photophysical Exploration of Dual-Approach PtII-BODIPY Conjugates: Theoretical Insights.

  2019cites this paper
• A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition.

  2019cites this paper
• Differences in binding kinetics, bond strength and adduct formation between Pt‐based drugs and S‐ or N‐donor groups: A comparative study using mass spectrometry techniques

  2019cites this paper
• Theoretical determination of the aquation reaction mechanism of cyclometalated benzimidazole Ru(II) and Ir(III) anticancer complexes

  2018cites this paper
• Raman and Infrared Studies of Platinum-Based Drugs: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, and Heptaplatin.

  2018cites this paper
• DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA.

  2017cites this paper
• Synergistic Effects in PtII -Porphyrinoid Dyes as Candidates for a Dual-Action Anticancer Therapy: A Theoretical Exploration.

  2017cites this paper
• New Pt-NNSO core anticancer agents: Structural optimization and investigation of their anticancer activity.

  2017cites this paper
• Direct Determination of Metal Complexes' Interaction with DNA by Atomic Telemetry and Multiscale Molecular Dynamics.

  2017cites this paper
• Improve the anticancer potency of the platinum(II) complexes through functionalized leaving group.

  2017cites this paper
• Hydrolysis mechanism of (N, N) chelated cytotoxic Pt/Pd(II)-dichloro complexes: A theoretical approach

  2017cites this paper
• Kinetic and mechanistic study of substitution on a cytotoxic PtII complex with biologically relevant thiols and a density functional study

  2017cites this paper
• Hydrolysis theory based on density functional studies for cytotoxic Pt(II) and Pd(II) complexes with benzimidazole derivative

  2017cites this paper
• A spectroscopic investigation into the binding of novel platinum(IV) and platium(II) anticancer drugs with DNA

  2017cites this paper
• Kinetic aspects of platinum anticancer agents

  2017cites this paper
• A theoretical investigation on bio-transformation of third generation anti-cancer drug Heptaplatin and its interaction with DNA purine bases

  2017cites this paper
• The role of arsenic in the hydrolysis and DNA metalation processes in an arsenous acid-platinum(ii) anticancer complex.

  2017cites this paper
• Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation

  2016cites this paper
• Hydrolysis mechanism of anticancer drug lobaplatin in aqueous medium under neutral and acidic conditions: A DFT study

  2016cites this paper
• A theoretical investigation on hydrolysis mechanism of biologically relevant Pt(II)/Pd(II) complexes with σ-donor and π-acceptor carrier ligand

  2016cites this paper
• Kinetics and thermochemistry of hydrolysis mechanism of a novel anticancer agent trans-[PtCl2(dimethylamine)(isopropylamine)]: A DFT study

  2016cites this paper
• Synergistic Effects of Metals in a Promising Ru(II) -Pt(II) Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties.

  2016cites this paper
• Triphenylphosphane Pt(II) complexes containing biologically active natural polyphenols: Synthesis, crystal structure, molecular modeling and cytotoxic studies.

  2016cites this paper
• Investigation of the Inertness to Hydrolysis of Platinum(IV) Prodrugs.

  2016cites this paper
• Platinum based radiochemotherapies: Free radical mechanisms and radiotherapy sensitizers.

  2016cites this paper
• Activation and Reactivity of a Bispidine Analogue of Cisplatin: A Theoretical Investigation.

  2016cites this paper
• Non‐covalent Stabilization in Transition Metal Coordination and Organometallic Complexes

  2016cites this paper
• Understanding the ring-opening, chelation and non-chelation reactions between nedaplatin and thiosulfate: a DFT study based on NBO, ETS-NOCV and QTAIM

  2015cites this paper
• Hydration of Two Cisplatin Aqua-Derivatives Studied by Quantum Mechanics and Molecular Dynamics Simulations.

  2015cites this paper
• The conformation effect of the diamine bridge on the stability of dinuclear platinum(II) complexes and their hydrolysis.

  2015cites this paper
• Theoretical study on the mechanism of reaction of novel iminoether-containing Pt(II) anticancer drugs with biological targets

  2015cites this paper
• Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts.

  2015cites this paper
• Atomic level rendering of DNA-drug encounter.

  2014cites this paper
• Atomistic‐Level Portrayal of Drug–DNA Interplay: A History of Courtships and Meetings Revealed by Molecular Simulations

  2014cites this paper
• Experimental and theoretical investigations of the self-association of oxaliplatin.

  2014cites this paper
• Copper-transporting proteins and their interactions with platinum-based anticancer substances

  2013cites this paper
• Hydration of Cisplatin Studied by an Effective Ab Initio Pair Potential Including Solute-Solvent Polarization.

  2013cites this paper
• Mechanism of the cis-[Pt(1R,2R-DACH)(H2O)2]2+ intrastrand binding to the double-stranded (pGpG)·(CpC) dinucleotide in aqueous solution: a computational DFT study.

  2013cites this paper
• Interactions of the aquated forms of the anticancer drug AMD443 with DNA purine bases: A detailed computational approach

  2013cites this paper
• Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1.

  2012cites this paper
• Predicting the interactions of organometallic ruthenium ethylenediamine complexes with mononucleotides: insights from density functional theory

  2012cites this paper
• Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study

  2012cites this paper
• Hydrolysis mechanism of anticancer Pd(II) complexes with coumarin derivatives: a theoretical investigation

  2012cites this paper
• Cisplatin cytotoxicity: a theoretical study of induced mutations.

  2012cites this paper
• Solvent effects and dynamic averaging of 195Pt NMR shielding in cisplatin derivatives.

  2011cites this paper
• Activation of carboplatin by chloride ions: a theoretical investigation

  2011cites this paper
• Stability and proton transfer in DNA base pairs of AMD473–DNA adduct

  2011cites this paper
• Hydrolysis Mechanism of the NAMI-A-type Antitumor Complex (HL)[trans-RuCl4L(dmso-S)] (L=1-methyl-1,2,4-triazole)

  2011cites this paper
• Rhenium(IV) compounds inducing apoptosis in cancer cells.

  2011cites this paper
• Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base.

  2011cites this paper
• Which one among the Pt-containing anticancer drugs more easily forms monoadducts with G and A DNA bases? A comparative study among oxaliplatin, nedaplatin, and carboplatin.

  2011cites this paper
• Activation of the cisplatin and transplatin complexes in solution with constant pH and concentration of chloride anions; quantum chemical study

  2011cites this paper
• trans-Platinum anticancer drug AMD443: A detailed theoretical study by DFT–TST method on the hydrolysis mechanism

  2010cites this paper
• A detailed theoretical DFT study of the hydrolysis mechanism of orally active anticancer drug ZD0473

  2010cites this paper
• Theoretical analysis of trans-[PtCl2(NH3)(thiazole)] and trans-[PtCl2(thiazole)2] binding to biological targets — Factors influence binding kinetics and adduct stability

  2010cites this paper
• A detailed theoretical study of the interaction of thiourea with cis-diaqua(ethylenediamine) platinum(II)

  2009cites this paper
• The second-generation anticancer drug Nedaplatin: a theoretical investigation on the hydrolysis mechanism.

  2009cites this paper