Osteopontin(OPN)-induced increase in human mammary epithelial cell invasiveness is urokinase (uPA)-dependent

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Breast Cancer Research and Treatment

• Publication date

  2001-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/A:1013095329825PMID 11804183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Urokinase plasminogen activator system gene expression is increased in human breast carcinoma and its bone metastases — A comparison of normal breast tissue, non-invasive and invasive carcinoma and osseous metastases

  2000cited by this paper
• Intracellular osteopontin is an integral component of the CD44‐ERM complex involved in cell migration

  2000cited by this paper
• The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.

  2000cited by this paper
• Osteopontin‐induced, integrin‐dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

  2000cited by this paper
• Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer.

  1999cited by this paper
• Urokinase Receptor Interacts with αvβ5 Vitronectin Receptor, Promoting Urokinase-dependent Cell Migration in Breast Cancer

  1999cited by this paper
• CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.

  1999cited by this paper
• Activation Mechanisms of the Urokinase-type Plasminogen Activator Promoter by Hepatocyte Growth Factor/Scatter Factor*

  1999cited by this paper
• Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells

  1999influential reference
• The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype.

  1998cited by this paper
• CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.

  1998cited by this paper
• Osteopontin is a ligand for the alpha4beta1 integrin.

  1998cited by this paper
• Osteopontin expression in a group of lymph node negative breast cancer patients

  1998cited by this paper
• Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.

  1998cited by this paper
• CD44v3,8–10 is involved in cytoskeleton‐mediated tumor cell migration and matrix metalloproteinase (MMP‐9) association in metastatic breast cancer cells

  1998cited by this paper
• ECM and cell surface proteolysis: regulating cellular ecology.

  1997cited by this paper
• ECM and Cell Surface Proteolysis: Minireview Regulating Cellular Ecology

  1997cited by this paper
• Isolation of and effector for metastasis-inducing DNAs from a human metastatic carcinoma cell line

  1997cited by this paper
• The urokinase‐type plasminogen activator system in cancer metastasis: A review

  1997influential reference
• Control of type IV collagenase activity by components of the urokinase–plasmin system: a regulatory mechanism with cell‐bound reactants

  1997cited by this paper
• Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival.

  1997cited by this paper
• Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.

  1996cited by this paper
• Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

  1996cited by this paper
• Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by α9β1 Integrin*

  1996cited by this paper
• Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin.

  1996cited by this paper
• Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

  1996cited by this paper
• Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.

  1996cited by this paper
• Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration.

  1996cited by this paper
• Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration*

  1996cited by this paper
• The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model.

  1996cited by this paper
• The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

  1995cited by this paper
• ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade.

  1995cited by this paper
• A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5.

  1995cited by this paper
• Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions

  1995cited by this paper
• A Biochemical Characterization of the Binding of Osteopontin to Integrins αvβ1 and αvβ5(*)

  1995cited by this paper
• Recombinant GST‐human osteopontin fusion protein is functional in RGD‐dependent cell adhesion

  1994influential reference
• Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells.

  1992cited by this paper
• Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

  1992cited by this paper
• Different patterns of gene expression in ras-resistant and ras-sensitive cells.

  1991cited by this paper
• Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

  1990cited by this paper
• cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN).

  1990cited by this paper
• Tumor progression in four mammary epithelial cell lines derived from the same patient.

  1990cited by this paper
• ras Transfection and expression does not induce progression from tumorigenicity to metastatic ability in mouse LTA cells

  1990cited by this paper
• The human urokinase-plasminogen activator gene and its promoter.

  1985cited by this paper

• SPP1 as a central mediator in the tumor microenvironment: Orchestrating cellular crosstalk, immune evasion, and therapy resistance.

  2026cites this paper
• The Role of Extracellular Matrix Proteins in Breast Cancer

  2022cites this paper
• Osteopontin and breast cancer metastasis: possible role of genistein on the regulation of osteopontin

  2021cites this paper
• Osteopontin Regulates Endometrial Stromal Cell Migration in Endometriosis through the PI3K Pathway

  2020cites this paper
• Human breast milk oligosaccharides attenuate necrotizing enterocolitis in rats by suppressing mast cell accumulation, DPPI activity and TLR4 expression in ileum tissue, and regulating mitochondrial damage of Caco-2 cells.

  2020cites this paper
• Prognostic implications of the co-detection of the urokinase plasminogen activator system and osteopontin in patients with non-small-cell lung cancer undergoing radiotherapy and correlation with gross tumor volume

  2018cites this paper
• Human osteopontin: Potential clinical applications in cancer (Review)

  2017cites this paper
• Osteopontin and vasculogenic mimicry formation are associated with response to neoadjuvant chemotherapy in advanced breast cancer

  2017cites this paper
• Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells

  2017cites this paper
• Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): A Study On Human Salivary Gland Cancer

  2017cites this paper
• Pleural fluid osteopontin, vascular endothelial growth factor, and urokinase-type plasminogen activator levels as predictors of pleurodesis outcome and prognosticators in patients with malignant pleural effusion: a prospective cohort study

  2016cites this paper
• Protein deregulation associated with breast cancer metastasis.

  2015cites this paper
• Original Article Role of plasma osteopontin as a biomarker in locally advanced breast cancer

  2015cites this paper
• Role of plasma osteopontin as a biomarker in locally advanced breast cancer.

  2015cites this paper
• Osteopontin induces soluble urokinase-type plasminogen activator receptor production and release.

  2015cites this paper
• Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin.

  2014cites this paper
• Effect of a 12-Month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: A Randomized Controlled Trial

  2014cites this paper
• Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process.

  2014cites this paper
• Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma.

  2013cites this paper
• Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry.

  2012cites this paper
• Osteopontin Splice Variants Differentially Exert Clinicopathological Features and Biological Functions in Gastric Cancer

  2012cites this paper
• u-PA inhibitor amiloride suppresses peritoneal metastasis in gastric cancer

  2012cites this paper
• Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer

  2012cites this paper
• Elevated circulating levels of osteopontin are associated with metastasis in advanced non-small cell lung cancer

  2011cites this paper
• Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

  2011influential citation
• Osteopontin—An important downstream effector of S100A4‐mediated invasion and metastasis

  2011influential citation
• Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

  2010cites this paper
• Primary breast carcinoma: association of mammographic calcifications with osteopontin expression.

  2010cites this paper
• Effects of osteopontin inhibition on radiosensitivity of MDA-MB-231 breast cancer cells

  2010cites this paper
• Osteopontin: an effector and an effect of tumor metastasis.

  2010cites this paper
• Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.

  2010cites this paper
• Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model

  2010cites this paper
• Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells

  2009cites this paper
• RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells.

  2009cites this paper
• Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells

  2009cites this paper
• Increased expression of osteopontin in patients with triple‐negative breast cancer

  2008cites this paper
• A small interfering RNA targeting osteopontin as gastric cancer therapeutics.

  2008cites this paper
• RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.

  2008cites this paper
• The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms

  2008cites this paper
• Osteopontin Prevents Curcumin-Induced Apoptosis and Promotes Survival Through Akt Activation via αvβ3 Integrins in Human Gastric Cancer Cells

  2008cites this paper
• Osteopontin: regulation in tumor metastasis

  2008cites this paper
• Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1

  2008cites this paper
• The Role of Angiogenic and Wound Repair Factors During CMV‐Accelerated Transplant Vascular Sclerosis in Rat Cardiac Transplants

  2008influential citation
• Metastasis: a current perspective

  2008cites this paper
• Microarray analysis of normal cervix, carcinoma in situ, and invasive cervical cancer: identification of candidate genes in pathogenesis of invasion in cervical cancer

  2007cites this paper
• Stimulation of human breast carcinoma cell invasiveness and urokinase plasminogen activator activity by glucose deprivation.

  2006cites this paper
• Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.

  2006cites this paper
• Osteopontin Induction of Hyaluronan Synthase 2 Expression Promotes Breast Cancer Malignancy*

  2006cites this paper
• Osteopontin is an oncogenic Vav1- but not wild-type Vav1-responsive gene: implications for fibroblast transformation.

  2006influential citation
• Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: Novel post-transcriptional, post-translational regulation

  2006cites this paper
• Tumorigenesis and Neoplastic Progression Role of the Integrin-Binding Protein Osteopontin in Lymphatic Metastasis of Breast Cancer

  2006cites this paper
• BRCA1 Suppresses Osteopontin-mediated Breast Cancer*

  2006cites this paper
• Cell Adhesion Molecules in Tumor Metastasis

  2005cites this paper
• Novel markers for poor prognosis in head and neck cancer

  2005cites this paper
• Contribution of Osteopontin to the Development of Bone Metastasis

  2005cites this paper
• Molecular mechanisms of hepatic metastasis in colorectal cancer

  2005cites this paper
• Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.

  2005cites this paper
• Role of osteopontin in adhesion, migration, cell survival and bone remodeling.

  2004cites this paper
• RESEARCH REVIEW The Role of Osteopontin in Tumor Metastasis

  2004cites this paper
• Tumor cell locomotion: differential dynamics of spontaneous and induced migration in a 3D collagen matrix.

  2004cites this paper
• Transcriptional regulation of osteopontin and the metastatic phenotype: Evidence for a Ras-activated enhancer in the human OPN promoter

  2004cites this paper
• The role of Osteopontin in tumor metastasis.

  2004cites this paper
• Osteopontin and colon cancer progression

  2004cites this paper
• Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.

  2003cites this paper
• Osteopontin Stimulates Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator through Phosphatidylinositol 3-Kinase/Akt Signaling Pathways in Breast Cancer Cells*

  2003cites this paper
• Molecular mechanisms of tumor invasion and metastasis: an integrated view.

  2003cites this paper
• Effects of the ethyl acetate fraction of Spatholobi caulis on tumour cell aggregation and migration

  2003cites this paper
• Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin.

  2003cites this paper
• Clonidine Displacement from Type 1 Imidazoline Receptor by p ‐Aminobenzamidine, the Prototype of Trypsin‐Like Serine Protease Inhibitors

  2002cites this paper
• The Role of Osteopontin in Breast Cancer: Clinical and Experimental Studies

  2001cites this paper