Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

ABSTRACT As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

• Publication year

  2017

• Venue

  Brain Injury

• Publication date

  2017-07-29

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1080/02699052.2016.1274779PMID 28981339PMCID 9351990
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The molecular pathophysiology of concussive brain injury.

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• Long‐term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy

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• Early Mitochondrial Dysfunction after Cortical Contusion Injury

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• Mild traumatic brain injury in U.S. Soldiers returning from Iraq.

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• Mild traumatic brain injury in U.S. soldiers returning from Iraq.

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• The impact of traumatic brain injuries: A global perspective

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  2004cited by this paper
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