A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nucleic Acids Research

• Publication date

  2003-04-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/NAR/GKG319PMID 12682355PMCID PMC153747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repair of oxidative DNA damage

  2007cited by this paper
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  2002cited by this paper
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• A novel uracil‐DNA glycosylase with broad substrate specificity and an unusual active site

  2002influential reference
• Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.

  2001cited by this paper
• Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure.

  2001cited by this paper
• DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes.

  2001cited by this paper
• Structure and function in the uracil-DNA glycosylase superfamily.

  2000influential reference
• The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

  2000cited by this paper
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  2000cited by this paper
• Uracil-DNA Glycosylase in the Extreme Thermophile Archaeoglobus fulgidus *

  2000influential reference
• Lessons learned from structural results on uracil-DNA glycosylase.

  2000cited by this paper
• Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.

  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
• The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

  1998influential reference
• DNA glycosylases in the base excision repair of DNA.

  1997cited by this paper
• DNA glycosylases.

  1997cited by this paper
• TreeView: an application to display phylogenetic trees on personal computers

  1996influential reference
• Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms.

  1996cited by this paper
• The structural basis of specific base-excision repair by uracil–DNA glycosylase

  1996cited by this paper
• A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase

  1996cited by this paper
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  1996influential reference
• Counteracting the mutagenic effect of hydrolytic deamination of DNA 5‐methylcytosine residues at high temperature: DNA mismatch N‐glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF.

  1996cited by this paper
• Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

  1995cited by this paper
• Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.

  1995cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Instability and decay of the primary structure of DNA

  1993cited by this paper
• The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

  1993cited by this paper
• Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.

  1993cited by this paper
• 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

  1991cited by this paper
• MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase

  1991cited by this paper
• Basic local alignment search tool.

  1990influential reference
• Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae.

  1989cited by this paper
• Methanococcus jannaschii sp. nov., an extremely thermophilic methanogen from a submarine hydrothermal vent

  1983cited by this paper
• Base-specific reactions useful for DNA sequencing: methylene blue--sensitized photooxidation of guanine and osmium tetraoxide modification of thymine.

  1978cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues.

  1974influential reference
• Heat-induced deamination of cytosine residues in deoxyribonucleic acid.

  1974cited by this paper
• Base-specific reactions useful for DNA sequencing: methylene blue - sensitized photooxidation of guanine and osmium tetraoxide modification of thymine

  year unknowncited by this paper

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  2025cites this paper
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  2021cites this paper
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  2016cites this paper
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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