Pesticide-induced immunotoxicity: are Great Lakes residents at risk?

Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased risk of immune dysfunction. In spite of the laboratory animal data and evidence from occupational exposures that suggest immunotoxicity, there is no definitive evidence as yet that environmental exposure to these xenobiotics poses a significant threat to the human immune system that is sufficient to predispose residents of the Great Lakes basin to increased disease. However, uncertainties with regard to exposure levels, predictability of tests, suitability of the animal models, and immune reserve cannot be ruled out when making risk assessment decisions such as this.

• Publication year

  1995

• Venue

  Environmental Health Perspectives

• Publication date

  1995-12-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1289/EHP.95103S955PMID 8635440PMCID 1518821
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acceptance and Commitment Therapy Wellness Program for Latine Adults Who Smoke and Have Psychological Distress: Protocol for a Feasibility Study

  2022cited by this paper
• Immunotoxicity--bridging the gap between animal research and human health effects.

  1995cited by this paper
• Immunotoxicity : bridging the gap between animal research and human health effects

  1995cited by this paper
• Immune effects of hexachlorobenzene in the rat: role of metabolism in a 13-week feeding study.

  1995cited by this paper
• Gender-specific effects of prenatal chlordane exposure on myeloid cell development.

  1994cited by this paper
• Blood levels of organochlorine residues and risk of breast cancer.

  1993cited by this paper
• Health effects in man from long-term exposure to pesticides. A review of the 1975-1991 literature.

  1993cited by this paper
• Assessment of cholinergic influences on a primary humoral immune response.

  1992cited by this paper
• Macrophage tumoricidal mechanisms are selectively altered by prenatal chlordane exposure

  1992cited by this paper
• Long-term therapy with low-dose isotretinoin for prevention of basal cell carcinoma: a multicenter clinical trial. Isotretinoin-Basal Cell Carcinoma Study Group.

  1992cited by this paper
• Combined effects of selected insecticides on humoral immune response in mice.

  1992cited by this paper
• DDT and related compounds and risk of pancreatic cancer.

  1992cited by this paper
• 19 – Immunotoxicity of Organophosphorus Compounds

  1992cited by this paper
• Long-term health effects of aldrin and dieldrin. A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin.

  1991cited by this paper
• Long-term health effects of aldrin and dieldrin. A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin.

  1991cited by this paper
• Long-term alteration of adult bone marrow colony formation by prenatal chlordane exposure.

  1990cited by this paper
• Effects of ozone, hexachlorobenzene, and bis(tri-n-butyltin)oxide on natural killer activity in the rat lung.

  1990cited by this paper
• Inhibition of human serum complement activity by diisopropylfluorophosphate and selected anticholinesterase insecticides.

  1989cited by this paper
• Organophosphate exposure inhibits non-specific esterase staining in human blood monocytes.

  1989cited by this paper
• Toxicology studies of a chemical mixture of 25 groundwater contaminants. II. Immunosuppression in B6C3F1 mice.

  1989cited by this paper
• Effects of Inhaled Hexachlorobenzene Aerosols on Rat Pulmonary Host Defenses

  1989cited by this paper
• Immunotoxicity of organophosphorus compounds. Modulation of cell-mediated immune responses by inhibition of monocyte accessory functions.

  1988cited by this paper
• Evaluation of Pesticide Immunotoxicity 4

  1988cited by this paper
• Abrogation of graft-versus-host reaction by dieldrin in mice.

  1988cited by this paper
• The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice.

  1987cited by this paper
• Suppression of humoral immunity in inbred mice by dieldrin.

  1987cited by this paper
• Effect of sub-chronic lindane exposure on humoral and cell-mediated immune responses in albino rats

  1987cited by this paper
• Sub-chronic effect of DDT on humoral immune response to a thymus-independent antigen (bacterial lipopolysaccharide) in mice

  1987cited by this paper
• Macrophage functional activities versus cellular parameters upon sublethal pesticide exposure in mice.

  1987cited by this paper
• Evaluation of Immunotoxicity in a Subchronic Feeding Study of Triphenyl Phosphate

  1987cited by this paper
• Molecular and cellular basis of chemically induced immunotoxicity.

  1987cited by this paper
• Inhibition of human bone marrow-derived stem cell colony formation (CFU-E, BFU-E, and CFU-GM) following in vitro exposure to organophosphates.

  1987cited by this paper
• Direct suppression of cultured spleen cell responses by chlordane and the basis for differential effects on in vivo and in vitro immunocompetence.

  1987cited by this paper
• Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,S-trimethyl phosphorothioate: generation of suppressive macrophages from treated animals.

  1987cited by this paper
• Effects of sub-chronic DDT exposure on humoral and cell-mediated immune responses in albino rats

  1987cited by this paper
• Summary of illnesses and injuries reported in California by physicians in 1986 as potentially related to pesticides.

  1987cited by this paper
• Immunotoxicity of carcinogenic pesticides and related chemicals

  1987cited by this paper
• An immunotoxicological evaluation of gamma-chlordane.

  1986cited by this paper
• Environmental Health Criteria 44. Mirex. 70 Seiten, 8 Tab. World Health Organization, Genf 1984. Preis: 9,– Sfr

  1986cited by this paper
• An immunotoxicological evaluation of ?-chlordane*1, *2

  1986cited by this paper
• Health surveillance and biological monitoring of pesticide formulators in India.

  1986cited by this paper
• Specific features of the changes in the health status of female workers exposed to pesticides in greenhouses.

  1986cited by this paper
• Suppression of MHV3 virus-activated macrophages by dieldrin

  1986cited by this paper
• Organophosphorus pesticide immunotoxicity: effects of O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems.

  1986cited by this paper
• Subacute toxicity of hexachlorobenzene.

  1986cited by this paper
• Subacute toxicity of hexachlorobenzene.

  1986cited by this paper
• Is it safe to drive SUVs?

  1986cited by this paper
• Sub-chronic effect of DDT on humoral immune response in mice

  1986cited by this paper
• The effect of prenatal chlordane exposure on specific anti-influenza cell-mediated immunity.

  1985cited by this paper
• Increased susceptibility to mouse hepatitis virus 3 of peritoneal macrophages exposed to dieldrin☆

  1985cited by this paper
• Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,S-trimethyl phosphorothioate. I. Characterization of the immune cell population affected.

  1985cited by this paper
• Influenza type A virus infection of mice exposed in utero to chlordane; survival and antibody studies.

  1985cited by this paper
• Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,S-trimethyl phosphorothioate. II. Effect on the ability of murine macrophages to present antigen.

  1985cited by this paper
• [Serum levels of immunoglobulins and C 3 component of complement in persons occupationally exposed to chlorinated pesticides].

  1985cited by this paper
• The effect of prenatal chlordane exposure on the delayed hypersensitivity response of BALB/c mice.

  1985cited by this paper
• Alterations of alveolar macrophage function and level of bronchopulmonary protease inhibitors in O,O,S-trimethyl phosphorothioate-induced lung injury.

  1985cited by this paper
• Effects of subchronic treatment with O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems.

  1985cited by this paper
• Industrial exposure to organophosphorus compounds. Studies of a group of workers with a decrease in esterase-staining monocytes.

  1985cited by this paper
• In vitro effects of malathion and O,O,S-trimethyl phosphorothioate on cytotoxic T-lymphocyte responses

  1985cited by this paper
• Neutrophil function and infectious disease in workers occupationally exposed to phosphoorganic pesticides: role of mononuclear-derived chemotactic factor for neutrophils.

  1984cited by this paper
• The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.

  1983cited by this paper
• Lung cancer and other causes of death among licensed pesticide applicators.

  1983cited by this paper
• Offspring mortality and maternal lung pathology in female rats fed hexachlorobenzene.

  1982cited by this paper
• Immunoteratology of chlordane: cell-mediated and humoral immune responses in adult mice exposed in utero.

  1982cited by this paper
• Toxic chemicals in the Great Lakes

  1979cited by this paper
• Effect of hexachlorobenzene on the immune system of rats following combined pre- and postnatal exposure.

  1979cited by this paper
• Effects of pesticides on human leukocyte functions.

  1979cited by this paper
• Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl- and hexachlorobenzene-treated mice

  1978cited by this paper
• Studies on the immunosuppressive effect of organochlorine and organophosphoric pesticides in subacute experiments.

  1978cited by this paper
• Pesticide Effects on the Immune Response and Metabolic Activity of Chicken Lymphocytes 1

  1977cited by this paper
• Toxic effects of hexachlorobenzene after daily administration to beagle dogs for one year.

  1977cited by this paper
• Polychlorinated biphenyl and hexachlorobenzene induced humoral immunosuppression.

  1977cited by this paper
• Immunological surveillance and toxicity in mice exposed to the organophosphate pesticide, leptophos.

  1976cited by this paper
• Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, aroclor 1254, carbaryl, carbofuran, and methylparathion.

  1975cited by this paper
• Antibody-mediated immunity in the presence of Mirex and DDT.

  1974cited by this paper
• Relationship of pesticides to immune responses.

  1973cited by this paper
• Relationship of pesticides to immune responses.

  1973cited by this paper

• An examination of organochlorine insecticide exposures and associated cancer risks among the agricultural health study (AHS) farm spouses

  2019cites this paper
• A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides

  2017cites this paper
• Obesity and Endometrial Cancer: Is There aRole for Immunotoxicity?

  2016cites this paper
• A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences

  2015cites this paper
• A modeling assessment of contaminant fate in the Bay of Quinte, Lake Ontario: Part 2. Organic chemicals

  2014cites this paper
• Cytokine patterns in greenhouse workers occupationally exposed to α-cypermethrin: an observational study.

  2013cites this paper
• Multi-biomarker approach in wild European bullhead, Cottus sp., exposed to agricultural and urban environmental pressures: practical recommendations for experimental design.

  2012cites this paper
• Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study

  2011cites this paper
• Immunotoxicity of pyrethroid metabolites in an in vitro model.

  2010cites this paper
• Pesticide sales and adult male cancer mortality in Brazil.

  2009cites this paper
• Relationship Between Cholinesterase Inhibitor Insecticides In Human Blood And Insecticides Residues In Drinking Water In Mansoura City- Egypt

  2007cites this paper
• Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

  2007cites this paper
• Organochlorines and risk of non‐Hodgkin lymphoma

  2007cites this paper
• Organophosphates, Carbamates, and the Immune System

  2006cites this paper
• Alcohol-Related Diseases of the Esophagus and Stomach

  2006cites this paper
• Environmental health and primary health care: towards a new workforce model.

  2005cites this paper
• Alkohol und Krebs

  2005cites this paper
• Alkohol und Magen

  2005cites this paper
• Alkohol und Ösophagus

  2005cites this paper
• PESTICIDES AND CHILD HEALTH: EVIDENCE FROM HISPANIC CHILDREN IN THE U.S.

  2004cites this paper
• Suppression of Immune Function and Susceptibility to Infections in Humans: Association of Immune Function with Clinical Disease

  2004cites this paper
• Pesticides and Child Health : Evidence from Hispanic Children in the U .

  2004cites this paper
• 1 Proposal to Sequence the Nasonia Genome

  2004cites this paper
• Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.

  2003cites this paper
• Identification and Characterization of Organotin Inducible Bacterial Genes

  2003cites this paper
• Pesticide-Induced Immunotoxicity: Are Humans at Risk?

  2002cites this paper
• Isomalathion and related compounds as active site probes of acetylcholinesterase

  2001cites this paper
• Approaches to detecting immunotoxic effects of environmental contaminants in humans.

  2001cites this paper
• Environmental fate and toxicology of organophosphate pesticides

  2000cites this paper
• Supercritical fluid extraction of organochlorine pesticides in eggs.

  1999cites this paper
• A critique of the World Resources Institute's report "Pesticides and the immune system: the public health risks".

  1998cites this paper
• Environmental endocrine disruption: an effects assessment and analysis.

  1998cites this paper
• Estrogen-regulated non-reproductive behaviors and breast cancer risk: Animal models and human studies

  1997cites this paper