The Spindle Assembly Checkpoint and Its Defects in Human Cancer

No abstract is available for this paper.

• Publication year

  2003

• Venue

  International Journal of Human Genetics

• Publication date

  2003-04-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/09723757.2003.11885833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell cycle trials in Salamanca: workshop on G2/M progression and associated checkpoints.

  2002cited by this paper
• Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.

  2002cited by this paper
• The spindle checkpoint: structural insights into dynamic signalling

  2002cited by this paper
• Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint

  2002influential reference
• Control of localization of a spindle checkpoint protein, Mad2, in fission yeast.

  2002cited by this paper
• Characterization of Regions in hsMAD1 Needed for Binding hsMAD2

  2002influential reference
• Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

  2002influential reference
• BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1

  2002influential reference
• Cell cycle trials in Salamanca

  2002cited by this paper
• Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

  2001cited by this paper
• CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells.

  2001cited by this paper
• Erratum: Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas (Acta Neuropathologica (2001) vol. 101 (297-304))

  2001cited by this paper
• MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

  2001cited by this paper
• Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

  2001cited by this paper
• Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

  2001cited by this paper
• Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

  2001cited by this paper
• Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas

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• Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.

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• Tumor suppressor p53: regulation and function.

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• Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2.

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• Exit from mitosis: spindle pole power.

  2000cited by this paper
• Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis.

  2000cited by this paper
• CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

  2000cited by this paper
• CENP-E as an essential component of the mitotic checkpoint in vitro.

  2000cited by this paper
• Bub 3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

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• Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

  1999cited by this paper
• The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.

  1999cited by this paper
• Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers

  1999cited by this paper
• Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

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• Retention of the BUB3 checkpoint protein on lagging chromosomes.

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• Bifurcation of the mitotic checkpoint pathway in budding yeast.

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• Mutations of mitotic checkpoint genes in human cancers

  1998cited by this paper
• Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores

  1998cited by this paper
• The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

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• Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

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• Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.

  1998cited by this paper
• Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions.

  1998cited by this paper
• Characterization of the Kinetochore Binding Domain of CENP-E Reveals Interactions with the Kinetochore Proteins CENP-F and hBUBR1

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• Mad2 transiently associates with an APC/p55Cdc complex during mitosis.

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• Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption

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• Identification of a Human Mitotic Checkpoint Gene: hsMAD2

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• Mitotic forces control a cell-cycle checkpoint

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• Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

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• Regulatory mechanisms governing mammary epithelial and progenitor cell growth

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• In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint

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• Systems Biology of Mitosis

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• A historical perspective on familial cancer: results and vision of the Polyposis Center Project

  2004cites this paper