Crossover regions in foot-and-mouth disease virus (FMDV) recombinants correspond to regions of high local secondary structure

SummaryThe RNA genome of foot-and-mouth disease virus (FMDV) was analysed for the degree of inverted complementarity and thus potential secondary structure using the procedure of Pustell and Kafatos [Nucleic Acids Res (1982) 10: 4765–4782]. Regions of crossover in 42 FMDV recombinants [King et al. (1985) Virus Res 3: 373–384; Saunders et al. (1985) J Virol 56: 921–929] and regions lacking crossovers were assigned an average secondary structure score against which the number of observed recombinants was plotted. In general it was found that the mean value of potential secondary structure is significantly higher in crossover zones than in recombination-free zones. Recombination increased much more steeply with increasing secondary structure in the part of the genome coding for non-structural proteins than in the 5′ third of the genome coding for structural proteins.

• Publication year

  2005

• Venue

  Archives of Virology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF01315570PMID 2848475PMCID 7086634
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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