Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Oncology Report

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/or.2013.2469PMID 23673431
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer statistics, 2012

  2012cited by this paper
• Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer

  2011cited by this paper
• Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

  2011cited by this paper
• Phase II evaluation of early oral estramustine, oral etoposide, and intravenous paclitaxel combined with hormonal therapy in patients with high-risk metastatic prostate adenocarcinoma: Southwest Oncology Group S0032.

  2011cited by this paper
• Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer.

  2011cited by this paper
• Antitumor Effects of Ginkgolic Acid in Human Cancer Cell Occur via Cell Cycle Arrest and Decrease the Bcl-2/Bax Ratio to Induce Apoptosis

  2010cited by this paper
• Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety.

  2010cited by this paper
• Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin.

  2009cited by this paper
• Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells.

  2009cited by this paper
• Quercetin Induces Oxidative Stress and Potentiates the Apoptotic Action of 2-Methoxyestradiol in Human Hepatoma Cells

  2009cited by this paper
• Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.

  2008cited by this paper
• Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 study.

  2008cited by this paper
• Increased expression ratio of Bcl-2/Bax is associated with crocin-mediated apoptosis in bovine aortic endothelial cells.

  2007cited by this paper
• Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.

  2007cited by this paper
• Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

  2006cited by this paper
• A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer

  2005cited by this paper
• Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression

  2005cited by this paper
• Antihypertensive Efficacy of Angiotensin Receptor Blockers in Combination With Hydrochlorothiazide: A Review of the Factorial‐Design Studies

  2004cited by this paper
• Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation.

  2004cited by this paper
• Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer.

  2004cited by this paper
• Identification of a novel Bcl‐xL phosphorylation site regulating the sensitivity of taxol‐ or 2‐methoxyestradiol‐induced apoptosis

  2003cited by this paper
• Tumor chemosensitization strategies based on apoptosis manipulations.

  2003cited by this paper
• 2‐methoxyestradiol blocks cell‐cycle progression at G2/M phase and inhibits growth of human prostate cancer cells

  2001cited by this paper
• BCL-2 family members and the mitochondria in apoptosis.

  1999cited by this paper
• The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

  1994cited by this paper
• Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.

  1984cited by this paper

• Nanoparticle-based strategies with bioactive compounds for targeting oxidative stress in therapeutic interventions: A comprehensive review

  2025cites this paper
• The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens

  2024cites this paper
• Quercetin: derivatives, biosynthesis, biological activity, pharmacological and therapeutic effects

  2023cites this paper
• Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines

  2023cites this paper
• The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

  2023cites this paper
• Combination Modality Using Quercetin to Enhance the Efficacy of Docetaxel in Prostate Cancer Cells

  2023cites this paper
• Paclitaxel and docetaxel resistance in prostate cancer: Molecular mechanisms and possible therapeutic strategies.

  2023cites this paper
• Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

  2023cites this paper
• A Renewed Concept on the MAPK Signaling Pathway in Cancers: Polyphenols as a Choice of Therapeutics.

  2022cites this paper
• The Role and Mechanisms of Action of Natural Compounds in the Prevention and Treatment of Cancer and Cancer Metastasis.

  2022influential citation
• Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

  2021cites this paper
• Combination of quercetin and 2-methoxyestradiol inhibits epithelial–mesenchymal transition in PC-3 cell line via Wnt signaling pathway

  2021cites this paper
• Redox-Modulating Capacity and Antineoplastic Activity of Wastewater Obtained from the Distillation of the Essential Oils of Four Bulgarian Oil-Bearing Roses

  2021cites this paper
• Nutritional Evaluation, Antioxidant, Anticancer and Antimicrobial Activities of Egyptian amhat date palm fruit

  2021cites this paper
• A review on pharmacological activities and synergistic effect of quercetin with small molecule agents.

  2021cites this paper
• Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance

  2021cites this paper
• Research Progress in Flavonoid Anticancer Drugs including synergy with other Approaches.

  2020cites this paper
• Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways

  2020cites this paper
• Current Aspects of Flavonoids: Their Role in Cancer Treatment

  2019cites this paper
• Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo.

  2019cites this paper
• Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models.

  2019cites this paper
• Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

  2019cites this paper
• Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy

  2019cites this paper
• Mechanisms of anti-prostate cancer by Polyphenols compounds

  2019cites this paper
• Chinese Medicines in the Treatment of Prostate Cancer: From Formulas to Extracts and Compounds

  2018cites this paper
• Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy.

  2017cites this paper
• Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells.

  2017cites this paper
• Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.

  2016cites this paper
• Molecular mechanisms of action of quercetin in cancer: recent advances

  2016cites this paper
• Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway.

  2016cites this paper
• Flavonoids and Prostate Cancer

  2016cites this paper
• 2-Methoxyestradiol Induces Vasodilation by Stimulating NO Release via PPARγ/PI3K/Akt Pathway

  2015cites this paper
• Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review).

  2015cites this paper
• Quercetin-6-C-β-D-glucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor.

  2015cites this paper
• Synergistic Effects of Dietary Natural Products as Anti-Prostate Cancer Agents

  2015cites this paper
• Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth

  2015cites this paper
• Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts

  2015cites this paper
• Effect of Sedum sarmentosum BUNGE extract on aristolochic acid-induced renal tubular epithelial cell injury.

  2014cites this paper
• Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice

  2014cites this paper
• Protection effect of Emodin pretreatment on intestinal I-RI damage of intestinal mucosa in ratsa

  2014cites this paper
• Sedum sarmentosum Bunge extract exerts renal anti-fibrotic effects in vivo and in vitro.

  2014influential citation
• Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling.

  2013cites this paper