Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.111.234492PMID 21868699PMCID PMC3350106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Mechanisms Mediating Atherosclerosis Susceptibility at the Chromosome 9p21 Locus

  2011cited by this paper
• 9p21 DNA variants associated with Coronary Artery Disease impair IFNγ signaling response

  2011cited by this paper
• Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

  2011cited by this paper
• Macrophage death and defective inflammation resolution in atherosclerosis

  2010cited by this paper
• Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

  2010cited by this paper
• Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertension.

  2010cited by this paper
• Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

  2010cited by this paper
• Targeted Deletion of the 9p21 Noncoding Coronary Artery Disease Risk Interval in Mice

  2010cited by this paper
• ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1.

  2010cited by this paper
• ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21

  2010cited by this paper
• p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis.

  2010cited by this paper
• Chromosome 9p21 and coronary artery disease.

  2010cited by this paper
• Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

  2010cited by this paper
• Imaging inflammation in stroke using magnetic resonance imaging.

  2010cited by this paper
• ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

  2010cited by this paper
• Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging

  2009cited by this paper
• Impact of Monocyte Chemoattractant Protein-1 Deficiency on Cerebral Aneurysm Formation

  2009cited by this paper
• Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants

  2009cited by this paper
• Genomic Views of Distant-Acting Enhancers

  2009cited by this paper
• Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke

  2009cited by this paper
• The 9p21 Myocardial Infarction Risk Allele Increases Risk of Peripheral Artery Disease in Older People

  2009cited by this paper
• INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

  2009cited by this paper
• Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

  2009cited by this paper
• Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

  2009cited by this paper
• The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

  2008cited by this paper
• Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21

  2008cited by this paper
• Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

  2008cited by this paper
• Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

  2008cited by this paper
• Network-based gene expression analysis of intracranial aneurysm tissue reveals role of antigen presenting cells.

  2008cited by this paper
• Athsq1 Is an Atherosclerosis Modifier Locus With Dramatic Effects on Lesion Area and Prominent Accumulation of Versican

  2008cited by this paper
• Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2−/− Mice: Evidence for Independent Chemokine Functions in Atherogenesis

  2008cited by this paper
• Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.

  2007cited by this paper
• A common variant on chromosome 9p21 affects the risk of myocardial infarction.

  2007cited by this paper
• A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

  2007cited by this paper
• Genomewide association analysis of coronary artery disease.

  2007cited by this paper
• Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.

  2007cited by this paper
• A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

  2007cited by this paper
• The regulation of INK4/ARF in cancer and aging.

  2006cited by this paper
• Leukocytosis and Ischemic Vascular Disease Morbidity and Mortality: Is It Time to Intervene?

  2005cited by this paper
• Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

  2005cited by this paper
• Review Principles of Tumor Suppression Erties of " Classic " Tumor Suppressor Genes. First, They

  2004cited by this paper
• Relationship between physical fitness and lifestyle behaviour in healthy young men

  2004cited by this paper
• Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model

  2001cited by this paper
• Atherosclerosis : Vascular biology

  2000cited by this paper
• Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.

  1998cited by this paper
• White blood cell counts in persons aged 65 years or more from the Cardiovascular Health Study. Correlations with baseline clinical and demographic characteristics.

  1996cited by this paper
• Role of the INK4a locus in tumor suppression and cell mortality.

  1996cited by this paper
• Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E.

  1995cited by this paper
• Leukocytosis in rabbits with diet-induced atherosclerosis.

  1991cited by this paper
• Enhanced monocyte progenitor cell proliferation in bone marrow of hyperlipemic swine.

  1989cited by this paper

• The gut–heart axis in coronary artery disease: a scoping and narrative review of sex-based microbial and metabolic disparities

  2026cites this paper
• Integrated analysis of the blood metallome and DNA methylation, gene expression, and protein levels of immune-associated genes in residents from mining region

  2026cites this paper
• ICI-induced cardiovascular toxicity: mechanisms and immune reprogramming therapeutic strategies

  2025cites this paper
• Associations of tumour somatic mutations with cancer-associated venous thromboembolism

  2025cites this paper
• Epigenetic-ncRNA crosstalk in atherosclerosis: Mechanisms, disease progression and therapeutic potential (Review)

  2025cites this paper
• The Pleiotropic Effect of ANRIL in Glaucoma and Cardiovascular Disease

  2025cites this paper
• CDKN2B-AS1 polymorphism rs1333049 is associated with advanced carotid artery atherosclerosis in a Slovenian population

  2024influential citation
• DNA Methylation Pattern and mRNA Expression Level of E-Cadherin and P16 Genes in Thrombotic Disorders

  2024cites this paper
• The mechanisms of Chr.9p21.3 risk locus in coronary artery disease - where are we today?

  2024cites this paper
• Identification of key genes for cuproptosis in carotid atherosclerosis

  2024cites this paper
• The senescent marker p16INK4a enhances macrophage foam cells formation

  2024cites this paper
• The Effect of Cuproptosis-Related Proteins on Macrophage Polarization in Mesothelioma is Revealed by scRNA-seq

  2024cites this paper
• Long noncoding RNAs in cardiovascular disease

  2023cites this paper
• Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation

  2023cites this paper
• Sex differences in the genetic and molecular mechanisms of coronary artery disease.

  2023cites this paper
• Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

  2023cites this paper
• Comprehensive in-silico analysis of deleterious SNPs in APOC2 and APOA5 and their differential expression in cancer and cardiovascular diseases conditions.

  2023cites this paper
• Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma

  2022cites this paper
• Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms

  2022cites this paper
• Metabolic regulation of macrophage proliferation and function in atherosclerosis

  2021cites this paper
• Association between rs3088440 (G > A) polymorphism at 9p21.3 locus with the occurrence and severity of coronary artery disease in an Iranian population

  2021cites this paper
• Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

  2020cites this paper
• Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes

  2020cites this paper
• 9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology

  2019cites this paper
• Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.

  2019cites this paper
• Changes in CDKN2A/2B expression associate with T‐cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus

  2019cites this paper
• Cellular Senescence: Aging, Cancer, and Injury.

  2019cites this paper
• Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

  2019cites this paper
• Genetics of Common, Complex Coronary Artery Disease.

  2019cites this paper
• MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.

  2019cites this paper
• Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes

  2019cites this paper
• The beneficial effects of the Lab4 probiotic consortium in atherosclerosis

  2019cites this paper
• Genetic Causes of Cardiac Disease

  2019cites this paper
• Roles of the Chr.9p21.3 ANRIL Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification

  2018cites this paper
• The HACD4 haplotype as a risk factor for atherosclerosis in males.

  2018cites this paper
• Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers

  2018cites this paper
• Molecular functions and specific roles of circRNAs in the cardiovascular system

  2018cites this paper
• Monocyte-Macrophages and T Cells in Atherosclerosis.

  2017cites this paper
• Senescence in Health and Disease.

  2017cites this paper
• The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment

  2017cites this paper
• Genetics and Genomics of Coronary Artery Disease

  2016cites this paper
• Senescent intimal foam cells are deleterious at all stages of atherosclerosis

  2016cites this paper
• Deficient CDKN2B Expression: A Double Hit for PAD.

  2016cites this paper
• Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr −/−, Cdkn2a-Deficient Mice

  2016cites this paper
• With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.

  2016cites this paper
• Cdkn2a Orchestrates Platelet Production and Reactivity in Atherosclerosis.

  2016cites this paper
• The Impact of Aging on Cancer Progression and Treatment

  2016cites this paper
• The Chromosome 9 p 21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease : An Eleven-Year Follow-Up Study

  2015cites this paper
• Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

  2015cites this paper
• Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling.

  2015cites this paper
• Gene Expression Profiling Reveals Distinct Molecular Signatures Associated With the Rupture of Intracranial Aneurysm

  2014cites this paper
• Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating p53

  2014cites this paper
• Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.

  2014cites this paper
• The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease: An Eleven-Year Follow-Up Study

  2014cites this paper
• INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

  2014cites this paper
• Ageing as developmental decay: insights from p16(INK4a.).

  2014cites this paper
• Cellular senescence: from physiology to pathology

  2014cites this paper
• From genotype to phenotype in human atherosclerosis - recent findings

  2013cites this paper
• Nutrigenetics and Nutrigenomics of Atherosclerosis

  2013cites this paper
• Expanded Granulocyte/Monocyte Compartment in Myeloid-Specific Triple FoxO Knockout Increases Oxidative Stress and Accelerates Atherosclerosis in Mice

  2013cites this paper
• Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging

  2013influential citation
• The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a

  2013influential citation
• Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation

  2013cites this paper
• The Molecular Balancing Act of p16INK4a in Cancer and Aging

  2013cites this paper
• OutFOXing myeloid cells in atherosclerosis with FoxOs.

  2013cites this paper
• Stem cells: Down's syndrome link to ageing

  2013cites this paper
• Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation

  2013cites this paper
• Molecular biology of atherosclerosis.

  2013cites this paper
• An Investigation of Circular RNAs on a Genome-Wide Scale

  2013cites this paper
• Human-Mouse Genomic Homologies for Coronary Artery Disease – Associated Loci : Availability of Mutant Mouse Models

  2012cites this paper
• Macrophage proliferation and apoptosis in atherosclerosis

  2012cites this paper
• Beyond Genome-Wide Association Studies: The Usefulness of Mouse Genetics in Understanding the Complex Etiology of Atherosclerosis

  2012cites this paper
• Experimental models for Barrett ’ s esophagus and esophageal adenocarcinoma

  2012cites this paper
• Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations.

  2012cites this paper
• Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease

  2012cites this paper
• Review: A Meta-Analysis of GWAS Studies and Age-Associated Diseases

  2012cites this paper
• Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma.

  2012cites this paper
• Bone Marrow p16INK4a-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development

  2012influential citation
• Chromosome 9p21 Are Associated with Coronary Artery Disease

  2012cites this paper
• Increased gene dosage of the Ink4/Arf locus does not attenuate atherosclerosis development in hypercholesterolaemic mice.

  2012cites this paper
• Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

  2012cites this paper
• Review: a meta‐analysis of GWAS and age‐associated diseases

  2012cites this paper
• Genetics of atherosclerosis.

  2012cites this paper
• driven murine macrophage proliferation in vivo - as essential for IL-4 dependent microRNAs identifies PI3K/Akt signaling - α Induction of IL-4R

  2012cites this paper
• Editorial Outfoxing Myeloid Cells in Atherosclerosis with Foxos

  year unknowncites this paper
• Article in Press G Model Mechanisms of Ageing and Development with Mouse Age Comes Wisdom: a Review and Suggestions of Relevant Mouse Models for Age-related Conditions Article in Press G Model

  year unknowncites this paper