SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2012-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.00486.2011PMID 22234371PMCID PMC3311292
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

  2011influential reference
• SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons

  2011cited by this paper
• Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects.

  2010cited by this paper
• A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity

  2010cited by this paper
• Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

  2010cited by this paper
• Individualised incretin-based treatment for type 2 diabetes.

  2010cited by this paper
• In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.

  2010cited by this paper
• One SUMO is sufficient to silence the dimeric potassium channel K2P1

  2010cited by this paper
• Development of FRET Assay into Quantitative and High-throughput Screening Technology Platforms for Protein–Protein Interactions

  2010cited by this paper
• Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

  2009cited by this paper
• Sumoylation Regulates the Transcriptional Activity of MafA in Pancreatic β Cells*

  2009cited by this paper
• SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability

  2009cited by this paper
• FRET-based in vitro assays for the analysis of SUMO protease activities.

  2009cited by this paper
• Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins.

  2008cited by this paper
• ICA512 signaling enhances pancreatic β-cell proliferation by regulating cyclins D through STATs

  2008cited by this paper
• SUMO under stress.

  2008cited by this paper
• Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

  2007cited by this paper
• SUMOylation regulates kainate-receptor-mediated synaptic transmission

  2007cited by this paper
• Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia

  2007cited by this paper
• SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5

  2007cited by this paper
• Concepts in sumoylation: a decade on

  2007cited by this paper
• Reduced Incretin Effect in Type 2 Diabetes

  2007cited by this paper
• Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

  2007cited by this paper
• Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes

  2006cited by this paper
• Regulation of protein phosphatase 1γ activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism

  2006cited by this paper
• Secretin receptor oligomers form intracellularly during maturation through receptor core domains.

  2006cited by this paper
• SUMO‐1 represses apoptosis signal‐regulating kinase 1 activation through physical interaction and not through covalent modification

  2005cited by this paper
• Sumoylation silences the plasma membrane leak K+ channel K2P1.

  2005cited by this paper
• A fluorescence resonance energy transfer-based assay to study SUMO modification in solution.

  2005cited by this paper
• Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line*[boxs]

  2005cited by this paper
• Quantitative SUMO-1 modification of a vaccinia virus protein is required for its specific localization and prevents its self-association.

  2005cited by this paper
• Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

  2005cited by this paper
• Biologic actions and therapeutic potential of the proglucagon-derived peptides

  2005cited by this paper
• Sumoylation increases HIF-1alpha stability and its transcriptional activity.

  2004cited by this paper
• Global shifts in protein sumoylation in response to electrophile and oxidative stress.

  2004cited by this paper
• SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2

  2004cited by this paper
• Sumoylation increases HIF-1α stability and its transcriptional activity

  2004cited by this paper
• Non-covalent interaction between nucleocapsid protein of Tula hantavirus and small ubiquitin-related modifier-1, SUMO-1.

  2003cited by this paper
• SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

  1998cited by this paper
• Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.

  1996cited by this paper
• Desensitization of glucagon‐like peptide 1 receptors in insulininsulinsecreting βTC3 cells: role of PKA‐independent mechanisms

  1996cited by this paper
• Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

  1987cited by this paper

• Signaling architecture of the glucagon-like peptide-1 receptor

  2026cites this paper
• Emerging Roles of Post-Translational Modifications in Metabolic Homeostasis and Type 2 Diabetes

  2025cites this paper
• Exploring potential targets for natural product therapy of DN: the role of SUMOylation

  2024cites this paper
• Post-Translational Modifications and Diabetes

  2024cites this paper
• Regulation of insulin secretion by the post-translational modifications

  2023cites this paper
• Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus.

  2022cites this paper
• Posttranslational modifications in diabetes: Mechanisms and functions

  2022cites this paper
• β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

  2021cites this paper
• Mechanisms controlling pancreatic islet cell function in insulin secretion

  2021cites this paper
• SUMOylation, a multifaceted regulatory mechanism in the pancreatic beta cells.

  2020cites this paper
• β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

  2020cites this paper
• Glucagon‐like peptide‐1 receptor undergoes importin‐α‐dependent nuclear localization in rat aortic smooth muscle cells

  2020cites this paper
• Protein SUMOylation regulates insulin secretion at multiple stages

  2019cites this paper
• The spatiotemporal control of signalling and trafficking of the GLP-1R

  2019cites this paper
• A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets

  2018cites this paper
• Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function

  2018cites this paper
• Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification

  2018cites this paper
• Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa

  2016cites this paper
• Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis

  2016cites this paper
• Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

  2016influential citation
• Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

  2015cites this paper
• Exercise-Induced Pancreatic Islet Adaptations in Health and Disease 19

  2015cites this paper
• Exercise Exercise -Induced Pancreatic Islet Pancreatic Islet Adaptations in Health and Disease

  2015cites this paper
• Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

  2015cites this paper
• Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins.

  2015cites this paper
• Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells

  2015cites this paper
• Targeting SUMOylation cascade for diabetes management.

  2014cites this paper
• SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

  2014cites this paper
• SUMO1 enhances cAMP‐dependent exocytosis and glucagon secretion from pancreatic α‐cells

  2014influential citation
• The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.

  2013cites this paper
• AMPK Is Involved in the Regulation of Incretin Receptors Expression in Pancreatic Islets under a Low Glucose Concentration

  2013cites this paper
• Modulation of pancreatic exocrine and endocrine secretion

  2013cites this paper
• DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

  2012influential citation