Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways

The ability of a cell to respond to a particular hormone depends on the presence of specific receptors for those hormones. Once the hormone has bound to its receptor, and following structural and biochemical modifications to the receptor, it separates from cytoplasmic chaperone proteins, thereby exposing the nuclear localization sequences that result in the activation of the receptor and initiation of the biological actions of the hormone on the target cell. In addition, recent work has demonstrated new pathways of steroid signaling through orphan and cell surface receptors that contribute to more rapid, “non-nuclear” or non-transcriptional effects of steroid hormones, often involving G-protein-mediated pathways. This review will summarize some of these studies for estrogens, androgens and progestins.

• Publication year

  2015

• Venue

  Unknown venue

• Publication date

  2015-06-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3934/MOLSCI.2015.3.294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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  2007cited by this paper
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