Autophosphorylation of the Mammalian Multifunctional Protein That Initiates de Novo Pyrimidine Biosynthesis*

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-07-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/JBC.M203512200PMID 11986331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1971cited by this paper
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  1970cited by this paper
• Modified methods for the determination of carbamyl aspartate.

  1969cited by this paper
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  1967cited by this paper
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  1967cited by this paper
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  1951cited by this paper

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