Oxidative Modification of Brain Proteins in Alzheimer's Disease: Perspective on Future Studies Based on Results of Redox Proteomics Studies

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2012-12-27

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3233/JAD-2012-129018PMID 22683528
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The oxidative stress hypothesis in Alzheimer's disease.

  2013cited by this paper
• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

  2013cited by this paper
• Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.

  2012cited by this paper
• Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

  2012cited by this paper
• Methionine-35 of Aβ(1–42): Importance for Oxidative Stress in Alzheimer Disease

  2011cited by this paper
• Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI

  2011cited by this paper
• Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress

  2010cited by this paper
• Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration

  2010cited by this paper
• Mitochondrial ATP‐Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

  2010cited by this paper
• Role of Oxidative Stress in the Progression of Alzheimer's Disease

  2010cited by this paper
• Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

  2010cited by this paper
• Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

  2010cited by this paper
• Examination of the current top candidate genes for AD in a genome-wide association study

  2010cited by this paper
• S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

  2009cited by this paper
• Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

  2009cited by this paper
• Redox proteomics identification of 4‐hydroxynonenal‐modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

  2009cited by this paper
• Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism

  2009cited by this paper
• Alzheimer's disease genetics current status and future perspectives.

  2009cited by this paper
• Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

  2009cited by this paper
• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes

  2009cited by this paper
• Genome-wide association studies in Alzheimer's disease.

  2009cited by this paper
• Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease.

  2009cited by this paper
• Role of glyceraldehyde-3-phosphate dehydrogenase in vesicular transport from Golgi apparatus to endoplasmic reticulum

  2008cited by this paper
• Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease.

  2008cited by this paper
• A possible link between astrocyte activation and tau nitration in Alzheimer's disease.

  2008cited by this paper
• Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.

  2008cited by this paper
• Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease.

  2008cited by this paper
• Oxidatively modified RNA in mild cognitive impairment.

  2008cited by this paper
• Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.

  2007cited by this paper
• Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

  2007influential reference
• Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.

  2007cited by this paper
• Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study

  2007influential reference
• Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment.

  2007cited by this paper
• Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Abeta(1-42).

  2006cited by this paper
• Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment.

  2006cited by this paper
• The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

  2006cited by this paper
• S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

  2006cited by this paper
• Protein carbonylation, cellular dysfunction, and disease progression

  2006cited by this paper
• Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease.

  2006cited by this paper
• REVIEW: Pin1 in Alzheimer's disease

  2006cited by this paper
• Oxidative Stress in Alzheimer's Disease Brain: New Insights from Redox Proteomics

  2006cited by this paper
• Redox proteomics: from protein modifications to cellular dysfunction and disease.

  2006cited by this paper
• Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.

  2006influential reference
• Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.

  2006influential reference
• Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment

  2006cited by this paper
• Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Aβ(1–42)☆

  2006cited by this paper
• Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain.

  2006cited by this paper
• Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases*

  2006cited by this paper
• Nitric Oxide–GAPDH–Siah: A Novel Cell Death Cascade

  2006cited by this paper
• Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. By Isabella Dalle‐Donne, Andrea Scaloni and A. Allan Butterfield (Eds.).

  2006cited by this paper
• Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics.

  2006cited by this paper
• Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.

  2005cited by this paper
• Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

  2005cited by this paper
• Neurotoxicity and oxidative stress in D1M-substituted Alzheimer's A beta(1-42): relevance to N-terminal methionine chemistry in small model peptides.

  2005cited by this paper
• The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity.

  2005cited by this paper
• Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

  2005cited by this paper
• Evidence of increased oxidative damage in subjects with mild cognitive impairment

  2005cited by this paper
• Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases*

  2004cited by this paper
• Alzheimer's amyloid β-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

  2004cited by this paper
• Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease.

  2004cited by this paper
• Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease

  2004cited by this paper
• Oxidatively Modified GST and MRP1 in Alzheimer’s Disease Brain: Implications for Accumulation of Reactive Lipid Peroxidation Products

  2004cited by this paper
• Lipid Peroxidation and Oxidative imbalance: Early functional events in Alzheimer's disease

  2004cited by this paper
• Enhanced brain levels of 8,12-iso-iPF2α-VI differentiate AD from frontotemporal dementia

  2003cited by this paper
• S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.

  2003cited by this paper
• Proteomic identification of nitrated proteins in Alzheimer's disease brain

  2003influential reference
• Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

  2002cited by this paper
• Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

  2002influential reference
• Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71

  2002cited by this paper
• The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

  2001cited by this paper
• Alzheimer's disease: genes, proteins, and therapy.

  2001cited by this paper
• Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide.

  2001cited by this paper
• Protein oxidation in the brain in Alzheimer's disease.

  2001cited by this paper
• In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

  1999cited by this paper
• The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

  1999cited by this paper
• Biomarkers of oxidative stress are significantly elevated in Down syndrome.

  1998cited by this paper
• Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

  1998cited by this paper
• Glutathione Conjugates Recognize the Rossmann Fold of Glyceraldehyde-3-phosphate Dehydrogenase*

  1997cited by this paper
• Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

  1997cited by this paper
• Oxidative stress hypothesis in Alzheimer's disease.

  1997cited by this paper
• Amyloid β-Protein and the Genetics of Alzheimer's Disease*

  1996cited by this paper
• Rat Brain Glyceraldehyde‐3‐Phosphate Dehydrogenase Interacts with the Recombinant Cytoplasmic Domain of Alzheimer's β‐Amyloid Precursor Protein

  1993cited by this paper

• Modified Sanjia Powder ameliorates cognitive impairment and exerts neuroprotective effects in 5 × FAD mice: insights from quantitative proteomics

  2026cites this paper
• miRNAs and Alzheimer’s Disease: Exploring the Role of Inflammation and Vitamin E in an Old-Age Population

  2023cites this paper
• The effect of antioxidants on the course and prevention of Alzheimer's disease on the example of vitamin E

  2023cites this paper
• Albumin: A Multi-talented Clinical and Pharmaceutical Player

  2022cites this paper
• Characterization of Male OF1cenp Mice with Age-Induced Cognitive Decline

  2022cites this paper
• S-Glutathionylation and S-Nitrosylation in Mitochondria: Focus on Homeostasis and Neurodegenerative Diseases

  2022cites this paper
• α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats

  2022cites this paper
• Emerging insights into the role of albumin with plasma exchange in Alzheimer's disease management.

  2021cites this paper
• Protective effect of EGb761 against Aβ1-42 -induced SHSY5Y cells injury and blood-brain barrier disruption via regulating Akt/Nrf2 signaling pathway

  2021cites this paper
• The level of carbonylation of plasma proteins and peripheral blood leukocytes in patients with different duration of Alzheimer’s disease

  2021cites this paper
• Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation

  2021cites this paper
• Class switching of Carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia.

  2020cites this paper
• Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities

  2020cites this paper
• Oxidative Stress and Alzheimer’s Disease

  2020cites this paper
• Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation

  2020cites this paper
• Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology

  2020cites this paper
• Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

  2019cites this paper
• Iron and oxidizing species in oxidative stress and Alzheimer's disease

  2019cites this paper
• Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease.

  2019cites this paper
• Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

  2019cites this paper
• Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats

  2018cites this paper
• APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress

  2018cites this paper
• Redox proteomics and amyloid β‐peptide: insights into Alzheimer disease

  2018cites this paper
• Amyloid Beta (Aβ) and Oxidative Stress:

  2018cites this paper
• Role of Mitochondria in Neurodegenerative Diseases: The Dark Side of the “Energy Factory”

  2018cites this paper
• Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer’s Disease Pathogenesis

  2017cites this paper
• Vitamin D and Neurological Diseases: An Endocrine View

  2017cites this paper
• Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

  2017cites this paper
• Neuroprotective Effect of Anthocyanin Extract from Lycium ruthenicum Murray in Aβ1–42-induced Rat Model of AD

  2017influential citation
• Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells.

  2017cites this paper
• Mitochondria in Alzheimer's Disease and Diabetes-Associated Neurodegeneration: License to Heal!

  2017cites this paper
• Energy and the Alzheimer brain

  2017cites this paper
• From redox proteomics to clinical practice : search for therapeutic targets

  2017cites this paper
• Estudio con criterios filogenéticos del potencial neuroprotector de líquenes parmeliáceos: mecanismos de acción de sus metabolitos secundarios

  2017cites this paper
• Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

  2017cites this paper
• Diversity of astroglial responses across human neurodegenerative disorders and brain aging

  2017cites this paper
• High salt diet impairs memory‐related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression

  2017cites this paper
• Changes of structure and IgE binding capacity of shrimp (Metapenaeus ensis) tropomyosin followed by acrolein treatment.

  2017cites this paper
• Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells.

  2017cites this paper
• Stress Response and Adaptation Mediated by Amino Acid Misincorporation during Protein Synthesis.

  2016cites this paper
• Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.

  2016cites this paper
• The association between PGC-1α and Alzheimer's disease

  2016cites this paper
• Clinical proteomics of enervated neurons

  2016cites this paper
• The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex

  2016cites this paper
• Perspective: A Critical Look at the Ancillary Age-Related Eye Disease Study 2: Nutrition and Cognitive Function Results in Older Individuals with Age-Related Macular Degeneration.

  2016cites this paper
• Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition.

  2016cites this paper
• Alzheimer's as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks.

  2016cites this paper
• Clinical proteomics of enervated

  2016cites this paper
• Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria

  2016cites this paper
• Metal Toxicity, Inflammation and Oxidative Stress

  2016cites this paper
• Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro.

  2015cites this paper
• Combination of Procyanidins Extracted from Lotus Seedpod and N-acetyl Cysteine Ameliorates Scopolamine-induced Memory Impairment in Mice

  2015cites this paper
• Orientin alleviates cognitive deficits and oxidative stress in Aβ1-42-induced mouse model of Alzheimer's disease.

  2015cites this paper
• Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice.

  2015cites this paper
• Membrane protein oxidation determines neuronal degeneration

  2015cites this paper
• Vitamin D deficiency and Alzheimer disease: Common links.

  2015cites this paper
• Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage.

  2015cites this paper
• Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease

  2015cites this paper
• Oxidative modification of glyceraldehyde-3-phosphate dehydrogenase influences its interaction with endogenous neuroprotector isatin

  2015cites this paper
• Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide.

  2014cites this paper
• Norepinephrine provides short-term neuroprotection against Aβ1-42 by reducing oxidative stress independent of Nrf2 activation.

  2014cites this paper
• Losartan-Induced Hypotension Leads to Tau Hyperphosphorylation and Memory Deficit

  2014cites this paper
• Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice.

  2014cites this paper
• The Emerging Role of Glutathione in Alzheimer's Disease

  2014cites this paper
• Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.

  2014cites this paper
• Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.

  2014cites this paper
• Antioxidative defense mechanisms in the aging brain

  2014cites this paper
• Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

  2014cites this paper
• Mechanism of oxidative inactivation of human presequence protease (hPreP) by hydrogen peroxide

  2014cites this paper
• Abeta, oxidative stress in Alzheimer disease: evidence based on proteomics studies.

  2014cites this paper
• Crocetin Prevents Amyloid β 1-42 -Induced Cell Death in Murine Hippocampal Cells

  2014cites this paper
• Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.

  2014cites this paper
• Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard.

  2014cites this paper
• Pathophysiology of tobacco smoke exposure: recent insights from comparative and redox proteomics.

  2014cites this paper
• Redox proteomics and the dynamic molecular landscape of the aging brain.

  2014cites this paper
• Deciphering the human brain proteome: characterization of the anterior temporal lobe and corpus callosum as part of the Chromosome 15-centric Human Proteome Project.

  2014cites this paper
• Ac-cel, a Novel Antioxidant, Protects Against Hydrogen Peroxide-induced Injury in PC12 Cells via Attenuation of Mitochondrial Dysfunction

  2013cites this paper
• Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1

  2013cites this paper
• Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N‐acetyl‐L‐cysteine

  2013cites this paper
• Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

  2013cites this paper
• Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation.

  2013cites this paper
• Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death☆

  2013cites this paper
• A high-salt diet further impairs age-associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway rats.

  2013cites this paper
• Redox imbalance and oxidative modifications of macromolecules in brain during aging and neurodegenerative diseases

  2013cites this paper
• S100b protects IMR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression

  2013cites this paper
• Curcumin-Mediated Neuroprotection Against Amyloid-β-Induced Mitochondrial Dysfunction Involves the Inhibition of GSK-3β

  2012cites this paper
• Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases.

  2012cites this paper