Molecular characterization of E587 antigen: An axonal recognition molecule expressed in the goldfish central nervous system

The E587 antigen (Ag) is a 200‐Kd membrane glycoprotein originally identified by a monoclonal antibody on new and regenerating retinal ganglion cell axons in the adult goldfish. We report the isolation of cDNAs encoding the E587 Ag and identify it as a member of the L1 family of cell adhesion molecules (CAMs). The predicted amino acid sequence of E587 Ag shows an approximately equal identity (40%) to mouse L1, chick neuron‐glia CAM, and chick neuron‐glia‐related CAM. Although the overall similarity is low, there is a high conservation of structural domains and specific sequence motifs.

• Publication year

  1997

• Venue

  The Journal of comparative neurology

• Publication date

  1997-01-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/(SICI)1096-9861(19970113)377:2<286::AID-CNE9>3.0.CO;2-#PMID 8986886
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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