Effect of spatial gradient in fluid shear stress on morphological changes in endothelial cells in response to flow.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2010-04-30

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1016/j.bbrc.2010.04.002PMID 20371223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MOLECULAR ALTERATIONS ASSOCIATED WITH ANEURYSMAL REMODELING ARE LOCALIZED IN THE HIGH HEMODYNAMIC STRESS REGION OF A CREATED CAROTID BIFURCATION

  2009cited by this paper
• Morphological Responses of Vascular Endothelial Cells Induced by Local Stretch Transmitted Through Intercellular Junctions

  2009cited by this paper
• Endothelial Cell Layer Subjected to Impinging Flow Mimicking the Apex of an Arterial Bifurcation

  2008cited by this paper
• Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow.

  2008cited by this paper
• Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

  2007cited by this paper
• The shear stress of it all: the cell membrane and mechanochemical transduction

  2007cited by this paper
• Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression.

  2007cited by this paper
• Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress.

  2007cited by this paper
• Effect of flow direction on the morphological responses of cultured bovine aortic endothelial cells

  2006cited by this paper
• Effect of Fluid Shear Stress on Migration of Vascular Smooth Muscle Cells in Cocultured Model

  2006cited by this paper
• Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin.

  2005cited by this paper
• A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

  2005cited by this paper
• Studies of Blood Flow in Arterial Bifurcations; from Influence of Hemodynamics on Endothelial Cell Response to Vessel Wall Mechanics

  2004cited by this paper
• Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases

  2003cited by this paper
• Effect of magnetic field on nitric oxide synthesis of cultured endothelial cells

  2002cited by this paper
• Interplay between integrins and FLK-1 in shear stress-induced signaling.

  2002cited by this paper
• Analysis of the effect of disturbed flow on monocytic adhesion to endothelial cells.

  2002cited by this paper
• Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

  2002cited by this paper
• Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering.

  2000cited by this paper
• P2X4 receptors mediate ATP-induced calcium influx in human vascular endothelial cells

  2000cited by this paper
• The protein tyrosine phosphatase Shp-2 regulates RhoA activity.

  2000cited by this paper
• P2X(4) receptors mediate ATP-induced calcium influx in human vascular endothelial cells.

  2000cited by this paper
• Hemodynamic shear stress and its role in atherosclerosis.

  1999cited by this paper
• Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro.

  1999cited by this paper
• Flow-dependent regulation of gene expression in vascular endothelial cells.

  1996cited by this paper
• Flow-mediated endothelial mechanotransduction.

  1995cited by this paper
• Shear stress modulates endothelial cell morphology and F‐actin organization through the regulation of focal adhesion‐associated proteins

  1995cited by this paper
• Intracellular calcium response to directly applied mechanical shearing force in cultured vascular endothelial cells

  1994cited by this paper
• Morphological responses of single endothelial cells exposed to physiological levels of fluid shear stress.

  1993cited by this paper
• An apparatus to study the response of cultured endothelium to shear stress.

  1986cited by this paper
• The dynamic response of vascular endothelial cells to fluid shear stress.

  1981cited by this paper

• Cyclic stretch induces autophagy-mediated focal adhesion remodeling and activates mitochondria

  2026cites this paper
• Impinging flow regulates endothelial cell injury via HMGB1-mediated ferroptosis to promote intracranial aneurysm formation and progression.

  2026cites this paper
• Artificial Intelligence-Aided Microfluidic Cell Culture Systems

  2025cites this paper
• Role of endothelial shear stress metrics in the development and eruption of coronary calcified nodules.

  2025cites this paper
• PLATINUM –COATED TITANIUM NANOTUBES -ENHANCING THE CORROSION RESISTANCE AND BIOMINERALIZATION

  2025cites this paper
• Vascular Microphysiological System for Investigating Endothelial Barrier Function During Organ Preservation and Reperfusion

  2025cites this paper
• Use microfluidics to study cell migration in response to fluid shear stress gradients

  2024cites this paper
• A synergistic effect of wall shear stress and impinging jet velocity on vascular endothelial cell morphology and actin cytoskeleton

  2024cites this paper
• Socio-demographic inequalities in the impacts of extreme temperatures on population mobility

  2024cites this paper
• Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell.

  2024cites this paper
• Disruptive effect of impinging jet flow environment on the integrity of endothelial monolayer

  2023cites this paper
• HMGB1 Induced Oxidative Stress and Inflammation in Endothelial Cells Exposed to Impinging Flow

  2023cites this paper
• High Wall Shear Incites Cerebral Aneurysm Formation and Low Wall Shear Stress Propagates Cerebral Aneurysm Growth

  2023cites this paper
• Irregular anatomical features can alter hemodynamics in Takayasu arteritis

  2023cites this paper
• Microvasculature‐on‐a‐Post Chip That Recapitulates Prothrombotic Vascular Geometries and 3D Flow Disturbance

  2023cites this paper
• The role of endothelial shear stress, shear stress gradient, and plaque topography in plaque erosion.

  2023cites this paper
• Experimental and mouse-specific computational models of the Fbln4SMKO mouse to identify potential biomarkers for ascending thoracic aortic aneurysm

  2022cites this paper
• Cumulative time of cigarette smoking is associated with a greater risk of aneurysmal subarachnoid haemorrhage and younger age at presentation: A nationwide observation study.

  2022cites this paper
• Organ-on-a-chip: A new tool for in vitro research.

  2022cites this paper
• The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

  2022cites this paper
• In vitro fluidic systems: Applying shear stress on endothelial cells

  2022cites this paper
• In Vitro Flow Chamber Design for the Study of Endothelial Cell (patho)physiology.

  2021cites this paper
• Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel 3D tissue model for bacterial infection and immunity

  2021cites this paper
• Gene Polymorphisms Increasing the Riskof Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II)

  2021cites this paper
• Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips.

  2021cites this paper
• Hemodynamics in the circle of Willis and prognostic factors in subarachnoid hemorrhage

  2021cites this paper
• Shedding the Light on the Natural History of Intracranial Aneurysms: An Updated Overview

  2021cites this paper
• Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

  2021cites this paper
• Recapitulation of human embryonic heart beating to promote differentiation of hepatic endoderm to hepatoblasts

  2020cites this paper
• The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton.

  2020cites this paper
• Epigenetic response of endothelial cells to different wall shear stress magnitudes: A report of new mechano‐miRNAs

  2020cites this paper
• Deciphering ascending thoracic aortic aneurysm hemodynamics in relation to biomechanical properties.

  2020cites this paper
• Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

  2020cites this paper
• High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion.

  2020cites this paper
• Endothelial Cell Polarization and Orientation to Flow in a Novel Microfluidic Multimodal Shear Stress Generator

  2020cites this paper
• Scleroderma's possible dual role in the pathophysiology of intracranial aneurysms:Case report and literature review.

  2020cites this paper
• In vitro, primarily microfluidic models for atherosclerosis

  2020cites this paper
• Endothelial dysfunction in cerebral aneurysms

  2019cites this paper
• Atorvastatin Protects Against Cerebral Aneurysmal Degenerative Pathology by Promoting Endothelial Progenitor Cells (EPC) Mobilization and Attenuating Vascular Deterioration in a Rat Model

  2019cites this paper
• Is there a causal relationship between obstructive sleep apnea and the pathophysiology of intracranial aneurysm?

  2019cites this paper
• Endothelial cell distributions and migration under conditions of flow shear stress around a stent wire

  2019cites this paper
• Cell Migration in Shear Field: Comparative Study between MC3T3-E1 and 3T3-L1

  2019cites this paper
• Titanium Dioxide Nanotube Arrays for Biomedical Implant Materials and Nanomedicine Applications

  2018cites this paper
• Multilayer flow modulator enhances vital organ perfusion in patients with type B aortic dissection.

  2018cites this paper
• Computing of Low Shear Stress-Driven Endothelial Gene Network Involved in Early Stages of Atherosclerotic Process

  2018cites this paper
• Three-dimensional advance dynamic culture system promotes microvessel development from cultured endothelial cells in vitro

  2017cites this paper
• Fluid shear stress combined with shear stress spatial gradients regulates vascular endothelial morphology.

  2017cites this paper
• The role of evolution in the genetic susceptibility of intracranial aneurysm

  2017cites this paper
• Influence of shear stress on phenotype and MMP production of smooth muscle cells in a co-culture model

  2017cites this paper
• Bioreactors for Cell Culture Systems and Organ Bioengineering

  2017cites this paper
• Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions

  2016cites this paper
• Relative contribution of physiological hydrostatic pressure and fluid shear stress to endothelial monolayer integrity

  2016cites this paper
• Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients

  2016cites this paper
• Relative contribution of physiological hydrostatic pressure and fluid shear stress to endothelial monolayer integrity

  2016cites this paper
• Development of Microfluidic Systems for Fabricating Cellular Multilayers

  2016cites this paper
• Three-dimensional imaging of biological cells with picosecond ultrasonics

  2015cites this paper
• Correlation of mechanical stresses with arterial disease frequency in animal models

  2015cites this paper
• Formation of contractile networks and fibers in the medial cell cortex through myosin‐II turnover, contraction, and stress‐stabilization

  2015cites this paper
• Device-based in vitro techniques for mechanical stimulation of vascular cells: a review.

  2015cites this paper
• Development of an image processing method for automated, non-invasive and scale-independent monitoring of adherent cell cultures

  2015cites this paper
• Quantitative analysis of stenting effects on cellular response

  2015cites this paper
• Responses of Living Cells to Hydrodynamic Stimuli Due to Fluid Flow

  2014cites this paper
• Efficacy of Chlorine-based, Enzymatic and Combined Chlorine-enzyme Treatments on Biofilm Removal

  2014cites this paper
• A Comparative Review of the Hemodynamics and Pathogenesis of Cerebral and Abdominal Aortic Aneurysms: Lessons to Learn From Each Other

  2014cites this paper
• Quantitative imaging of sex and age differences in human cortical bone osteocyte lacunae

  2014cites this paper
• Predicting Outcome of Aortic Dissection with Patent False Lumen by Computational Flow Analysis

  2014cites this paper
• Predicting Outcome of Aortic Dissection with Patent False Lumen by Computational Flow Analysis

  2014cites this paper
• Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow.

  2014cites this paper
• Regional variation of wall shear stress in ascending thoracic aortic aneurysms

  2014cites this paper
• The early mouse 3D osteocyte network in the presence and absence of mechanical loading.

  2013cites this paper
• Engineering Parameters in Bioreactor's Design: A Critical Aspect in Tissue Engineering

  2013cites this paper
• Development of Novel Flow Chamber to Study Endothelial Cell Morphology: Effects of Shear Flow with Uniform Spatial Gradient on Distribution of Focal Adhesion*

  2013cites this paper
• The effect of glucose concentration and shaking conditions on Escherichia coli biofilm formation in microtiter plates

  2013cites this paper
• A quantitative analysis of hemodynamic forces on cellular response

  2013influential citation
• Analysis of a high‐throughput cone‐and‐plate apparatus for the application of defined spatiotemporal flow to cultured cells

  2013cites this paper
• Automated Method for the Rapid and Precise Estimation of Adherent Cell Culture Characteristics from Phase Contrast Microscopy Images

  2013cites this paper
• Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension

  2013cites this paper
• Shear- vs. nanotopography-guided control of growth of endothelial cells on RGD-nanoparticle-nanowell arrays

  2013cites this paper
• Fluid Flow Induced Shear Stress Affects Cell Growth and Total Flavone Production by Phellinus igniarius in Stirred-Tank Bioreactor

  2012cites this paper
• Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture

  2012cites this paper
• High Wall Shear Stress and Spatial Gradients in Vascular Pathology: A Review

  2012cites this paper
• Examining a Role for Planar Cell Polarity Signaling in Endothelial Cell Alignment and Organization

  2012influential citation
• Engineering Airway Epithelium

  2012cites this paper
• Biology of Intracranial Aneurysms: Role of Inflammation

  2012cites this paper
• Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review

  2011cites this paper
• Novel methodologies for investigating the pathophysiology of cerebral aneurysms

  2011cites this paper
• Effect of Initial Orientation of Vascular Endothelial Cells on Activation of RhoGTPases Induced by Fluid Shear Stress

  2011cites this paper
• High Fluid Shear Stress and Spatial Shear Stress Gradients Affect Endothelial Proliferation, Survival, and Alignment

  2011cites this paper