Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Organic Chemistry

• Publication date

  2001-05-04

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/JO010153KPMID 11325300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Makaluvamines vary in ability to induce dose-dependent DNA cleavage via topoisomerase II interaction.

  1999cited by this paper
• A screening method for isolating DNA repair-deficient mutants of CHO cells

  1980cited by this paper

• Greener synthesis of Pyrroloacridine-1(2H)-one and 1,8-Dioxodecahydroacridine derivatives: Ascorbic acid mediated OrganocatalyticApproach

  2025cites this paper
• Bioinspired Syntheses of the Marine Pyridoacridine Alkaloids 2-Bromo and 3-Bromodeoxyamphimedine and Structure Correction of 2-Bromoamphimedine.

  2025cites this paper
• Marine natural compounds as potential CBP bromodomain inhibitors for treating cancer: an in-silico approach using molecular docking, ADMET, molecular dynamics simulations and MM-PBSA binding free energy calculations

  2024cites this paper
• Marine pyridoacridine, pyridoacridone and pyrroloacridine alkaloids.

  2023cites this paper
• Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library

  2023cites this paper
• Toward the Total Synthesis of Alpkinidine: Michael Addition to Isoquinolinetrione CE Ring-System Synthons

  2022cites this paper
• Toward the Total Synthesis of Alpkinidine: Synthesis of Haloquinone CE Ring System Synthons and Attempted Nucleophilic Bisannulation

  2022cites this paper
• Biological Activity of Naturally Derived Naphthyridines

  2021cites this paper
• Gold-catalyzed formation of aryl-fused pyrazolooxazepines via intramolecular regioselective 7-exo-dig cyclization.

  2019cites this paper
• Chemoselective synthesis of drug-like pyrrolo[2,3,4-kl]acridin-1-one using polyoxometalate@lanthanoid catalyst

  2019cites this paper
• Isolation, Synthesis and Medicinal Significance of Marine Pyridoacridine Alkaloids

  2019cites this paper
• Pyridoacridines in the 21st Century

  2019cites this paper
• Revisiting of Boron Sulfonic Acid Applications in Organic Synthesis: Mini-Review

  2019cites this paper
• Eco-Friendly and Facile Approach Toward a One-Pot Synthesis of 2-Arylpyrrolo[2,3,4-kl]acridin-1(2H)-ones Catalyzed by Acetic Acid Under Solvent-Free Conditions

  2018cites this paper
• Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.

  2017cites this paper
• Gold-catalyzed intramolecular cyclization/condensation sequence: synthesis of 1,2-dihydro[c][2,7]naphthyridines.

  2017cites this paper
• Bioactive Alkaloids from Marine Sponges

  2017cites this paper
• Struktur und Biosynthese der Isatropolone, bioaktiver und Amin-reaktiver fluoreszierender Naturstoffe aus Streptomyces Gö66

  2017cites this paper
• Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

  2016cites this paper
• Bioinspired Syntheses of the Pyridoacridine Marine Alkaloids Demethyldeoxyamphimedine, Deoxyamphimedine, and Amphimedine.

  2016cites this paper
• Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities

  2016cites this paper
• Pyridoacridine alkaloids from deep-water marine organisms: Structural elucidation

  2016cites this paper
• Bioactive Alkaloids from Marine Sponges

  2016cites this paper
• Eco-Friendly and Facile Approach Toward a One-Pot Synthesis of 2-Arylpyrrolo[2,3,4-kl]acridin-1(2H)-ones Catalyzed by Acetic Acid Under Solvent-Free Conditions

  2016cites this paper
• Alkaloids: A Source of Anticancer Agents from Nature

  2015cites this paper
• Simultaneous sonication assistance for the synthesis of pyrroloacridinones and its efficient catalyst HBF4 supported on uniform spherical silica nanoparticles.

  2015cites this paper
• One-pot, three-component reaction of dimedone, amines, and isatin in the presence of tris(hydrogensulfato) boron: synthesis of pyrroloacridine derivatives

  2015cites this paper
• Pyridoacridine Alkaloids from Marine Origin: Sources and Anticancer Activity

  2015cites this paper
• Covalently anchored carboxylic acid on uniform spherical silica nanoparticles with narrow slit like mesopores for the synthesis of pyrroloacridinones: CuI-catalyzed further C(sp3)–H oxyfunctionalization for CO formation

  2014cites this paper
• Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

  2014cites this paper
• Porifera (Sponges)–5

  2014cites this paper
• An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

  2014cites this paper
• Porifera (Sponges)–3

  2014cites this paper
• Tandem synthesis of pyrroloacridones via [3 + 2] alkyne annulation/ring-opening with concomitant intramolecular aldol condensation.

  2013cites this paper
• An unexpected multicomponent reaction leading to 2-arylpyrrolo[2,3,4-kl]acridin-1(2H)-ones

  2012cites this paper
• Assembly of pentacyclic pyrido[4,3,2-mn]acridin-8-ones via a domino reaction initiated by Au(I)-catalyzed 6-endo-dig cycloisomerization of N-propargylaminoquinones

  2012cites this paper
• Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay

  2010cites this paper
• A short route to the synthesis of pyrroloacridines via Ullmann–Goldberg condensation

  2010cites this paper
• Chemical and Biological Aspects of Marine Sponges of the Genus Xestospongia

  2010cites this paper
• Deoxyamphimedine, a Pyridoacridine Alkaloid, Damages DNA via the Production of Reactive Oxygen Species

  2009cites this paper
• Aaptamine and related products. Their isolation, chemical syntheses, and biological activity.

  2009cites this paper
• Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.

  2007cites this paper
• Synthesis of new flat polyheterocyclic systems potential DNA intercalating agents diazines part 47

  2006cites this paper
• Azinyl sulfides. LXXXI.(1)14-Phenyl-7-thiapyrano[2,3-c;6,5-c']diquinoline-14-carbonitrile.

  2005cites this paper
• SYNTHESE D'HETEROCYCLES AZOTES DERIVES D'ACRIDINE ET ETUDE DE LEUR INTERACTION AVEC L'ADN

  2005cites this paper
• Novel antitumor agents: marine sponge alkaloids, their synthetic analogs and derivatives.

  2005cites this paper
• Facile and Simple Route to the Synthesis of Condensed Acridine Systems

  2005cites this paper
• AK37: the first pyridoacridine described capable of stabilizing the topoisomerase I cleavable complex

  2004cites this paper
• Biological activities of pyridoacridines.

  2004cites this paper
• Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents

  2003cites this paper
• Novel alkaloids of the aaptamine class from an Indonesian marine sponge of the genus Xestospongia

  2003cites this paper
• Marine natural products.

  2003cites this paper
• Anti-Cancer Metabolites from Marine Sponges

  2002cites this paper
• Structures and cytotoxic properties of sponge-derived bisannulated acridines.

  2002cites this paper
• The pyridoacridine family tree: a useful scheme for designing synthesis and predicting undiscovered natural products.

  2002cites this paper
• Sebastianines A and B, novel biologically active pyridoacridine alkaloids from the Brazilian ascidian Cystodytes dellechiajei.

  2002cites this paper
• Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine.

  2002cites this paper
• Deoxyamphimedine, a New Pyridoacridine Alkaloid from Two Tropical Xestospongia Sponges

  2001cites this paper