Inhibition of HIV protease activity by heterodimer formation.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Biochemistry

• Publication date

  1991-01-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00215A016PMID 1988010
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Electronic energy transfer and fluorescence quenching in the active sites of mercuric reductase.

  1991cited by this paper
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  1990cited by this paper
• Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

  1990cited by this paper
• Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro.

  1990cited by this paper
• Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

  1990cited by this paper
• A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation.

  1990cited by this paper
• Substrate analogue inhibition and active site titration of purified recombinant HIV-1 protease.

  1990influential reference
• Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease.

  1990influential reference
• Protein and pharmaceutical engineering : proceedings of an Upjohn-UCLA Symposium, held at Park City, Utah January 17-22, 1989

  1990cited by this paper
• Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

  1989cited by this paper
• Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

  1989cited by this paper
• Crystal structure of a retroviral protease proves relationship to aspartic protease family

  1989cited by this paper
• Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease.

  1989cited by this paper
• Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein

  1989cited by this paper
• Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.

  1989cited by this paper
• X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes

  1989cited by this paper
• Molecular modeling of the HIV-1 protease and its substrate binding site.

  1989cited by this paper
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  1989cited by this paper
• Purification and structural characterization of the putative gag-pol protease of human immunodeficiency virus

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• Active human immunodeficiency virus protease is required for viral infectivity.

  1988cited by this paper
• Formation of heterodimers between wild type and mutant trp aporepressor polypeptides of Escherichia coli

  1988cited by this paper
• In vivo and in vitro autoprocessing of human immunodeficiency virus protease expressed in Escherichia coli.

  1988cited by this paper
• Expression and processing of biologically active fibroblast growth factors in the yeast Saccharomyces cerevisiae.

  1988influential reference
• Genome organization and transactivation of the human immunodeficiency virus type 2

  1987cited by this paper
• A structural model for the retroviral proteases

  1987cited by this paper
• Functional inactivation of genes by dominant negative mutations

  1987cited by this paper
• Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.

  1987cited by this paper
• Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus

  1986cited by this paper
• Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides

  1986cited by this paper
• Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2

  1986cited by this paper
• Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).

  1985cited by this paper
• Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

  1984cited by this paper
• The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of Saccharomyces cerevisiae is responsible for curing and high copy number

  1983cited by this paper

• Phenanthridine derivatives as potential HIV-1 protease inhibitors.

  2020cites this paper
• Applications of 3-aminolactams: design, synthesis, and biological evaluation of a library of potential dimerisation inhibitors of HIV1-protease.

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  2012cites this paper
• Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy.

  2011cites this paper
• Using specificity to strategically target proteases.

  2009cites this paper
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  2008cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
• The dimerization domain of the HIV‐1 capsid protein binds a capsid protein‐derived peptide: A biophysical characterization

  2004cites this paper
• Design and synthesis of constrained dipeptide units for use as �-sheet promoters

  2003cites this paper
• Thermodynamic Dissection of a Low Affinity Protein-Protein Interface Involved in Human Immunodeficiency Virus Assembly*

  2003cites this paper
• Mutagenesis of the dimer interface residues of tethered and untethered HIV-1 protease result in differential activity and suggest multiple mechanisms of compensation.

  2003cites this paper
• Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region.

  2002cites this paper
• Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules.

  2002cites this paper
• HIV-1 protease: characterization of a catalytically competent enzyme-substrate intermediate.

  2002cites this paper
• Computational study of protein specificity: The molecular basis of HIV-1 protease drug resistance

  2001cites this paper
• Importance of the N Terminus of Rous Sarcoma Virus Protease for Structure and Enzymatic Function

  2001cites this paper
• Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody.

  2001cites this paper
• Effectors of HIV-1 protease peptidolytic activity.

  2001cites this paper
• Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates.

  2001cites this paper
• Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants.

  2000cites this paper
• Macromolecular Inhibitors of HIV-1 Protease

  2000cites this paper
• Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues.

  2000cites this paper
• Approaches to the design of effective HIV-1 protease inhibitors.

  2000cites this paper
• Inhibition of the HIV‐1 and HIV‐2 proteases by a monoclonal antibody

  1999cites this paper
• Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization.

  1999cites this paper
• Engineering catalytically defective forms of HIV protease to modulate its activity.

  1998cites this paper
• Effect of HIV constructs containing protease‐reverse transcriptase fusion proteins on viral replication

  1998cites this paper
• Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins.

  1998cites this paper
• Inhibiting the assembly of protein-protein interfaces.

  1998cites this paper
• Mouse monoclonal antibodies directed against the HTLV-I protease recognize epitopes internal to the dimer.

  1997cites this paper
• HIV-1 Protease and its Inhibitors

  1997cites this paper
• Therapeutic effect of Gag-nuclease fusion protein on retrovirus-infected cell cultures

  1996cites this paper
• Computational biochemistry of antibodies and T-cell receptors.

  1996cites this paper
• The inhibition of human immunodeficiency virus proteases by 'interface peptides'.

  1996cites this paper
• Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles

  1996cites this paper
• Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines

  1996cites this paper
• Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.

  1995cites this paper
• Expression and purification of active form of HIV-1 protease from E.coli.

  1995cites this paper
• Current advances in the X-ray crystallography of proteins

  1995cites this paper
• Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1.

  1994cites this paper
• The subunit interfaces of oligomeric enzymes are conserved to a similar extent to the overall protein sequences

  1994cites this paper
• Interactions of substrates and inhibitors with a family of tethered HIV-1 and HIV-2 homo- and heterodimeric proteinases.

  1994cites this paper
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  1994cites this paper
• Expression and Purification of HIV-1 Protease Utilizing a Maltose Binding Protein

  1994cites this paper
• Dissociation and association of the HIV-1 protease dimer subunits: equilibria and rates.

  1994cites this paper
• Present status and future prospects for HIV therapies.

  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1991cites this paper
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  1991cites this paper
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  1991cites this paper
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  1991cites this paper
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  1991cites this paper