Preparation and Antitumor Activity of a Polymeric Derivative of Methotrexate

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of the Medical Sciences

• Publication date

  2012-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/MAJ.0b013e3182541ad6PMID 22885620
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference
• Activation and cytotoxicity of 2-alpha-aminoacyl prodrugs of methotrexate.

  1995cited by this paper
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  1995cited by this paper
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