Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Neuroscience

• Publication date

  2017-01-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuroscience.2016.11.007PMID 27845178
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015influential reference
• β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells.

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  2012influential reference
• Malate-aspartate shuttle and exogenous NADH/cytochrome c electron transport pathway as two independent cytosolic reducing equivalent transfer systems.

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  2009influential reference
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• Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability

  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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• Pyruvate recycling in cultured neurons from cerebellum

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• Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.

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  2006cited by this paper
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• Molecular basis of human glutamate dehydrogenase regulation under changing energy demands

  2005cited by this paper
• Glycolysis and Glutamate Accumulation into Synaptic Vesicles

  2003influential reference
• Ischemic Cell Death: Dynamics of Delayed Secondary Energy Failure During Reperfusion Following Focal Ischemia

  2002cited by this paper
• Metabolic Compartmentation in Cortical Synaptosomes: Influence of Glucose and Preferential Incorporation of Endogenous Glutamate into GABA

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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Glutamate in synaptic terminals is reduced by lack of glucose but not hypoxia in rat hippocampal slices.

  1999cited by this paper
• Origins of the Extracellular Glutamate Released During Total Metabolic Blockade in the Immature Retina

  1998cited by this paper
• Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.

  1998cited by this paper
• Glutamate transport and metabolism in astrocytes.

  1997influential reference
• New insights into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes.

  1996influential reference
• The human glutamate dehydrogenase gene family: gene organization and structural characterization.

  1993cited by this paper
• Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: a semiquantitative electron microscopic study in rat hippocampus.

  1991cited by this paper
• Activation of Glutamate Dehydrogenase by Leucine and Its Nonmetabolizable Analogue in Rat Brain Synaptosomes

  1990cited by this paper
• Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: implications for neuron-glia interactions in glutamate transmission

  1987cited by this paper
• High affinity Ca2+-stimulated Mg2+-dependent ATPase in rat brain synaptosomes, synaptic membranes, and microsomes.

  1983cited by this paper
• Metabolic Fate of 14C‐Labeled Glutamate in Astrocytes in Primary Cultures

  1982influential reference

• A non‐redundant role of EAAT3 for ATP synthesis mediated by GDH in dopaminergic neuronal cells: a new avenue for glutamate metabolism and protection in Parkinson's disease

  2025influential citation
• Squalene, a bioactive compound in Ficus exasperata (VAHL) leaf, binds gamma-glutamyl transferase (GGT) to ameliorate alcohol-induced tissue damage

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  2025cites this paper
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  2024cites this paper
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• Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning

  2023cites this paper
• mTOR/α-ketoglutarate signaling: impact on brain cell homeostasis under ischemic conditions

  2023cites this paper
• Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease.

  2023cites this paper
• β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes

  2023cites this paper
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• Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures

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  2023cites this paper
• mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection.

  2022cites this paper
• Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model

  2022cites this paper
• Mitochondrial Disorders in Stroke and Chronic Brain Ischemia

  2021cites this paper
• Glutamate Metabolism in Mitochondria is Closely Related to Alzheimer’s Disease

  2021cites this paper
• Glutamate-induced modulation in energy metabolism contributes to protection of rat cortical slices against ischemia-induced damage.

  2020cites this paper
• β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol

  2020cites this paper
• Pharmacological effects and involved mechanisms of muscone.

  2020cites this paper
• Intracellular Calcium and Ischemic Damage: Dual Role of the Na+/Ca2+ Exchanger

  2020cites this paper
• Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

  2020cites this paper
• Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions

  2020cites this paper
• NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival.

  2020cites this paper
• Gateways for Glutamate Neuroprotection in Parkinson’s Disease (PD): Essential Role of EAAT3 and NCX1 Revealed in an In Vitro Model of PD

  2020cites this paper
• The dual face of glutamate: from a neurotoxin to a potential survival factor—metabolic implications in health and disease

  2019cites this paper
• Allosteric regulation of glutamate dehydrogenase deamination activity

  2019influential citation
• Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson’s Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways

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• Mitochondrial disorders in neuromuscular pathology

  2019cites this paper
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  2018cites this paper
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  2018influential citation
• Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes

  2018cites this paper
• Glutamate metabolism in cerebral mitochondria after ischemia and post‐ischemic recovery during aging: relationships with brain energy metabolism

  2018cites this paper
• Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury.

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• Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans

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• Mild metabolic perturbations alter succinylation of mitochondrial proteins

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