Cardiovascular , Pulmonary and Renal Pathology Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation.

  2007cited by this paper
• Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

  2007cited by this paper
• Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells.

  2007cited by this paper
• Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

  2007cited by this paper
• The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

  2007cited by this paper
• Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.

  2007cited by this paper
• Oxidative stress in pathogenesis of chronic obstructive pulmonary disease

  2007cited by this paper
• Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice.

  2006cited by this paper
• Toll-like receptor 4 deficiency causes pulmonary emphysema.

  2006cited by this paper
• Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

  2006cited by this paper
• Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages

  2006cited by this paper
• Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

  2006cited by this paper
• State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease.

  2006cited by this paper
• Cell death, remodeling, and repair in chronic obstructive pulmonary disease?

  2006cited by this paper
• Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages

  2006cited by this paper
• Rac1 GTPase Regulates Cell Genomic Stability and Senescence*

  2006cited by this paper
• Endotoxin Induces Toll-Like Receptor 4 Expression in Vascular Smooth Muscle Cells via NADPH Oxidase Activation and Mitogen-Activated Protein Kinase Signaling Pathways

  2006cited by this paper
• Oxidative stress and redox regulation of lung inflammation in COPD

  2006cited by this paper
• Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.

  2006cited by this paper
• Murine TLR4 Is Implicated in Cigarette Smoke-Induced Pulmonary Inflammation

  2006cited by this paper
• Cigarette smoke-induced emphysema: A role for the B cell?

  2006cited by this paper
• Role of CXCR2 in cigarette smoke-induced lung inflammation.

  2005cited by this paper
• Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization1

  2005cited by this paper
• Correlation of lung surface area to apoptosis and proliferation in human emphysema

  2005cited by this paper
• STRUCTURAL EMPHYSEMA DOES NOT CORRELATE WITH LUNG COMPLIANCE: LESSONS FROM THE MOUSE SMOKING MODEL

  2005cited by this paper
• Matrix metalloproteinases in asthma and COPD.

  2005cited by this paper
• cis-Acting Element-specific Transcriptional Activity of Differentially Phosphorylated Nuclear Factor-κB*

  2005cited by this paper
• Chronic granulomatous disease: from genetic defect to clinical presentation.

  2005cited by this paper
• NF-kappaB RelA phosphorylation regulates RelA acetylation.

  2005cited by this paper
• NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages*

  2005cited by this paper
• Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

  2005cited by this paper
• Stable Compounds of Cigarette Smoke Induce Endothelial Superoxide Anion Production via NADPH Oxidase Activation

  2004cited by this paper
• Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis

  2004cited by this paper
• Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

  2004cited by this paper
• Inhibition of interleukin-1beta reduces mouse lung inflammation induced by exposure to cigarette smoke.

  2004cited by this paper
• Toll-like receptors: function and roles in lung disease.

  2004cited by this paper
• Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells.

  2004cited by this paper
• Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease.

  2004cited by this paper
• Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

  2004cited by this paper
• Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse.

  2004cited by this paper
• Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

  2003influential reference
• Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses.

  2003cited by this paper
• Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.

  2003cited by this paper
• The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.

  2002cited by this paper
• The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

  2002cited by this paper
• Mucin apoprotein expression in COPD.

  2002cited by this paper
• Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown.

  2002cited by this paper
• Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke.

  2001cited by this paper
• I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations.

  2001cited by this paper
• Impaired Pulmonary NF-κB Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice

  2001cited by this paper
• Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils1

  2000cited by this paper
• Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion lung injury.

  2000cited by this paper
• Activators and target genes of Rel/NF-kappaB transcription factors.

  1999cited by this paper
• NADPH oxidase: an update.

  1999cited by this paper
• Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers.

  1999cited by this paper
• Bacterial endotoxin is an active component of cigarette smoke.

  1999cited by this paper
• Role of transcription factors in inflammatory lung diseases

  1998cited by this paper
• Systemic oxidative stress in asthma, COPD, and smokers.

  1996cited by this paper
• Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.

  1992cited by this paper
• Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

  1990cited by this paper
• Proteolytic activity of human neutrophil elastase and porcine pancreatic trypsin causes bronchial secretory cell metaplasia in hamsters.

  1985cited by this paper
• Free-radical chemistry of cigarette smoke and its toxicological implications.

  1985cited by this paper
• The effect of age on lung structure in male BALB/cNNia inbred mice.

  1984cited by this paper
• Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

  1978influential reference

• PPARG stimulation restored lung mRNA expression of core clock, inflammation‐ and metabolism‐related genes disrupted by reversed feeding in male mice

  2023cites this paper
• Effect of cigarette smoking on blood biochemical parameters in males of district Swabi Khyber Pakhtunkhwa Pakistan

  2022cites this paper
• Transcriptomic Evidence That Switching from Tobacco to Electronic Cigarettes Does Not Reverse Damage to the Respiratory Epithelium

  2022cites this paper
• Time‐dependent effect of inhaled cigarette smoke exposure in the bleomycin‐induced lung injury rat model

  2022cites this paper
• NADPH Oxidase Isoforms in COPD Patients and Acute Cigarette Smoke-Exposed Mice: Induction of Oxidative Stress and Lung Inflammation

  2022influential citation
• Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review

  2022cites this paper
• Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies

  2021cites this paper
• Smoking increases the premature associated senescence phenotype of circulating Endothelial Progenitor Cells

  2021cites this paper
• Inhalation exposure by cigarette smoke: Effects on the progression of bleomycin- and lipopolysaccharide-induced lung injuries in rat models.

  2021cites this paper
• Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling

  2021cites this paper
• Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3

  2021cites this paper
• RETRACTED ARTICLE: Protective effects of propolis extract against nicotine-evoked pulmonary and hepatic damage

  2021cites this paper
• Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

  2021cites this paper
• Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

  2020cites this paper
• Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease

  2020cites this paper
• Apocynin prevents cigarette smoking-induced loss of skeletal muscle mass and function by preserving proteostatic signalling

  2020cites this paper
• Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo.

  2020cites this paper
• Flavonoids as Cytokine Immunomodulators to Reduce Airway Inflammation via Inhibition of the NF‐κB Signalling Pathway: A Systematic Overview

  2020cites this paper
• The ageing lung under stress

  2020cites this paper
• Targeting oxidative stress for the treatment of COPD and its comorbidities

  2019cites this paper
• The roles of NADPH oxidase in modulating neutrophil effector responses

  2019cites this paper
• Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β‐catenin and AMPK pathways

  2018cites this paper
• Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke

  2018cites this paper
• Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox

  2017cites this paper
• Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling.

  2017cites this paper
• The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling

  2017cites this paper
• Functional, Cellular, and Molecular Remodeling of the Heart under Influence of Oxidative Cigarette Tobacco Smoke

  2017cites this paper
• Hypoxic pulmonary vasoconstriction in COPD-associated pulmonary hypertension: been there, done that?

  2017cites this paper
• RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase‐4‐Dependent Oxidative Stress Induced by Cigarette Smoke

  2017cites this paper
• European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

  2017cites this paper
• Catalase is more sensible to the inhibitory effect of soluble component of tobacco smoke than Glutathione Peroxidase and Superoxide Dismutase

  2017cites this paper
• Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide.

  2016cites this paper
• The effect of an IκB-kinase-β(IKKβ) inhibitor on tobacco smoke-induced pulmonary inflammation

  2016cites this paper
• ETHANOL EXTRACT OF MANGOSTEEN PEEL REDUCES HISTOLOGICAL COUNT OF ALVEOLAR MACROPHAGE AND PULMONARY ALVEOLAR SPACE SIZE IN MALE WHITE RATS (Rattus norvegicus) EXPOSED TO CIGARETTE SMOKE

  2016influential citation
• Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis

  2016cites this paper
• Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation*

  2015cites this paper
• Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

  2015cites this paper
• ACTIVATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADPH) OXIDASE (NOX) BY TYPE 1 RECEPTORS FOR ANGIOTENSIN II (ATII)

  2015cites this paper
• NOX Modifiers—Just a Step Away from Application in the Therapy of Airway Inflammation?

  2015cites this paper
• Angiotensin antagonist drugs as "source antioxidants" - Down- regulation of nicotinamide adenine dinucleotide phosphate oxidase activation mediates many of their protective benefits, independent of hypertension control

  2015cites this paper
• NADPH Oxidases in Lung Health and Disease

  2014cites this paper
• Smoking, Oxidative/Carbonyl Stress, and Regulation of Redox Signaling in Lung Inflammation

  2014cites this paper
• Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway

  2014cites this paper
• Innate immune cell migration and function in response to damage associated signals

  2014cites this paper
• Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways

  2014cites this paper
• Oxidants in Acute and Chronic Lung Disease

  2014cites this paper
• Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation.

  2013cites this paper
• Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke.

  2013cites this paper
• Toxicological Effects of the Different Substances in Tobacco Smoke on Human Embryonic Development by a Systems Chemo-Biology Approach

  2013cites this paper
• Reactive oxygen species in inflammation

  2013cites this paper
• Chapter 207 – Kinin Receptors

  2013cites this paper
• Reactive Oxygen Species, Kinase Signaling, and Redox Regulation of Epigenetics

  2013cites this paper
• Oxidative Stress and Chromatin Remodeling in Chronic Obstructive Pulmonary Disease and Smoking-Related Diseases

  2013cites this paper
• Cellular Response to Cigarette Smoke and Oxidants

  2012cites this paper
• Red in Translation Pulmonary Endothelial Cell NOX

  2012cites this paper
• Pulmonary endothelial cell NOX.

  2012cites this paper
• Tobacco Smoke Induces Ventricular Remodeling Associated with an Increase in NADPH Oxidase Activity

  2011cites this paper
• FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

  2011influential citation
• An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study

  2011cites this paper
• Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD.

  2011cites this paper
• Mate tea ameliorates emphysema in cigarette smoke-exposed mice

  2011cites this paper
• Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vitro in Preclinical Models, and in Smokers and Patients with Airways Disease

  2011cites this paper
• Interfering with Smoking‐Induced Pathophysiology

  2011cites this paper
• Environmental lung injury and pattern recognition receptors

  2011cites this paper
• Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice

  2011cites this paper
• Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages

  2010cites this paper
• NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

  2010cites this paper
• Cellular response to cigarette smoke and oxidants: adapting to survive.

  2010cites this paper
• Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.

  2010cites this paper
• NOX Enzymes in Acute Lung Injury

  2010cites this paper
• Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke.

  2010cites this paper
• Impaired macrophage function following bacterial stimulation in chronic granulomatous disease

  2009cites this paper
• Changes of ROS during a Two-day Ultra-marathon Race

  2009cites this paper
• Characterization of the ROS Production in Ischemia/Reperfusion-induced Lung Injury

  2009cites this paper
• Decreased PM10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53, p21, and CCND1 Modify This Effect

  2009influential citation
• Potential role of Noxes in the protection of mucosae: H(2)O(2) as a bacterial repellent.

  2009cites this paper
• Nicotinamide adenine dinucleotide phosphate oxidase inhibition: a new hope for sepsis therapy?

  2009cites this paper
• RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

  2009cites this paper
• Characterization of the ROS Production in Ischemia / Reperfusion-induced Lung Injury

  2009cites this paper
• The protective role of ROS in autoimmune disease.

  2009cites this paper