Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Organic and biomolecular chemistry

• Publication date

  2013-10-22

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1039/c3ob41885ePMID 24108414PMCID PMC3922537
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

  2013cited by this paper
• CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism1[W][OA]

  2012cited by this paper
• Characterization of CYP76M5–8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster*

  2012cited by this paper
• Unusual P450 reactions in plant secondary metabolism.

  2011cited by this paper
• Carnosol: a promising anti-cancer and anti-inflammatory agent.

  2011cited by this paper
• Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7

  2011cited by this paper
• CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice.

  2011cited by this paper
• Hydrocarbon hydroxylation by cytochrome P450 enzymes.

  2010cited by this paper
• Hydrocarbon hydroxylation by cytochrome P450 enzymes.

  2010cited by this paper
• Two rings in them all: the labdane-related diterpenoids.

  2010cited by this paper
• Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering

  2009cited by this paper
• A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

  2009cited by this paper
• A modular approach for facile biosynthesis of labdane-related diterpenes.

  2007cited by this paper
• New developments in the chemistry and biology of the bioactive constituents of tanshen

  2007cited by this paper
• Antioxidant activity and phenolic compounds in selected herbs.

  2001cited by this paper
• Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

  2001cited by this paper
• Determination of the Carnosic Acid Content in Wild and Cultivated Rosmarinus officinalis

  1998cited by this paper
• Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].

  1993cited by this paper
• Inhibitory Effect of Carnosolic Acid on HIV-1 Protease

  1992cited by this paper

• A physically linked CYP720B-diterpene synthase gene pair controls ferruginol biosynthesis in Taiwania cryptomerioides and reveals conserved genome organization in Cupressidae.

  2026cites this paper
• First stereoselective approach for structure revision of nagiol and syntheses of 2,3-dihydroxyferruginol and ferruginol.

  2025cites this paper
• Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae).

  2025cites this paper
• From Plants to Microbes: Harnessing Enzyme Promiscuity for Natural Product Synthesis.

  2025cites this paper
• Salicylic acid and seaweed extract increase essential oil production and alter the concentration of carnosic acid and carnosol in rosemary plants

  2025cites this paper
• Metabolite characteristics and molecular mechanism of different fruit color formation in hybrids from two Lycium species

  2025cites this paper
• Comparative transcriptomics of two Salvia subg. Perovskia species contribute towards molecular background of abietane-type diterpenoid biosynthesis

  2024cites this paper
• Double-barreled defense: dual ent-miltiradiene synthases in most rice cultivars

  2024cites this paper
• Evolution of Salvia key enzyme genes based on metabolomic and transcriptomic insights into mitochondrial quality control

  2024cites this paper
• Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

  2023cites this paper
• Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

  2023cites this paper
• Engineering of CYP82Y1, a cytochrome P450 monooxygenase: a key enzyme in noscapine biosynthesis in opium poppy.

  2023cites this paper
• Miltiradiene Production by Cytoplasmic Metabolic Engineering in Nicotiana benthamiana

  2023cites this paper
• Hydroxylases involved in terpenoid biosynthesis: a review

  2023cites this paper
• Biosynthesis and biotechnological production of the anti-obesity agent celastrol

  2023cites this paper
• Natural variation of diterpenoid phytoalexins in rice: Aromatic diterpenoid phytoalexins in specific cultivars.

  2023cites this paper
• Identification and functional characterization of three cytochrome P450 genes for the abietane diterpenoid biosynthesis in Isodon lophanthoides

  2023cites this paper
• The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis

  2023cites this paper
• Plant terpene specialized metabolism: complex networks or simple linear pathways?

  2023cites this paper
• Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

  2022cites this paper
• Plant (di)terpenoid evolution: from pigments to hormones and beyond

  2022cites this paper
• A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis

  2022cites this paper
• The Role of Ingenane Diterpenes in Cancer Therapy: From Bioactive Secondary Compounds to Small Molecules

  2022cites this paper
• Overcoming Metabolic Constraints in the MEP-Pathway Enrich Salvia sclarea Hairy Roots in Therapeutic Abietane Diterpenes

  2022cites this paper
• Research Progress on the Synthetic Biology of Botanical Biopesticides

  2022cites this paper
• Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis.

  2022cites this paper
• Progress in heterologous biosynthesis of forskolin

  2021cites this paper
• Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes.

  2021cites this paper
• Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons.

  2021cites this paper
• Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza

  2021cites this paper
• A review: biosynthesis of plant-derived labdane-related diterpenoids.

  2021cites this paper
• Recent Advances in the Synthetic Biology of Natural Drugs

  2021cites this paper
• Plant cytochrome P450 plasticity and evolution.

  2021cites this paper
• Multiscale Simulations on the Catalytic Plasticity of CYP76AH1

  2021cites this paper
• Cytochrome P450s in plant terpenoid biosynthesis: discovery, characterization and metabolic engineering

  2021cites this paper
• Structural insights revealed by crystal structures of CYP76AH1 and CYP76AH1 in complex with its natural substrate.

  2021cites this paper
• Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in S. sclarea Hairy Roots by Engineering the GGPPS and CPPS Genes

  2020cites this paper
• Grape terpenoids: flavor importance, genetic regulation, and future potential

  2020cites this paper
• Strategies for the production of biochemicals in bioenergy crops

  2020cites this paper
• Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

  2020cites this paper
• Enhance production of diterpenoids in yeast by overexpression of the fused enzyme of ERG20 and its mutant mERG20.

  2020cites this paper
• The biosynthesis of the anti‐microbial diterpenoid leubethanol in Leucophyllum frutescens proceeds via an all‐cis prenyl intermediate

  2020cites this paper
• Protein engineering strategies for microbial production of isoprenoids

  2020cites this paper
• Triptolide: reflections on two decades of research and prospects for the future.

  2020cites this paper
• Functional integration of two CYP450 genes involved in biosynthesis of tanshinones for improved diterpenoid production by synthetic biology.

  2020cites this paper
• Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza.

  2019cites this paper
• Discovery and Engineering of Cytochrome P450s for Terpenoid Biosynthesis.

  2019cites this paper
• Cytochrome P450 enzymes: A driving force of plant diterpene diversity.

  2019cites this paper
• Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare

  2019cites this paper
• CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast.

  2019cites this paper
• Research advances on CYP450-catalysed pharmaceutical terpenoids biosynthesis in plants.

  2019cites this paper
• Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid

  2019cites this paper
• Biochemical characterization of diterpene synthases of Taiwania cryptomerioides expands the known functional space of specialized diterpene metabolism in gymnosperms.

  2019cites this paper
• CMAUP: a database of collective molecular activities of useful plants

  2018cites this paper
• Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus‐castus

  2018cites this paper
• Plant diterpenoid metabolism for manufacturing the biopharmaceuticals of tomorrow: prospects and challenges

  2018cites this paper
• Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii

  2018cites this paper
• May 07, 2020 Biosynthesis of bioactive diterpenoids in the medicinal

  2018cites this paper
• Biosynthesis of bioactive ingredients of Salvia miltiorrhiza and advanced biotechnologies for their production

  2018cites this paper
• Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.

  2018cites this paper
• P450s controlling metabolic bifurcations in plant terpene specialized metabolism

  2017cites this paper
• Functional Diversi fi cation of Kaurene Synthase-Like Genes in Isodon rubescens 1 [ OPEN ]

  2017cites this paper
• Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

  2017influential citation
• Functional diversification of kaurene synthase-like genes

  2017cites this paper
• Functional Diversification of Kaurene Synthase-Like Genes in Isodon rubescens1[OPEN]

  2017cites this paper
• Elucidation of terpenoid metabolism in Scoparia dulcis by RNA-seq analysis

  2017cites this paper
• The terpene synthase gene family in Tripterygium wilfordii harbors a labdane‐type diterpene synthase among the monoterpene synthase TPS‐b subfamily

  2017cites this paper
• Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures1[OPEN]

  2017cites this paper
• Production of Putative Diterpene Carboxylic Acid Intermediates of Triptolide in Yeast

  2017cites this paper
• Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza.

  2016cites this paper
• Inhibition of Melanogenesis by Abietatriene from Vitex Trifolia Leaf Oil

  2016cites this paper
• Carnosic acid biosynthesis elucidated by a synthetic biology platform

  2016cites this paper
• Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

  2016cites this paper
• Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast

  2016cites this paper
• Monoterpenol Oxidative Metabolism: Role in Plant Adaptation and Potential Applications

  2016cites this paper
• Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi.

  2015cites this paper
• Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis

  2015cites this paper
• Enzymes for synthetic biology of ambroxide-related diterpenoid fragrance compounds.

  2015cites this paper
• Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering.

  2015cites this paper
• The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid

  2015cites this paper
• Carnosic acid.

  2015influential citation
• Plant Omics: Isolation, Identification, and Expression Analysis of Cytochrome P450 Gene Sequences from Coleus forskohlii

  2015cites this paper
• Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes

  2015cites this paper
• Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis.

  2015cites this paper
• Diterpenoids of terrestrial origin.

  2015cites this paper
• Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis

  2015cites this paper
• Cytochromes P450 for terpene functionalisation and metabolic engineering.

  2015cites this paper
• Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast.

  2015cites this paper
• Aromatic abietane diterpenoids: their biological activity and synthesis.

  2015cites this paper
• Computational Identification and Systematic Classification of Novel Cytochrome P450 Genes in Salvia miltiorrhiza

  2014cites this paper
• Biosynthesis of Lycosantalonol, a cis-Prenyl Derived Diterpenoid

  2014cites this paper
• To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism.

  2014cites this paper
• Dual Function of the Cytochrome P450 CYP76 Family from Arabidopsis thaliana in the Metabolism of Monoterpenols and Phenylurea Herbicides1[W][OPEN]

  2014cites this paper
• Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes.

  2014cites this paper
• The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism.

  2014cites this paper
• High-level diterpene production by transient expression in Nicotiana benthamiana

  2013cites this paper
• Diterpenoids of terrestrial origin.

  2012cites this paper