PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  European Heart Journal

• Publication date

  2014-09-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1093/eurheartj/eht496PMID 24334406
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PI3K p110α Isoform-Dependent Rho GTPase Rac1 Activation Mediates H2S-Promoted Endothelial Cell Migration via Actin Cytoskeleton Reorganization

  2012cited by this paper
• Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

  2011cited by this paper
• Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.

  2011cited by this paper
• Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis.

  2011cited by this paper
• Comparison of zotarolimus-eluting and everolimus-eluting coronary stents.

  2010cited by this paper
• Laminin receptor activation inhibits endothelial tissue factor expression.

  2010cited by this paper
• Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents.

  2010cited by this paper
• Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes.

  2010cited by this paper
• Edinburgh Research Explorer The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1

  2010cited by this paper
• Drug-eluting stents: a reappraisal

  2010cited by this paper
• Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention.

  2010cited by this paper
• The emerging mechanisms of isoform-specific PI3K signalling

  2010cited by this paper
• Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and inducing apoptosis of endothelial progenitor cells.

  2010cited by this paper
• The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1

  2010cited by this paper
• A prospective, randomized, 6-month comparison of the coronary vasomotor response associated with a zotarolimus- versus a sirolimus-eluting stent: differential recovery of coronary endothelial dysfunction.

  2009cited by this paper
• Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K.

  2009cited by this paper
• Regulation of phosphoinositide 3-kinase expression in health and disease.

  2009cited by this paper
• Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants

  2009cited by this paper
• Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation.

  2009cited by this paper
• Six-month comparison of coronary endothelial dysfunction associated with sirolimus-eluting stent versus Paclitaxel-eluting stent.

  2008cited by this paper
• Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

  2008cited by this paper
• Release of TNF-α during stent implantation into saphenous vein aortocoronary bypass grafts and its relation to plaque extrusion and restenosis

  2007cited by this paper
• Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2 -a]pyridines as novel PI3 kinase p110α inhibitors

  2007cited by this paper
• Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents.

  2007cited by this paper
• Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform

  2007cited by this paper
• Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing

  2007cited by this paper
• Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform.

  2007cited by this paper
• Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.

  2007cited by this paper
• FK506 Binding Protein 12/12.6 Depletion Increases Endothelial Nitric Oxide Synthase Threonine 495 Phosphorylation and Blood Pressure

  2007cited by this paper
• Cadherins, RhoA, and Rac1 Are Differentially Required for Stretch-Mediated Proliferation in Endothelial Versus Smooth Muscle Cells

  2007influential reference
• Drug-Eluting Stent and Coronary Thrombosis: Biological Mechanisms and Clinical Implications

  2007cited by this paper
• Paclitaxel Enhances Thrombin-Induced Endothelial Tissue Factor Expression via c-Jun Terminal NH2 Kinase Activation

  2006influential reference
• Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

  2006cited by this paper
• A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

  2006cited by this paper
• A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

  2006cited by this paper
• Effects of Tacrolimus or Sirolimus on Proliferation of Vascular Smooth Muscle and Endothelial Cells

  2006cited by this paper
• Late angiographic stent thrombosis (LAST) events with drug-eluting stents.

  2005cited by this paper
• PDGF receptor kinase inhibitors for the treatment of restenosis.

  2005cited by this paper
• Rapamycin, but Not FK-506, Increases Endothelial Tissue Factor Expression: Implications for Drug-Eluting Stent Design

  2005cited by this paper
• Reconstituted High-Density Lipoprotein Inhibits Thrombin-Induced Endothelial Tissue Factor Expression Through Inhibition of RhoA and Stimulation of Phosphatidylinositol 3-Kinase but not Akt/Endothelial Nitric Oxide Synthase

  2004cited by this paper
• One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent: The TAXUS-IV Trial

  2004cited by this paper
• Preclinical restenosis models and drug-eluting stents: still important, still much to learn.

  2004cited by this paper
• A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease.

  2004cited by this paper
• Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS).

  2003cited by this paper
• Comparative study of cyclosporine and tacrolimus vs newer immunosuppressants mycophenolate mofetil and rapamycin on coronary endothelial function.

  2002cited by this paper
• A RANDOMIZED COMPARISON OF A SIROLIMUS-ELUTING STENT WITH A STANDARD STENT FOR CORONARY REVASCULARIZATION

  2002cited by this paper
• A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization.

  2002cited by this paper
• Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

  2001cited by this paper
• Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase*

  1999cited by this paper
• Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase*

  1998cited by this paper
• Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

  1998cited by this paper
• Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels. Implications for venous bypass graft failure.

  1997cited by this paper
• Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

  1997cited by this paper
• Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow.

  1997cited by this paper
• An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

  1995cited by this paper

• Mendelian randomization identifies causal effects of phospholipids on portal vein thrombosis risk: FADS1/2-mediated pathways and their potential as diagnostic biomarkers

  2026cites this paper
• Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing

  2025cites this paper
• Targeted NAD+ repletion via biomimetic nanoparticle enables simultaneous management of intimal hyperplasia and accelerated re-endothelialization: A proof-of-concept study toward next-generation of endothelium-protective, anti-restenotic therapy.

  2024cites this paper
• An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis After Angioplasty

  2024cites this paper
• PIK3CA-Related Disorders: From Disease Mechanism to Evidence-Based Treatments.

  2024cites this paper
• Neointima abating and endothelium preserving - An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L.

  2023cites this paper
• Angioplasty induces epigenomic remodeling in injured arteries

  2022cites this paper
• Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability

  2022cites this paper
• PI3K Isoforms in Vascular Biology, A Focus on the Vascular System-Immune Response Connection.

  2022cites this paper
• Laser Additive Manufacturing of Anti-Tetrachiral Endovascular Stents with Negative Poisson’s Ratio and Favorable Cytocompatibility

  2022cites this paper
• Microfibrillar-associated protein 4 in health and disease.

  2022cites this paper
• Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway

  2021cites this paper
• PERK Inhibition Mitigates Restenosis and Thrombosis

  2020cites this paper
• PERK Inhibition Promotes Post-angioplasty Re-endothelialization via Modulating SMC Phenotype Changes

  2020cites this paper
• Angioplasty-induced epigenomic remodeling entails BRD4 and EZH2 hierarchical regulations

  2020cites this paper
• Isoform-Selective PI3K Inhibitors for Various Diseases.

  2020cites this paper
• PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm

  2019cites this paper
• Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.

  2019cites this paper
• The blood compatibility challenge Part 4: Surface modification for hemocompatible materials: passive and active approaches to guide blood-material interactions.

  2019cites this paper
• Deletion of the FHL2 gene attenuates intima‐media thickening in a partially ligated carotid artery ligated mouse model

  2019cites this paper
• Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction.

  2018cites this paper
• PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism

  2018cites this paper
• Impact of PI3K&agr; (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis

  2018cites this paper
• Bioresorbable Scaffold-Based Controlled Drug Delivery for Restenosis

  2018cites this paper
• Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats

  2017cites this paper
• Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol

  2017cites this paper
• SGK1 up-regulates Orai1 expression and VSMC migration during neointima formation after arterial injury

  2017cites this paper
• Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells

  2016cites this paper
• Delayed reendothelialization with rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries

  2016cites this paper
• Saikosaponin-a attenuates oxidized LDL uptake and prompts 3 cholesterol efflux in THP-1 cells

  2016cites this paper
• Local arterial wall drug delivery using balloon catheter system.

  2016cites this paper
• MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation

  2016cites this paper
• Endothelial Repair and Regeneration Following Intimal Injury

  2016cites this paper
• Bioresorbable vascular scaffolds: Biodegradation, drug delivery and vascular remodeling.

  2016cites this paper
• Carbamylated Low-Density Lipoproteins Induce a Prothrombotic State Via LOX-1: Impact on Arterial Thrombus Formation In Vivo.

  2016cites this paper
• Class IA Phosphatidylinositol 3-Kinase Isoform p110&agr; Mediates Vascular Remodeling

  2015cites this paper
• PI3K/Akt in platelet integrin signaling and implications in thrombosis.

  2015cites this paper
• Pathophysiologie der arteriellen Gefäßerkrankung und neue Therapieansätze

  2015cites this paper
• PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms.

  2015cites this paper
• Myristoylated Alanine‐Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation

  2015cites this paper
• XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling

  2015cites this paper
• Cardiovascular computed tomography: highlights of latest research presented at the 2014 Congress of the European Society of Cardiology.

  2014cites this paper