Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization

The survival motor neuron (SMN) is known to be involved in the biogenesis of small nuclear RNPs. This study provides evidence that the SMN may also be involved in axonal trafficking of mRNPs. Specifically, in situ hybridization and immuno-fluorescence experiments indicate that many SMN-associated mRNPs are found in neurites and axons, suggesting that SMN deficiency might result in mislocalization of mRNAs required for axonogenesis.

• Publication year

  2013

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1261/rna.040204.113PMID 24152552PMCID 3884661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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