ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cancer Research

• Publication date

  2008-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-08-0548PMID 19010931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Matrix metalloproteinases at cancer tumor-host interface.

  2008cited by this paper
• Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.

  2008cited by this paper
• MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease

  2008cited by this paper
• ADAMs in cancer cell proliferation and progression

  2007cited by this paper
• ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice

  2007cited by this paper
• The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases

  2007cited by this paper
• Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion.

  2007cited by this paper
• The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

  2007cited by this paper
• ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma.

  2007cited by this paper
• Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer

  2006cited by this paper
• Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively

  2006cited by this paper
• Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC)

  2006cited by this paper
• ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma

  2006cited by this paper
• Fibroblasts in cancer

  2006influential reference
• Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer.

  2006cited by this paper
• Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species

  2006cited by this paper
• Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.

  2006cited by this paper
• Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo

  2006influential reference
• Collagenases in cancer.

  2005influential reference
• Supplemental Data Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

  2005cited by this paper
• ADAMTS1 Proteinase Is Up-regulated in Wounded Skin and Regulates Migration of Fibroblasts and Endothelial Cells*

  2005cited by this paper
• Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma

  2004cited by this paper
• The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential.

  2004cited by this paper
• Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo

  2004cited by this paper
• A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.

  2004cited by this paper
• Improved quantification of angiogenesis in the rat aortic ring assay

  2004cited by this paper
• Reconstruction of functionally normal and malignant human breast tissues in mice.

  2004cited by this paper
• Friends or foes — bipolar effects of the tumour stroma in cancer

  2004influential reference
• ADAMTS1: A Matrix Metalloprotease with Angioinhibitory Properties

  2003cited by this paper
• ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165*

  2003cited by this paper
• Matrix metalloproteinases in cancer.

  2002influential reference
• Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

  2002cited by this paper
• Expression of METH-1 and METH-2 in pancreatic cancer.

  2001cited by this paper
• Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.

  2001cited by this paper
• Know thy neighbor: stromal cells can contribute oncogenic signals.

  2001cited by this paper
• An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.

  2000influential reference
• The Hallmarks of Cancer Review

  2000cited by this paper
• Expression and regulation of collagenase‐3 (MMP‐13) in human malignant tumors

  1999cited by this paper
• A Novel Host/Tumor Cell Interaction Activates Matrix Metalloproteinase 1 and Mediates Invasion through Type I Collagen*

  1999influential reference
• Inhibition of stromal matrix metalloproteases: Effects on breast‐tumor promotion by fibroblasts

  1998cited by this paper
• In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

  1998cited by this paper
• cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.

  1997cited by this paper
• Factors influencing myofibroblast differentiation during wound healing and fibrosis.

  1995cited by this paper
• Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.

  1994influential reference
• Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts.

  1993influential reference
• Modulation of collagen and fibronectin synthesis in fibroblasts by normal and malignant cells

  1992cited by this paper
• Growth and differentiation of human gastrointestinal adenocarcinoma stem cells in soft agarose.

  1981cited by this paper
• Two Improved and Simplified Methods for the Spectrophotometric Determination of Hydroxyproline.

  1963cited by this paper
• Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium

  year unknowncited by this paper

• C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

  2025cites this paper
• The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system

  2025cites this paper
• Gene expression and immunohistochemistry analysis of ADAMTS-1 and its substrates in odontogenic keratocyst

  2025cites this paper
• Activation of G Protein-Coupled Estrogen Receptor Induces p53 and ADAMTS1 to Inhibit Tumor Growth and Suppress Liver Cancer Metastasis

  2025cites this paper
• Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma

  2024cites this paper
• Enhanced Cytotoxic Activity of PEGylated Curcumin Derivatives: Synthesis, Structure–Activity Evaluation, and Biological Activity

  2023cites this paper
• Genes with dual proto-oncogene and tumor suppressor gene activities are frequently altered by protein losses in colon cancers.

  2023cites this paper
• Effect of non-surgical periodontal therapy (NSPT) on salivary and serum levels of a disintegrin-like and metalloproteinase with thrombospondin-1 (ADAMTS-1)

  2022cites this paper
• The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy

  2021cites this paper
• Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

  2021cites this paper
• Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells

  2020cites this paper
• ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

  2020cites this paper
• Overexpression of AGR2 Is Associated With Drug Resistance in Mutant Non-small Cell Lung Cancers

  2020cites this paper
• ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila

  2019cites this paper
• Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs

  2019cites this paper
• Role of cancer associated fibroblasts in macrophage recruitment in head and neck cancer

  2018cites this paper
• Evaluation of Tumor Vasculature Using a Syngeneic Tumor Model in Wild-Type and Genetically Modified Mice.

  2018cites this paper
• ADAMTS‐1 disrupts HGF/c‐MET signaling and HGF‐stimulated cellular processes in fibrosarcoma

  2018cites this paper
• The extracellular matrix in cancer progression: Role of hyalectan proteoglycans and ADAMTS enzymes.

  2017cites this paper
• Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

  2017cites this paper
• Matrix Metalloproteinases (MMPs) in Cancer Initiation and Progression

  2017cites this paper
• ADAMTS1-mediated targeting of TSP-1 by PPARδ suppresses migration and invasion of breast cancer cells

  2017cites this paper
• Pathophysiological Aspects of Proteases

  2017influential citation
• Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis

  2016cites this paper
• Molecular mechanisms associated with breast cancer based on integrated gene expression profiling by bioinformatics analysis

  2016cites this paper
• ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells

  2016cites this paper
• Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

  2016cites this paper
• Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer.

  2016influential citation
• SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic conditions in hepatoma cells.

  2016cites this paper
• TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.

  2015cites this paper
• miR‑365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer.

  2015cites this paper
• ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo

  2015cites this paper
• Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells

  2014cites this paper
• Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1

  2014cites this paper
• ADAMTS-18: a metalloproteinase with multiple functions.

  2014cites this paper
• ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor.

  2014cites this paper
• Análise imunohistoquímica da ADAMTS-1 e proteoglicanos no ameloblastoma e no tumor odontogênico cístico calcificante

  2014cites this paper
• Mithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors

  2013cites this paper
• Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen‐1 and nidogen‐2

  2013cites this paper
• The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways

  2013cites this paper
• Increased expression of ADAMTS13 mRNA correlates with ischemic cerebrovascular disease in systemic lupus erythematosus patients

  2013cites this paper
• Chapter 260 – ADAMTS1

  2013cites this paper
• Expression of ADAMTS1 and Its Correlation with Angiogenesis in Primary Gastric Cancer and Lymph Node Metastasis

  2013cites this paper
• Apoptosis and tumor inhibition by ADAMTS 1-1The tumor growth inhibitory effect of ADAMTS 1 is accompanied by the inhibition of tumor angiogenesis

  2013cites this paper
• Proteases in Cancer: Significance for Invasion and Metastasis

  2013cites this paper
• Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion

  2013cites this paper
• Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes.

  2012cites this paper
• Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

  2012cites this paper
• Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis

  2012cites this paper
• Curcumin–cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer

  2012cites this paper
• The dual role of fibulins in tumorigenesis.

  2012cites this paper
• The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

  2012cites this paper
• Emerging Roles of ADAMTSs in Angiogenesis and Cancer

  2012cites this paper
• The SEC family of RNA Polymerase II elongation factors: gene

  2012cites this paper
• Gene expression profile of ADAMs and ADAMTSs metalloproteinases in normal and malignant plasma cells and in the bone marrow environment.

  2011cites this paper
• Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta

  2011cites this paper
• Inhibition of tumor growth by antibody to ADAMTS1 in mouse xenografts of breast cancer.

  2011cites this paper
• Isolation and identification of a distinct side population cancer cells in the human epidermal squamous cancer cell line A431

  2011cites this paper
• The Role of the Myofibroblast in Fibrosis and Cancer Progression

  2011cites this paper
• Células MCF-7 como modelo 3D no estudo de câncer de mama humano.

  2011cites this paper
• Modulation of immunopathogenic matrix metalloproteinases in pulmonary tuberculosis by T helper-17 cytokines & the PI 3-kinase pathway

  2011cites this paper
• The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis.

  2011cites this paper
• Tumorigenesis and Neoplastic Progression The ADAMTS 1 Protease Gene Is Required for Mammary Tumor Growth and Metastasis

  2011cites this paper
• The ADAMTS1 protease gene is required for mammary tumor growth and metastasis.

  2011cites this paper
• ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1)

  2011cites this paper
• Tumor and Stem Cell Biology Cancer Research ADAMTS 1 Contributes to the Acquisition of an Endothelial-like Phenotype in Plastic Tumor Cells

  2010cites this paper
• ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells.

  2010cites this paper
• Matrix metalloproteinases: regulators of the tumor microenvironment.

  2010cites this paper
• Bioinorganic aspects of angiogenesis.

  2010cites this paper
• The role of ADAMTSs in arthritis

  2010cites this paper
• ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors

  2010cites this paper
• Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis

  2010cites this paper
• Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1

  2009cites this paper
• Loss of SKI Expression in Testicular Cancer Leads to an Enhanced Invasive Phenotype Through Both BMP-Dependent and BMP-Independent Pathways

  2009cites this paper
• The recruitment of stromal cells to the site of tumor formation

  2009cites this paper
• ADAMTS1, a putative anti‐angiogenic factor, is decreased in human prostate cancer

  2009cites this paper
• The Cleavage of Semaphorin 3C Induced by ADAMTS1 Promotes Cell Migration*

  2009cites this paper
• Open Access Rheumatology Research and Reviews Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article the Emerging Roles of Adamts-7 and Adamts-12 Matrix Metalloproteinases

  year unknowncites this paper
• Tumor and Stem Cell Biology Adamts1 Contributes to the Acquisition of an Endothelial-like Phenotype in Plastic Tumor Cells

  year unknowncites this paper