Neutrophils, NETs, NETosis - old or new factors in sepsis and septic shock?

M. Lipińska-Gediga

Published 2017 in Anaesthesiology Intensive Therapy

ABSTRACT

Neutrophils are an key part of the innate immune system in the host's defences against pathogens. Circulating neutrophils are recruited at the sites of infection or sterile inflammation in response to pathogen and host-derived inflammatory mediators. In addition to phagocytosis and degranulation, neutrophils display the release of NETs in order to restrain infection. NETs are able to entrap and kill microbes, and display proinflammatory and prothrombotic properties.

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