Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPENDO.2001.281.2.E217PMID 11440896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of hyperinsulinemia on amino acid utilization in the ovine fetus.

  2000cited by this paper
• Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia.

  2000cited by this paper
• Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals

  1999cited by this paper
• Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells.

  1998cited by this paper
• Growth factors and the regulation of fetal growth.

  1998cited by this paper
• Effect of Insulin on Farnesyltransferase

  1998cited by this paper
• Hyperinsulinemia potentiates activation of p21Ras by growth factors.

  1997cited by this paper
• The Ras superfamily of GTPases 1

  1996cited by this paper
• Effect of Insulin on Farnesyltransferase Activity in 3T3-L1 Adipocytes*

  1996cited by this paper
• Protein prenylation: molecular mechanisms and functional consequences.

  1996cited by this paper
• Regulation of Ras-mediated signalling: more than one way to skin a cat.

  1995cited by this paper
• Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange.

  1994cited by this paper
• The ras Superfamily of GTPases

  1993cited by this paper
• Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

  1993cited by this paper
• Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

  1993cited by this paper
• Fetal Macrosomia in the Diabetic Patient

  1992cited by this paper
• Sequence dependence of protein isoprenylation.

  1991cited by this paper
• Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

  1990cited by this paper
• Transplacental passage of insulin in pregnant women with insulin‐dependent diabetes mellitus. Its role in fetal macrosomia

  1990cited by this paper
• Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects of Physiologic Hyperinsulinemia on Fetal Growth and Composition

  1984cited by this paper
• Banting Lecture 1980: of Pregnancy and Progeny

  1980cited by this paper
• Weight and length at birth of infants of diabetic mothers.

  1954cited by this paper

• Ultrasonographic Evaluation of Fetal Liver, Pancreas, Thymus, and Adrenal Glands in Diabetic Versus Non‐Diabetic Pregnancies

  2025cites this paper
• Insight into the Post-Translational Modifications in Pregnancy and Related Complications

  2024cites this paper
• Hyperinsulinemia in Obesity, Inflammation, and Cancer

  2021cites this paper
• Pathophysiology of placenta and fetus in diabetes mellitus

  2018cites this paper
• Nutrient delivery and metabolism in the fetus

  2018cites this paper
• Fetal Requirements and Placental Transfer of Nitrogenous Compounds

  2017cites this paper
• Effects of hypothyroidism on pancreatic islet development and tissue insulin signalling pathways in the ovine fetus

  2016cites this paper
• Comparing the size and weight of placenta and birth weight in normal pregnancy and gestational diabetes: brief report

  2015cites this paper
• Long-Term Outcomes After Intrauterine Therapy of the Growth-Restricted Fetus

  2014cites this paper
• Responses of the embryonic epigenome to maternal diabetes.

  2012cites this paper
• Mechanisms Underlying the Effects of Physical Activity on Cancer

  2011cites this paper
• Diabetic embryopathy: a role for the epigenome?

  2011cites this paper
• Signaling mechanisms for oxidized LDL-induced oxidative stress and the upregulation of plasminogen activator inhibitor-I in vascular cells

  2010cites this paper
• Maternal-Fetal Nutrition during Pregnancy and Lactation: Pregnancy and feto-placental growth: macronutrients

  2010cites this paper
• Mitogenic action of insulin: friend, foe or ‘frenemy’?

  2010cites this paper
• Translocation of H-Ras and its implications in the development of diabetic retinopathy.

  2009influential citation
• Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy.

  2008cites this paper
• Placental-fetal glucose exchange and fetal glucose metabolism.

  2006cites this paper
• Recent observations on the regulation of fetal metabolism by glucose

  2006cites this paper
• Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes.

  2006cites this paper
• Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle.

  2005cites this paper
• Chapter 1 Regulation of metabolism and growth during prenatal life

  2005cites this paper
• Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats.

  2004cites this paper
• Dominant negative α-subunit of farnesyl- and geranylgeranyl-transferase I inhibits insulin-induced differentiation of 3T3-L1 pre-adipocytes

  2003cites this paper
• Dominant negative alpha-subunit of FTase inhibits effects of insulin and IGF-I in MCF-7 cells.

  2002cites this paper
• Dominant Negative α-Subunit of FTase Inhibits Effects of Insulin and IGF-I in MCF-7 Cells

  2002cites this paper
• Intrauterine growth restriction

  2001cites this paper