The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Virology

• Publication date

  1994-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/VIRO.1994.1306PMID 8184549
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The products of the E5, E6, or E7 open reading frames of RhPV 1 can individually transform NIH 3T3 cells or in cotransfections with activated ras can transform primary rodent epithelial cells.

  1993cited by this paper
• E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts.

  1993cited by this paper
• Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.

  1993cited by this paper
• Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

  1993cited by this paper
• Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

  1992cited by this paper
• Expression and splicing patterns of human papillomavirus type‐16 mrnas in pre‐cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers

  1992cited by this paper
• Differences in transforming activity and coded amino acid sequence among E6 genes of several papillomaviruses associated with epidermodysplasia verruciformis.

  1992cited by this paper
• The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

  1992cited by this paper
• Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.

  1992cited by this paper
• The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

  1991cited by this paper
• The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

  1991cited by this paper
• Quantitative detection of spliced E6-E7 transcripts of human papillomavirus type 16 in cervical premalignant lesions.

  1991cited by this paper
• The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

  1991cited by this paper
• Evidence of prevalent genital-type human papillomavirus infections in adults and children.

  1990cited by this paper
• The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.

  1989cited by this paper
• Improved retroviral vectors for gene transfer and expression.

  1989cited by this paper
• Identification of a transforming gene of human papillomavirus type 16

  1989cited by this paper
• HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

  1989cited by this paper
• The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

  1989cited by this paper
• The primary structure of major viral RNA in a rat cell line transfected with type 47 human papillomavirus DNA and the transforming activity of its cDNA and E6 gene.

  1989cited by this paper
• Comparison of the in vitro transforming activities of human papillomavirus types.

  1988cited by this paper
• The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

  1988cited by this paper
• Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

  1988cited by this paper
• Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

  1988cited by this paper
• Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter.

  1988cited by this paper
• Involvement of human papillomavirus type 8 genes E6 and E7 in transformation and replication

  1988cited by this paper
• The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

  1988cited by this paper
• Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas

  1988cited by this paper
• Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers

  1988cited by this paper
• The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells

  1987cited by this paper
• Human papillomavirus type 16 transformation of rat 3Y1 cells.

  1987cited by this paper
• The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

  1987cited by this paper
• Identification of the HPV‐16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

  1987cited by this paper
• Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

  1987cited by this paper
• Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.

  1987cited by this paper
• Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas.

  1987cited by this paper
• Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

  1987cited by this paper
• Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

  1986cited by this paper
• Cloning of monomeric human papillomavirus type 16 DNA integrated within cell DNA from a cervical carcinoma

  1986cited by this paper
• In situ hybridization detection of human papillomavirus DNAs and messenger RNAs in genital condylomas and a cervical carcinoma.

  1986cited by this paper
• Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

  1986cited by this paper
• Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells

  1986cited by this paper
• Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.

  1985cited by this paper
• Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

  1985cited by this paper
• Isolation of a transforming sequence from a human bladder carcinoma cell line.

  1982cited by this paper
• Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

  1981cited by this paper

• Too many cooks in the kitchen: HPV driven carcinogenesis – The result of collaboration or competition?

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• The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis

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• The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

  2021cites this paper
• In Silico Analysis of HPV E6 as Drug Target with Natural Antioxidants

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• The potential of RNA as a target for national screening of pre-cancer

  2018cites this paper
• Senescence induction; a possible cancer therapy

  2009cites this paper
• HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function.

  2008cites this paper
• Computational prediction of nuclear localization signals and structural characteristics of 91 types of HPV E6 proteins.

  2008cites this paper
• Human Papillomavirus E 6 Proteins Mediate Resistance to Interferon-Induced Growth Arrest through Inhibition of p 53 Acetylation

  2007cites this paper
• Human Papillomavirus E6 Proteins Mediate Resistance to Interferon-Induced Growth Arrest through Inhibition of p53 Acetylation

  2007cites this paper
• The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.

  2007cites this paper
• Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence

  2004cites this paper
• Abolition of Cyclin-Dependent Kinase Inhibitor p16Ink4a and p21Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

  2003cites this paper
• Human papillomavirus E6 protein interactions

  2002cites this paper
• A Mutant of Human Papillomavirus Type 16 E6 Deficient in Binding (cid:2) -Helix Partners Displays Reduced Oncogenic Potential In Vivo

  2002cites this paper
• A Mutant of Human Papillomavirus Type 16 E6 Deficient in Binding α-Helix Partners Displays Reduced Oncogenic Potential In Vivo

  2002cites this paper
• The function of the human papillomavirus oncogenes

  2001cites this paper
• The Human Papillomavirus E6 protein and its contribution to malignant progression

  2001cites this paper
• Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.

  2000cites this paper
• Human papillomavirus oncogenesis.

  2000cites this paper
• Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene.

  2000cites this paper
• The papillomavirus E6 proteins.

  1998cites this paper
• Identification of an α Helical Motif Sufficient for Association with Papillomavirus E6*

  1998cites this paper
• The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

  1998cites this paper
• Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16

  1996cites this paper
• Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

  1996cites this paper
• The serine protease inhibitors TLCK and TPCK inhibit the in vitro immortalization of primary human keratinocytes by HPV-18 DNA.

  1996cites this paper
• Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation

  1996cites this paper
• Splice sites of human papillomavirus type 16 E6 gene or heterologous gene required for transformation by E7 and accumulation of E7 RNA

  1995cites this paper
• The expression levels of the human papillomavirus type 16 E7 correlate with its transforming potential.

  1995cites this paper
• Papillomaviruses as Promoting Agents in Human Epithelial Tumors

  1995cites this paper
• DNA Tumor Viruses

  1995cites this paper