The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cytokine

• Publication date

  2012-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cyto.2012.04.044PMID 22633286
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells.

  2011cited by this paper
• Characterization of human FHL2 transcript variants and gene expression regulation in hepatocellular carcinoma.

  2011cited by this paper
• FHL2 suppresses growth and differentiation of the colon cancer cell line HT-29.

  2010cited by this paper
• Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

  2008cited by this paper
• Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response.

  2007cited by this paper
• The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.

  2007cited by this paper
• The multifunctional roles of the four-and-a-half-LIM only protein FHL2

  2006cited by this paper
• FHL2/SLIM3 Decreases Cardiomyocyte Survival by Inhibitory Interaction With Sphingosine Kinase-1

  2006cited by this paper
• Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.

  2005cited by this paper
• Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.

  2004cited by this paper
• p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.

  2004cited by this paper
• p38 Isoforms Have Opposite Effects on AP-1-dependent Transcription through Regulation of c-Jun

  2003cited by this paper
• CD40-Mediated Transcriptional Regulation of the IL-6 Gene in B Lymphocytes: Involvement of NF-κB, AP-1, and C/EBP1

  2003cited by this paper
• The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1

  2003cited by this paper
• The LIM-only protein FHL2 interacts with β-catenin and promotes differentiation of mouse myoblasts

  2002cited by this paper
• Missing pieces in the NF-kappaB puzzle.

  2002cited by this paper
• TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF‐κB activation

  2002cited by this paper
• Expression of FHL2 and cytokine messenger RNAs in human myocardium after cardiopulmonary bypass.

  2002cited by this paper
• The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

  2002cited by this paper
• Lower Limb Ischemia-Reperfusion Injury Triggers a Systemic Inflammatory Response and Multiple Organ Dysfunction

  2002cited by this paper
• Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐κB and downregulation of AP‐1 activities

  2001cited by this paper
• Production of IL-6 by human myoblasts stimulated with Abeta: relevance in the pathogenesis of IBM.

  2001cited by this paper
• Production of IL-6 by human myoblasts stimulated with Aβ

  2001cited by this paper
• Exercise and cytokines with particular focus on muscle-derived IL-6.

  2001cited by this paper
• p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system.

  2000cited by this paper
• A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM

  2000cited by this paper
• Muscle contractions induce interleukin‐6 mRNA production in rat skeletal muscles

  2000cited by this paper
• FHL2 (SLIM3) Is Not Essential for Cardiac Development and Function

  2000cited by this paper
• Dral Is a P53-Responsive Gene Whose Four and a Half Lim Domain Protein Product Induces Apoptosis

  2000cited by this paper
• Regulation of muscle regulatory factors by DNA‐binding, interacting proteins, and post‐transcriptional modifications

  2000cited by this paper
• Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice

  2000cited by this paper
• Gene expression pattern Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system

  2000cited by this paper
• Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes

  1999cited by this paper
• Stress-induced Stimulation of Early Growth Response Gene-1 by p38/Stress-activated Protein Kinase 2 Is Mediated by a cAMP-responsive Promoter Element in a MAPKAP Kinase 2-independent Manner*

  1999cited by this paper
• Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions.

  1999cited by this paper
• Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.

  1998cited by this paper
• An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

  1998cited by this paper
• The Pathophysiologic Roles of Interleukin-6 in Human Disease

  1998cited by this paper
• Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.

  1998cited by this paper
• Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

  1997cited by this paper
• TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

  1996cited by this paper
• Stress activated cytokines and the heart.

  1996cited by this paper
• NF-κB: Ten Years After

  1996cited by this paper
• Interleukin-6 secreted from human myxoma reduces murine viral myocarditis.

  1996cited by this paper
• NF-kappa B: ten years after.

  1996cited by this paper
• TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.

  1996cited by this paper
• An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.

  1996cited by this paper
• An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

  1996cited by this paper
• Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation.

  1992cited by this paper

• FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

  2025cites this paper
• FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways

  2025cites this paper
• The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal Intestine

  2024cites this paper
• FHL2 expression by cancer‐associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma

  2024cites this paper
• The roles of FHL2 as a mechanotransducer for cellular functions in the mechanical environment

  2024cites this paper
• Effects of hemodynamic load on cardiac remodeling in fish and mammals: the value of comparative models.

  2024cites this paper
• Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart.

  2024cites this paper
• fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles

  2024cites this paper
• FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3

  2023cites this paper
• FHL2 Regulates Proliferation Differentiation and Autophagy of Bovine Skeletal Muscle Satellite Cells Through Wnt/β-catenin Signaling Pathway

  2022cites this paper
• Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma

  2022cites this paper
• miR-377 Inhibits Proliferation and Differentiation of Bovine Skeletal Muscle Satellite Cells by Targeting FHL2

  2022cites this paper
• PDLIM5 Affects Chicken Skeletal Muscle Satellite Cell Proliferation and Differentiation via the p38-MAPK Pathway

  2021cites this paper
• The novel six LIM and one PET domain-containing protein Lmpt is involved in the immune response through activation of the NF-κB signalling pathway in Macrobrachium nipponense.

  2020cites this paper
• Expression, location, and biological effects of four and a half LIM domain protein (FHL2) on granulosa cells in ovine.

  2020cites this paper
• The role of FHL2 in wound healing and inflammation

  2019cites this paper
• Analyses of MicroRNA and mRNA Expression Profiles Reveal the Crucial Interaction Networks and Pathways for Regulation of Chicken Breast Muscle Development

  2019cites this paper
• Molecular Analysis of a Short-term Model of β-Glucans-Trained Immunity Highlights the Accessory Contribution of GM-CSF in Priming Mouse Macrophages Response

  2017cites this paper
• Autophagy Induced FHL2 Upregulation Promotes IL-6 Production by Activating the NF-κB Pathway in Mouse Aortic Endothelial Cells after Exposure to PM2.5

  2017influential citation
• FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection

  2017cites this paper
• Etude des propriétés immunostimulantes de composés pariétaux de levure sur les macrophages murins et évaluation dans des modèles infectieux

  2016cites this paper
• Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE−/− Mice

  2015cites this paper
• Identification of Key Genes in the Response to Salmonella enterica Enteritidis, Salmonella enterica Pullorum, and Poly(I:C) in Chicken Spleen and Caecum

  2014cites this paper
• UvA-DARE ( Digital Academic Repository ) Crohn ’ s disease : Mucosal immunology and immune modulating therapy

  2014cites this paper
• Transcriptional Regulation of the Tumor Suppressor FHL2 by p53 in Human Kidney and Liver Cells

  2014cites this paper
• Age-related activation of MKK/p38/NF-κB signaling pathway in lung: from mouse to human.

  2014cites this paper
• Identification of FHL2‐Regulated Genes in Liver by Microarray and Bioinformatics Analysis

  2014influential citation
• LIM-Only Protein FHL2 Activates NF-κB Signaling in the Control of Liver Regeneration and Hepatocarcinogenesis

  2013cites this paper