Corticostriatopallidal Neuroprotection by Adenovirus-Mediated Ciliary Neurotrophic Factor Gene Transfer in a Rat Model of Progressive Striatal Degeneration

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.22-11-04478.2002PMID 12040055PMCID PMC6758779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice

  2001cited by this paper
• Neuroprotective Gene Therapy for Huntington’s Disease Using a Polymer Encapsulated BHK Cell Line Engineered to Secrete Human CNTF

  2000cited by this paper
• Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies.

  2000cited by this paper
• Long-term and significant correction of brain lesions in adult mucopolysaccharidosis type VII mice using recombinant AAV vectors.

  2000cited by this paper
• Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.

  2000cited by this paper
• Restoration of Cognitive and Motor Functions by Ciliary Neurotrophic Factor in a Primate Model of Huntington's Disease

  2000cited by this paper
• Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

  2000cited by this paper
• Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

  2000cited by this paper
• Therapeutic benefit of ciliary neurotrophic factor in progressive motor neuronopathy depends on the route of delivery

  1999cited by this paper
• Adenovirus-Mediated Transgene Expression in Nonhuman Primate Brain

  1999cited by this paper
• Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

  1998cited by this paper
• Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro.

  1998cited by this paper
• Extensive β-Glucuronidase Activity in Murine Central Nervous System after Adenovirus-Mediated Gene Transfer to Brain

  1998cited by this paper
• Connectivity and Convergence of Single Corticostriatal Axons

  1998cited by this paper
• Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain.

  1998cited by this paper
• Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population

  1997cited by this paper
• Adenovirus-mediated gene transfer to the brain: methodological assessment.

  1997cited by this paper
• Phenotypic Alteration of Astrocytes Induced by Ciliary Neurotrophic Factor in the Intact Adult Brain, As Revealed by Adenovirus-Mediated Gene Transfer

  1997cited by this paper
• Retrograde and anterograde labeling of cerebellar afferent projection by the injection of recombinant adenoviral vectors into the mouse cerebellar cortex

  1997influential reference
• Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration.

  1997cited by this paper
• Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid.

  1997cited by this paper
• A spatial and quantitative study of the striatopallidal connection in the monkey

  1996cited by this paper
• Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

  1996cited by this paper
• Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo

  1996cited by this paper
• Implants of Encapsulated Human CNTF-Producing Fibroblasts Prevent Behavioral Deficits and Striatal Degeneration in a Rodent Model of Huntington’s Disease

  1996influential reference
• Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies.

  1995influential reference
• Adenovirus gene transfer causes inflammation in the brain.

  1995cited by this paper
• Adenoviral vectors as functional retrograde neuronal tracers.

  1994cited by this paper
• Gene Transfer into Experimental Brain Tumors Mediated by Adenovirus, Herpes Simplex Virus, and Retrovirus Vectors

  1994cited by this paper
• In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.

  1994cited by this paper
• Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

  1994cited by this paper
• Glutamate‐induced calcium signaling in astrocytes

  1994cited by this paper
• Transfer of a foreign gene into the brain using adenovirus vectors

  1993cited by this paper
• An adenovirus vector for gene transfer into neurons and glia in the brain

  1993influential reference
• A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

  1993influential reference
• Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

  1993cited by this paper
• Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

  1993cited by this paper
• Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

  1993cited by this paper
• In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries.

  1993cited by this paper
• Adenoviral Vector as a Gene Delivery System into Cultured Rat Neuronal and Glial Cells

  1993cited by this paper
• Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat

  1992cited by this paper
• Striosomes and Matrisomes

  1991cited by this paper
• Unbiased stereological estimation of the number of neurons in the human hippocampus

  1990cited by this paper
• Efferent connections of the rostral portion of medial agranular cortex in rats.

  1987cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• AChE-stained horizontal sections of the rat brain in stereotaxic coordinates.

  1980cited by this paper

• The Suok 'ropewalking' test of rodent anxiety and sensorimotor disintegration:А 20-year summary of its application in neuroscience research.

  2025cites this paper
• Assessment of the Neuroprotective Potential of Glucose-Regulated Heat Shock Protein in a Model of Parkinson’s Disease in Rats

  2019cites this paper
• Assessment of the Neuroprotective Potential of Glucose-Regulated Heat Shock Protein in a Model of Parkinson’s Disease in Rats

  2019cites this paper
• New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease

  2018cites this paper
• Disease Modification Through Trophic Factor Delivery.

  2018cites this paper
• Evaluation de différentes stratégies thérapeutiques antisens pour le traitement de la maladie de Huntington

  2017cites this paper
• Simultaneous blockade of NMDA receptors and PARP‐1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3‐nitropropionic acid intoxicated mice: Evidences from memantine and 3‐aminobenzamide interventions

  2017cites this paper
• Huntington Disease: Linking Pathogenesis to the Development of Experimental Therapeutics

  2017cites this paper
• Nanotechnology-based drug-delivery systems releasing growth factors to the CNS: Focusing on neurodegenerative disorders

  2016cites this paper
• Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats

  2016cites this paper
• The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An in Vivo Multimodal Magnetic Resonance Imaging Study

  2015cites this paper
• Gene Therapy for Huntington’s Disease

  2015cites this paper
• Antioxidant gene therapy against neuronal cell death.

  2014cites this paper
• The 3‐NP Model of Striatal Neurodegeneration

  2014cites this paper
• Growth Hormone Deteriorates the Functional Outcome in an Experimental Model of Huntington’s Disease Induced by 3-Nitropionic Acid

  2013cites this paper
• Cellular Therapies for Huntington’s Disease

  2012cites this paper
• Nucleic Acid-Based Therapy Approaches for Huntington's Disease

  2012cites this paper
• Gene therapy for Huntington's disease.

  2012cites this paper
• pH as a Biomarker of Neurodegeneration in Huntington's Disease: A Translational Rodent-Human MRS Study

  2012cites this paper
• Altered microRNA regulation in Huntington's disease models.

  2011cites this paper
• Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington's disease: morphological and behavioral outcomes.

  2011cites this paper
• Viral vectors for neurotrophic factor delivery: a gene therapy approach for neurodegenerative diseases of the CNS.

  2010cites this paper
• Ciliary Neurotrophic Factor Protects Striatal Neurons against Excitotoxicity by Enhancing Glial Glutamate Uptake

  2010cites this paper
• Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression

  2010cites this paper
• Secretion of EGF-like domain of heregulinβ promotes axonal growth and functional recovery of injured sciatic nerve

  2010cites this paper
• Determination of the Role of Synapse Associated Protein 97 (SAP97) in the Normal and Parkinsonian Striatum

  2010cites this paper
• The effect of mitochondrial toxins on cytochrome c oxidase subunit IV isoforms and its consequences on mitochondrial function and neural cell survival

  2010cites this paper
• 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

  2010cites this paper
• Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

  2010cites this paper
• Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors

  2009cites this paper
• Développement d'un vecteur lentiviral ciblant les astrocytes et mise en application dans l'étude des transporteurs au glutamate GLAST et GLT-1

  2008cites this paper
• Cell therapy in Huntington disease.

  2008cites this paper
• AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment

  2008cites this paper
• Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons

  2008cites this paper
• Recombinant AAV viral vectors serotype 1, 2, and 5 mediate differential gene transfer efficiency in rat striatal fetal grafts.

  2008cites this paper
• Atorvastatin attenuates mitochondrial toxin‐induced striatal degeneration, with decreasing iNOS/c‐Jun levels and activating ERK/Akt pathways

  2008cites this paper
• STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage

  2008cites this paper
• Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease.

  2008cites this paper
• GENE AND CELLULAR TRANSPLANTATION THERAPIES FOR HUNTINGTON'S DISEASE

  2008cites this paper
• Modelling and treating Huntington’s disease: Generation of high-capacity adenovirus vectors to express normal and mutant huntingtin and to block huntingtin expression by short hairpin interference RNA

  2008cites this paper
• Malattia di Huntington: aspetti diagnostici attuali e applicazioni pratiche

  2008cites this paper
• Maladie de Huntington : aspects diagnostiques actuels et applications pratiques

  2008cites this paper
• Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults

  2007cites this paper
• Virally mediated knock-down of NR2 subunits ipsilateral to the deprived eye blocks ocular dominance plasticity

  2007cites this paper
• AAV-vector mediated gene delivery for Huntington's Disease : an investigative therapeutic study.

  2007influential citation
• Progress and Prospects: Gene Therapy Clinical Trials (Part 2)

  2007cites this paper
• 22 – Transplants of CNTF-producing Cells for the Treatment of Huntington's Disease

  2007cites this paper
• Progress and prospects: gene therapy clinical trials (part 2).

  2007cites this paper
• Recombinant AAV Viral Vectors Serotype 1, 2, and 5 Mediate Differential Gene Transfer Efficiency in Rat Striatal Fetal Grafts

  2007cites this paper
• Role of brain-derived neurotrophic factor in Huntington's disease.

  2007cites this paper
• IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats.

  2007cites this paper
• Cellular and molecular mechanisms involved in the selective vulnerability of striatal projection neurons in Huntington's disease.

  2006cites this paper
• Cell-Based Therapy for Huntington’s Disease

  2006cites this paper
• Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.

  2006influential citation
• Pharmaceutical, cellular and genetic therapies for Huntington's disease.

  2006cites this paper
• Ciliary Neurotrophic Factor Activates Astrocytes, Redistributes Their Glutamate Transporters GLAST and GLT-1 to Raft Microdomains, and Improves Glutamate Handling In Vivo

  2006cites this paper
• Neurotrophic Factors in Neurodegeneration

  2006cites this paper
• Caractérisation phénotypique et fonctionnelle de l'activation astrocytaire induite par transfert lentiviral du CNTF in vivo: Implications pour la survie neuronale

  2006cites this paper
• Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.

  2006cites this paper
• Huntington's disease: new frontiers for molecular and cell therapy.

  2005cites this paper
• Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells

  2005cites this paper
• 3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease

  2005cites this paper
• Gene therapy in the central nervous system

  2005cites this paper
• Dopamine and Glutamate in Huntington’s Disease

  2005cites this paper
• Minocycline in phenotypic models of Huntington's disease.

  2005cites this paper
• 3-NP-induced neurodegeneration studies in experimental models of Huntington's disease : apoptosis in Huntington's disease

  2005cites this paper
• Nouvelle approche multimodale et quantitative pour les études in vivo chez le petit animal : couplage de la $\beta$-MicroProbe aux techniques magnétiques et développement de fantômes de rat et de souris voxelisés

  2005cites this paper
• Clinical potential of minocycline for neurodegenerative disorders.

  2004cites this paper
• Insulin growth factor-1 protects against excitotoxicity in the rat striatum

  2004cites this paper
• Axonal transport of recombinant baculovirus vectors.

  2004cites this paper
• Cell therapy in Huntington’s disease

  2004cites this paper
• Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington's disease.

  2004cites this paper
• Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells1

  2004cites this paper
• Anterograde transport of neurotrophic factors

  2004influential citation
• Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms.

  2004cites this paper
• Invasive Strategies as Therapeutic Approaches for Central Nervous System Diseases

  2004cites this paper
• Cell therapy in Huntington’s disease

  2004cites this paper
• Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease

  2004cites this paper
• Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease.

  2004cites this paper
• Dose-dependent neurochemical and functional protection afforded by encapsulated CNTF-producing cells.

  2004cites this paper
• Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study

  2004cites this paper
• Neurotrophic factors in Huntington's disease.

  2004cites this paper
• Neuroprotective Effects of Encapsulated CNTF-Producing Cells in a Rodent Model of Huntington's Disease are Dependent on the Proximity of the Implant to the Lesioned Striatum1

  2004cites this paper
• Therapeutic strategies in Huntington’s disease

  2003cites this paper
• In Vivo Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration

  2003cites this paper
• Minocycline-induced activation of tetracycline-responsive promoter.

  2003cites this paper
• Calpain Is a Major Cell Death Effector in Selective Striatal Degeneration Induced In Vivo by 3-Nitropropionate: Implications for Huntington's Disease

  2003cites this paper
• Repeat expansion and autosomal dominant neurodegenerative disorders: consensus and controversy

  2003cites this paper
• Neurotrophic Factors

  2003cites this paper
• The Adenosine A1 Receptor Agonist Adenosine Amine Congener Exerts a Neuroprotective Effect against the Development of Striatal Lesions and Motor Impairments in the 3-Nitropropionic Acid Model of Neurotoxicity

  2002cites this paper