Modulation of caspases and their non‐apoptotic functions by Legionella pneumophila

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cellular Microbiology

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1462-5822.2009.01401.xPMID 19863553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.

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  2009cited by this paper
• The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

  2009cited by this paper
• IL-33 raises alarm.

  2009cited by this paper
• Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

  2009cited by this paper
• Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response

  2009cited by this paper
• Human Caspases: Activation, Specificity, and Regulation*

  2009influential reference
• Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

  2009cited by this paper
• The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

  2009cited by this paper
• The Jekyll and Hyde functions of caspases.

  2009cited by this paper
• HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

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• AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

  2009cited by this paper
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  2009cited by this paper
• The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.

  2009cited by this paper
• Innate immunity to pathogens: diversity in receptors for microbial recognition

  2009cited by this paper
• The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

  2009influential reference
• Restriction of Legionella pneumophila Replication in Macrophages Requires Concerted Action of the Transcriptional Regulators Irf1 and Irf8 and Nod-Like Receptors Naip5 and Nlrc4

  2009cited by this paper
• Rapid Pathogen-Induced Apoptosis: A Mechanism Used by Dendritic Cells to Limit Intracellular Replication of Legionella pneumophila

  2009influential reference
• Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

  2009cited by this paper
• A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors

  2009cited by this paper
• Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

  2008cited by this paper
• Host cell processes that influence the intracellular survival of Legionella pneumophila

  2008influential reference
• Caspases in apoptosis and beyond

  2008influential reference
• Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

  2008influential reference
• A Hemidominant Naip5 Allele in Mouse Strain MOLF/Ei-Derived Macrophages Restricts Legionella pneumophila Intracellular Growth

  2008influential reference
• Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes *S

  2008influential reference
• Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone

  2008cited by this paper
• Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

  2007cited by this paper
• Host-Dependent Trigger of Caspases and Apoptosis by Legionella pneumophila

  2007cited by this paper
• Caspase‐1 inflammasomes in infection and inflammation

  2007cited by this paper
• Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila

  2007cited by this paper
• Altered Inflammatory Responses in TLR5-Deficient Mice Infected with Legionella pneumophila1

  2007cited by this paper
• Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model.

  2007cited by this paper
• Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family

  2007influential reference
• Anti‐apoptotic signalling by the Dot/Icm secretion system of L. pneumophila

  2007cited by this paper
• What are caspases 3 and 7 doing upstream of the mitochondria?

  2006cited by this paper
• Induction of apoptosis by Legionella pneumophila in mammalian cells requires the mitochondrial pathway for caspase activation.

  2006influential reference
• Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf*

  2006cited by this paper
• A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death

  2006cited by this paper
• Role of Toll-Like Receptor 9 in Legionella pneumophila-Induced Interleukin-12 p40 Production in Bone Marrow-Derived Dendritic Cells and Macrophages from Permissive and Nonpermissive Mice

  2006cited by this paper
• Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

  2006cited by this paper
• Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

  2006cited by this paper
• The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

  2006influential reference
• NF-κB translocation prevents host cell death after low-dose challenge by Legionella pneumophila

  2006influential reference
• The newest interleukins: recent additions to the ever-growing cytokine family.

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• Caspase‐1‐dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

  2006cited by this paper
• Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

  2006influential reference
• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

  2006cited by this paper
• Naip5/Birc1e and susceptibility to Legionella pneumophila.

  2005cited by this paper
• The Structure of RalF, an ADP-ribosylation Factor Guanine Nucleotide Exchange Factor from Legionella pneumophila, Reveals the Presence of a Cap over the Active Site*

  2005cited by this paper
• Incomplete Activation of Macrophage Apoptosis during Intracellular Replication of Legionella pneumophila

  2005influential reference
• Vital functions for lethal caspases

  2005cited by this paper
• Autophagy is an immediate macrophage response to Legionella pneumophila

  2005cited by this paper
• Components of the Legionella pneumophila Flagellar Regulon Contribute to Multiple Virulence Traits, Including Lysosome Avoidance and Macrophage Death

  2005cited by this paper
• Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells

  2005cited by this paper
• Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.

  2005cited by this paper
• Cell biology of the intracellular infection by Legionella pneumophila.

  2004influential reference
• Macrophages from Mice with the Restrictive Lgn1 Allele Exhibit Multifactorial Resistance to Legionella pneumophila

  2004cited by this paper
• Toll-like receptors in innate immunity.

  2004cited by this paper
• Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.

  2004cited by this paper
• Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer.

  2004cited by this paper
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  2004influential reference
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  2004cited by this paper
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  2004cited by this paper
• Human Caspase-7 Activity and Regulation by Its N-terminal Peptide*

  2003cited by this paper
• Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

  2003cited by this paper
• Phagosome Maturation: A Few Bugs in the System

  2003cited by this paper
• Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

  2003influential reference
• The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype.

  2003cited by this paper
• Caspases and apoptosis.

  2002influential reference
• The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

  2002cited by this paper
• The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

  2002cited by this paper
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  2002cited by this paper
• Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.

  2001cited by this paper
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  2000cited by this paper
• The Neuronal Apoptosis Inhibitory Protein (Naip) Is Expressed in Macrophages and Is Modulated After Phagocytosis and During Intracellular Infection with Legionella pneumophila1

  2000cited by this paper
• From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens.

  2000cited by this paper
• Human Rabaptin-5 Is Selectively Cleaved by Caspase-3 during Apoptosis*

  1999cited by this paper
• The proteolytic procaspase activation network: an in vitro analysis

  1999cited by this paper
• Expression of Legionella pneumophilaVirulence Traits in Response to Growth Conditions

  1998cited by this paper
• Conjugative transfer by the virulence system of Legionella pneumophila.

  1998cited by this paper
• Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

  1998cited by this paper
• How is the intracellular fate of the Legionella pneumophila phagosome determined?

  1998cited by this paper
• Caspases: key mediators of apoptosis.

  1998cited by this paper
• Association of Legionella pneumophila with the macrophage endoplasmic reticulum

  1995cited by this paper
• Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene

  1994cited by this paper
• Intracellular survival by Legionella.

  1994cited by this paper
• The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes

  1983cited by this paper

• Structure and expression kinetics of Piscirickettsia salmonis sdhA during infection of Atlantic salmon macrophage-like cells.

  2025cites this paper
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  2022cites this paper
• Knowledge to Predict Pathogens: Legionella pneumophila Lifecycle Systematic Review Part II Growth within and Egress from a Host Cell

  2022influential citation
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  2021cites this paper
• Pyroptotic and non‐pyroptotic effector functions of caspase‐11

  2020cites this paper
• Evolution of the Arsenal of Legionella pneumophila Effectors To Modulate Protist Hosts

  2018cites this paper
• Knowledge to Predict Pathogens: Legionella pneumophila Lifecycle Critical Review Part I Uptake into Host Cells

  2018cites this paper
• Inflammasome biology taught by Legionella pneumophila

  2017cites this paper
• Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin

  2017cites this paper
• The regulation of acute immune responses to the bacterial lung pathogen Legionella pneumophila

  2017cites this paper
• The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages

  2016cites this paper
• Inflammasome Recognition and Regulation of the Legionella Flagellum.

  2016cites this paper
• Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.

  2016cites this paper
• Selective Requirement of the Shikimate Pathway of Legionella pneumophila for Intravacuolar Growth within Human Macrophages but Not within Acanthamoeba

  2015cites this paper
• Selective requirement of the shikimate pathway of Legionella pneumophila for 1 intra-vacuolar growth within human macrophages but not Acanthamoeba 2 3 1

  2015cites this paper
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  2015cites this paper
• The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?

  2015cites this paper
• Complete and Ubiquitinated Proteome of the Legionella-Containing Vacuole within Human Macrophages

  2014cites this paper
• Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages

  2014cites this paper
• The natural alternative: protozoa as cellular models for Legionella infection

  2014cites this paper
• Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection

  2013cites this paper
• Mycobacterium tuberculosis genes involved in regulation of host cell death.

  2013cites this paper
• Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages

  2013cites this paper
• From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts.

  2013influential citation
• Cellular microbiology and molecular ecology of Legionella–amoeba interaction

  2013cites this paper
• The cell death pathway induced by metal halide complexes of pyridine and derivative ligands in hepatocellular carcinoma cells - necrosis or apoptosis?

  2012cites this paper
• Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella.

  2012cites this paper
• Nucleotide-binding Oligomerization Domain Containing 2 Characterization and Function during Mycobacterium tuberculosis Infection of Human Macrophages

  2011cites this paper
• NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages

  2011cites this paper
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  2011cites this paper
• Legionella pneumophila Type II Secretion Dampens the Cytokine Response of Infected Macrophages and Epithelia

  2011cites this paper
• Manipulation of autophagy by bacteria for their own benefit

  2011cites this paper
• Legionella pneumophila Caused by Molecular Pathogenesis of Infections

  2010cites this paper
• Molecular Pathogenesis of Infections Caused by Legionella pneumophila

  2010cites this paper
• Replication of Legionella Pneumophila in Human Cells: Why are We Susceptible?

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• Asc-Dependent and Independent Mechanisms Contribute to Restriction of Legionella Pneumophila Infection in Murine Macrophages

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  2010cites this paper
• Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes*

  2010cites this paper
• Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.

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