Cannabinoid Receptors Couple to NMDA Receptors to Reduce the Production of NO and the Mobilization of Zinc Induced by Glutamate

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2013-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1089/ars.2012.5100PMID 23600761PMCID PMC3837442
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Psychological Stress-Induced Lower Serum Zinc and Zinc Redistribution in Rats

  2013cited by this paper
• Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia

  2012cited by this paper
• Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.

  2012cited by this paper
• GPCRs Promote the Release of Zinc Ions Mediated by nNOS/NO and the Redox Transducer RGSZ2 Protein

  2012cited by this paper
• Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.

  2012cited by this paper
• The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control

  2012cited by this paper
• The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor–glutamate NMDA receptor cross-regulation

  2011cited by this paper
• Intra-accumbal NMDA but not AMPA/kainate receptor antagonist attenuates WIN55,212-2 cannabinoid receptor agonist-induced antinociception in the basolateral amygdala in a rat model of acute pain.

  2011cited by this paper
• RGSZ2 Binds to the Neural Nitric Oxide Synthase PDZ Domain to Regulate Mu-Opioid Receptor-Mediated Potentiation of the N-Methyl-D-Aspartate Receptor-Calmodulin-Dependent Protein Kinase II Pathway

  2011cited by this paper
• Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity.

  2011influential reference
• Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn

  2010cited by this paper
• Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivoΔ9‐THC exposure‐impaired hippocampal synaptic plasticity

  2010cited by this paper
• Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells.

  2010cited by this paper
• Signaling Pathways from Cannabinoid Receptor-1 Activation to Inhibition of N-Methyl-d-Aspartic Acid Mediated Calcium Influx and Neurotoxicity in Dorsal Root Ganglion Neurons

  2009influential reference
• Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

  2009cited by this paper
• New therapy for neuropathic pain.

  2009cited by this paper
• Nitric Oxide in Health and Disease of the Nervous System

  2009cited by this paper
• Role of cannabis and endocannabinoids in the genesis of schizophrenia

  2009cited by this paper
• Roles of the endocannabinoid system in learning and memory.

  2009cited by this paper
• Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats.

  2008cited by this paper
• Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis

  2008cited by this paper
• PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior

  2008cited by this paper
• Cannabinoids for the treatment of neuropathic pain: clinical evidence.

  2008influential reference
• Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.

  2008cited by this paper
• Distribution and Expression of Protein Kinase C Interactive Protein (PKCI/HINT1) in Mouse Central Nervous System (CNS)

  2008cited by this paper
• Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors*

  2008cited by this paper
• Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?

  2008cited by this paper
• NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice.

  2007cited by this paper
• The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects

  2007cited by this paper
• Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.

  2007cited by this paper
• The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity.

  2007influential reference
• RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.

  2007cited by this paper
• Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

  2006cited by this paper
• Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity

  2006cited by this paper
• Neuromodulatory functions of the endocannabinoid system.

  2006cited by this paper
• Serum resistin increases in a postprandial state during liquid meal challenge test in healthy human subjects

  2006cited by this paper
• Risk for schizophrenia--broadening the concepts, pushing back the boundaries.

  2005cited by this paper
• Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

  2005cited by this paper
• Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined Immunochemical and Pharmacological Analysis

  2005cited by this paper
• Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.

  2005cited by this paper
• Protein kinase A‐dependent enhanced NMDA receptor function in pain‐related synaptic plasticity in rat amygdala neurones

  2005cited by this paper
• Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

  2005cited by this paper
• Prenatal exposure to the CB1 receptor agonist WIN 55,212-2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring.

  2005influential reference
• The neurobiology of zinc in health and disease

  2005cited by this paper
• Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors

  2004cited by this paper
• Zinc and Excitotoxic Brain Injury: A New Model

  2004cited by this paper
• Role of mPKCI, a novel mu-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphine-induced analgesia.

  2004cited by this paper
• Involvement of brain‐derived neurotrophic factor in cannabinoid receptor‐dependent protection against excitotoxicity

  2004cited by this paper
• Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury.

  2004influential reference
• Gene Expression of Metabolic Enzymes and a Protease Inhibitor in the Prefrontal Cortex Are Decreased in Schizophrenia

  2004cited by this paper
• Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury.

  2004cited by this paper
• Erratum: Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages (Molecular Pharmacology (2004) 66 (909-920))

  2004cited by this paper
• The Role of Several Kinases in Mice Tolerant to Δ9-Tetrahydrocannabinol

  2003cited by this paper
• Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors*

  2003cited by this paper
• CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

  2003cited by this paper
• Cannabinoids Decrease Corticostriatal Synaptic Transmission via an Effect on Glutamate Uptake

  2003cited by this paper
• The role of several kinases in mice tolerant to delta 9-tetrahydrocannabinol.

  2003cited by this paper
• Testing hypotheses about the relationship between cannabis use and psychosis.

  2003cited by this paper
• Regulation of Extracellular Signal-Regulated Kinase by Cannabinoids in Hippocampus

  2003cited by this paper
• The Role of Several Kinases in Mice Tolerant to (cid:1) 9 Tetrahydrocannabinol

  2003cited by this paper
• Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1

  2002cited by this paper
• Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord.

  2002cited by this paper
• Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study.

  2002cited by this paper
• [Glutaminergic hypothesis of schizophrenia: clinical research studies with ketamine].

  2001cited by this paper
• PKC and CaMKII dependent synaptic potentiation in cultured cerebral neurons.

  2001cited by this paper
• Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies.

  2001cited by this paper
• Ultrastructural Localization of the CB1 Cannabinoid Receptor in μ-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus

  2001cited by this paper
• Induction of Neuronal Apoptosis by Thiol Oxidation

  2000influential reference
• Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord.

  1999cited by this paper
• Ca2+-calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains.

  1999cited by this paper
• Internalization and Recycling of the CB1 Cannabinoid Receptor

  1999cited by this paper
• A light and electron microscopic study of the CB1 cannabinoid receptor in the primate spinal cord

  1999cited by this paper
• Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

  1998cited by this paper
• Nitric oxide in health and disease of the nervous system

  1997cited by this paper
• Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies*

  1997cited by this paper
• NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release.

  1995cited by this paper
• Alternatively spliced isoforms of the NMDARI receptor subunit.

  1995cited by this paper
• Effects of NMDA receptor blockade and nitric oxide synthase inhibition on the acute and chronic actions of delta 9-tetrahydrocannabinol in mice.

  1994cited by this paper
• Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid.

  1991cited by this paper

• Recent Preclinical Evidence on Phytocannabinoids in Neurodegenerative Disorders: A Focus on Parkinson’s and Alzheimer’s Disease

  2025cites this paper
• Implications of the mitochondrial CB1 receptor in the brain: from mitochondrial dysfunction to neuroprotection

  2025cites this paper
• Cannabinoid CB1 Receptor Activation Mitigates N‑Methyl‑d‑aspartate Receptor-Mediated Neurotoxicity.

  2025cites this paper
• Endocannabinoid and nitric oxide interactions in the brain.

  2025cites this paper
• Foxq1 activates CB2R with oleamide to alleviate POCD

  2024cites this paper
• The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy

  2024cites this paper
• Endocannabinoid levels in plasma and neurotransmitters in the brain: a preliminary report on patients with a psychotic disorder and healthy individuals

  2024cites this paper
• Activation of ventral hippocampal CB1 receptors inhibits ketamine-induced anxiogenic-like behavior: Alteration of BDNF/c-Fos levels in the mouse hippocampus.

  2023cites this paper
• Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain

  2023cites this paper
• Cannabinoids in Medicine: A Multifaceted Exploration of Types, Therapeutic Applications, and Emerging Opportunities in Neurodegenerative Diseases and Cancer Therapy

  2023cites this paper
• The Many Faces of Histidine Triad Nucleotide Binding Protein 1 (HINT1).

  2023cites this paper
• Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction.

  2023cites this paper
• Oleamide Reduces Mitochondrial Dysfunction and Toxicity in Rat Cortical Slices Through the Combined Action of Cannabinoid Receptors Activation and Induction of Antioxidant Activity

  2022cites this paper
• Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson’s Disease: A Novel and Futuristic Approach

  2022cites this paper
• Targeting mediodorsal thalamic CB1 receptors to inhibit dextromethorphan-induced anxiety/exploratory-related behaviors in rats: The post-weaning effect of exercise and enriched environment on adulthood anxiety.

  2022cites this paper
• Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions

  2022influential citation
• Cannabidiol, but Not Δ9-Tetrahydrocannabinol, Has Strain- and Genotype-Specific Effects in Models of Psychosis

  2022cites this paper
• Overview of the Endocannabinoid System and Endocannabinoidome

  2022cites this paper
• The Endocannabinoidome in Neuropsychiatry: Opportunities and Potential Risks.

  2021cites this paper
• The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain

  2021cites this paper
• Oxidative Stress and Neuronal Injury After Cannabis and Ketamine Administration

  2021cites this paper
• The Endocannabinoid System in the Central Nervous System: Emphasis on the Role of the Mitochondrial Cannabinoid Receptor 1 (mtCB1R)

  2021cites this paper
• Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP)

  2021cites this paper
• The Pharmacology of Cannabinoids

  2021cites this paper
• The Use of Cannabidiol in Treating Psychiatric Disorders: A Systematic Review

  2021cites this paper
• Mini-review: The therapeutic role of cannabinoids in neuroHIV

  2021cites this paper
• Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions

  2020cites this paper
• The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease.

  2020cites this paper
• The role of HINT1 protein in morphine addiction: An animal model‐based study

  2020cites this paper
• Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

  2020cites this paper
• Neuroprotection by Micronutrients and Cannabidiol (CBD) in Neurodegenerative Diseases

  2020influential citation
• Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons.

  2020cites this paper
• Cannabinoid Receptors: An Update on Cell Signaling, Pathophysiological Roles and Therapeutic Opportunities in Neurological, Cardiovascular, and Inflammatory Diseases

  2020cites this paper
• Endogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophrenia

  2020cites this paper
• Antinociceptive and antidepressive efficacies of the combined ineffective doses of S-ketamine and URB597

  2019cites this paper
• WIN 55,212-2 Reverted Pilocarpine-Induced Status Epilepticus Early Changes of the Interaction among 5-HT2C/NMDA/CB1 Receptors in the Rat Hippocampus.

  2019cites this paper
• Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.

  2019cites this paper
• A Cannabinoid Receptor-Mediated Mechanism Participates in the Neuroprotective Effects of Oleamide Against Excitotoxic Damage in Rat Brain Synaptosomes and Cortical Slices

  2019cites this paper
• Novel Optogenetic Approaches in Epilepsy Research

  2019cites this paper
• Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

  2019cites this paper
• Agonists of CB1 and NMDA receptors decrease the toxic effect of organophosphorus compound paraoxon on PC12 cells

  2019cites this paper
• Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis

  2019cites this paper
• Cannabinoids, TRPV and nitric oxide: the three ring circus of neuronal excitability

  2019cites this paper
• Anticonvulsant and Neuroprotective Effects of Cannabidiol During the Juvenile Period

  2018influential citation
• Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice

  2018cites this paper
• The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation

  2018cites this paper
• Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors

  2018cites this paper
• Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

  2018cites this paper
• Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

  2018cites this paper
• Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats

  2018cites this paper
• Disciplinare BIO / 09-Fisiologia ROLE OF NITRIC OXIDE / cGMP PATHWAY IN CANNABINOID MODULATION OF PAROXYSMAL PHENOMENA

  2017cites this paper
• Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

  2017cites this paper
• Endocannabinoid activation of CB1 receptors contributes to long‐lasting reversal of neuropathic pain by repetitive spinal cord stimulation

  2017cites this paper
• Schizophrenia and depression, two poles of endocannabinoid system deregulation

  2017cites this paper
• HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator

  2017cites this paper
• Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

  2017cites this paper
• Human Laboratory Studies on Cannabinoids and Psychosis.

  2016cites this paper
• Cannabinoids: Glutamatergic Transmission and Kynurenines.

  2016cites this paper
• Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

  2016influential citation
• Hint1 gene deficiency enhances the supraspinal nociceptive sensitivity in mice

  2016cites this paper
• Cannabinoid–glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors

  2016cites this paper
• HINT1 is involved in the behavioral abnormalities induced by social isolation rearing.

  2015cites this paper
• Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat.

  2015cites this paper
• Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection

  2015cites this paper
• The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

  2015influential citation
• The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control

  2015cites this paper
• Opioid Receptors

  2015cites this paper
• Regulation of neuronal communication by G protein‐coupled receptors

  2015cites this paper
• Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats.

  2015cites this paper
• Detecting zinc release induced by mu-opioid receptor agonists in brain slices.

  2015cites this paper
• HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia.

  2015cites this paper
• Inhibition of endogenous cannabinoid breakdown in the presence of verapamil on learning and memory in a rat

  2014cites this paper
• Why sigma-1 receptor dysfunction might confer vulnerability to cannabis-induced psychosis.

  2014cites this paper
• The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia

  2014cites this paper
• The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.

  2014influential citation
• HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity

  2013influential citation
• Psychological Stress-Induced Lower Serum Zinc and Zinc Redistribution in Rats

  2013cites this paper