RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Cell Science

• Publication date

  2014-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.138891PMID 24634510
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14

  2014cited by this paper
• c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.

  2013cited by this paper
• RNF111-dependent neddylation activates DNA damage-induced ubiquitination.

  2013influential reference
• RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

  2012cited by this paper
• A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

  2012cited by this paper
• RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

  2012influential reference
• RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.

  2012cited by this paper
• Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

  2011cited by this paper
• Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

  2011cited by this paper
• TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers.

  2011cited by this paper
• Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

  2010cited by this paper
• Regulation of the Polycomb protein RING1B ubiquitination by USP7.

  2010cited by this paper
• E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

  2009cited by this paper
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

  2009cited by this paper
• RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

  2009influential reference
• Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

  2008cited by this paper
• A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

  2008cited by this paper
• Specific inhibition of Mdm2-mediated neddylation by Tip60

  2008cited by this paper
• The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

  2008cited by this paper
• Ribosomal proteins are targets for the NEDD8 pathway

  2008cited by this paper
• Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.

  2008cited by this paper
• Regulation of mitotic exit by the RNF8 ubiquitin ligase

  2008cited by this paper
• p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53

  2008cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007influential reference
• Hetero-oligomerization with MdmX Rescues the Ubiquitin/Nedd8 Ligase Activity of RING Finger Mutants of Mdm2*

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• FBXO11 Promotes the Neddylation of p53 and Inhibits Its Transcriptional Activity*

  2007cited by this paper
• The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.

  2007cited by this paper
• Modification of proteins by ubiquitin and ubiquitin-like proteins.

  2006cited by this paper
• Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

  2006cited by this paper
• A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.

  2006cited by this paper
• Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications.

  2006cited by this paper
• The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

  2006cited by this paper
• Neddylating the Guardian: Mdm2 Catalyzed Conjugation of Nedd8 to p53

  2004cited by this paper
• Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system.

  2004cited by this paper
• Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation*

  2004cited by this paper
• Nedd8 on cullin: building an expressway to protein destruction

  2004influential reference
• Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.

  2004influential reference
• Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

  2002cited by this paper
• The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

  2001cited by this paper
• NEDD8 recruits E2‐ubiquitin to SCF E3 ligase

  2001influential reference
• The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis.

  2000cited by this paper
• Covalent modifier NEDD8 is essential for SCF ubiquitin‐ligase in fission yeast

  2000cited by this paper
• A Dominant-negative UBC12 Mutant Sequesters NEDD8 and Inhibits NEDD8 Conjugation in Vivo *

  2000cited by this paper
• There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation.

  1998cited by this paper
• A novel protein modification pathway related to the ubiquitin system

  1998cited by this paper
• Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex.

  1998cited by this paper
• Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein*

  1997cited by this paper
• The international centre for genetic engineering and biotechnology

  1987cited by this paper
• Amino-terminal sequence identity of ubiquitin and the nonhistone component of nuclear protein A24.

  1977cited by this paper
• Non-histone chromosomal proteins. Their isolation and role in determining specificity of transcription in vitro.

  1975cited by this paper
• Isolation and characterization of protein A24, a "histone-like" non-histone chromosomal protein.

  1975cited by this paper

• Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer

  2025cites this paper
• Neddylation and MASLD: From Pathophysiology to Therapy

  2025cites this paper
• Protein neddylation and its role in health and diseases

  2024cites this paper
• An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway

  2024cites this paper
• LncRNAs and the Cancer Epigenome: Mechanisms and Therapeutic Potential.

  2024cites this paper
• Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases

  2024cites this paper
• A Novel Approach to Explore Metabolic Diseases: Neddylation.

  2024cites this paper
• Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics

  2024cites this paper
• E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

  2024cites this paper
• Deciphering the interplay of histone post-translational modifications in cancer: Co-targeting histone modulators for precision therapy.

  2024cites this paper
• Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma

  2024cites this paper
• Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities.

  2023cites this paper
• Discovery of neddylation E2s inhibitors with therapeutic activity

  2023cites this paper
• PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα

  2022cites this paper
• Mixed in chains: NEDD8 polymers in the Protein Quality Control system.

  2022cites this paper
• Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way

  2021cites this paper
• Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability.

  2021cites this paper
• Role of neddylation in neurological development and diseases

  2021cites this paper
• Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.

  2021cites this paper
• Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis

  2021cites this paper
• Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition

  2021cites this paper
• Role of NEDD8 and neddylation dynamics in DNA damage response

  2021cites this paper
• Ubiquitylation in DNA double-strand break repair.

  2021cites this paper
• GGVD: A goat genome variation database for tracking the dynamic evolutionary process of selective signatures and ancient introgressions.

  2021cites this paper
• Targeting neddylation E2s: a novel therapeutic strategy in cancer

  2021influential citation
• Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.

  2020cites this paper
• A predicted NEDD8 conjugating enzyme gene identified as a Capsicum candidate Rf gene using bulk segregant RNA sequencing

  2020cites this paper
• Diverse and pivotal roles of neddylation in metabolism and immunity

  2020cites this paper
• Phenotype Heterogeneity in 3q29 Microduplication Syndrome

  2020cites this paper
• UBC12‐mediated SREBP‐1 neddylation worsens metastatic tumor prognosis

  2020cites this paper
• Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

  2020cites this paper
• CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response.

  2020cites this paper
• Old and New Concepts in Ubiquitin and NEDD8 Recognition

  2020cites this paper
• Ubiquitination and Ubiquitin-Like Modifications in Multiple Myeloma: Biology and Therapy

  2020cites this paper
• Development of Nanobodies as first-in-class inhibitors for the NEDP1 deNEDDylating enzyme

  2020cites this paper
• Integrative analysis of the nuclear proteome in Pinus radiata reveals thermopriming coupled to epigenetic regulation

  2019cites this paper
• NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage.

  2019cites this paper
• Targeting epigenetics for cancer therapy

  2019cites this paper
• The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity

  2019cites this paper
• New Insights into the Mechanisms Underlying NEDD8 Structural and Functional Specificities

  2019cites this paper
• Regulation of DNA damage-induced ATM activation by histone modifications

  2019cites this paper
• The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

  2019cites this paper
• Inflammation-associated genomic instability in cancer

  2019cites this paper
• Ubiquitin and the DNA double-strand break repair pathway

  2019cites this paper
• Epigenetic modifications of histones in cancer

  2019cites this paper
• Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response

  2019cites this paper
• Genetic instability upon the loss of the tumour suppressor folliculin (FLCN)

  2019cites this paper
• Targeting Chromatin Remodeling for Cancer Therapy

  2019cites this paper
• Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly(ADP-ribose) polymerase–dependent manner and regulates the DNA damage response

  2018cites this paper
• A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.

  2018cites this paper
• Proteomics and bioinformatics analyses identify novel cellular roles outside mitochondrial function for human miro GTPases

  2018cites this paper
• The Impact of Post-Translational Regulation of Histone on Cancer Metastasis and Cancer Chemoresistance

  2017cites this paper
• Ubiquitin-like modifications in the DNA damage response.

  2017cites this paper
• An E 2-guided E 3 Screen Identifies the RNF 17-UBE 2 U Pair as Regulator of the Radiosensitivity , Immunodeficiency , Dysmorphic Features , and Learning Difficulties ( RIDDLE ) Syndrome Protein RNF 168 *

  2017cites this paper
• Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

  2017cites this paper
• MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination.

  2017cites this paper
• NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage

  2017cites this paper
• Targeting NEDD8 Conjugation for Therapeutic Gain in Acute Lymphoblastic Leukemia

  2017cites this paper
• The ubiquitin family meets the Fanconi anemia proteins.

  2016cites this paper
• An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168*

  2016cites this paper
• Itch promotes the neddylation of JunB and regulates JunB-dependent transcription.

  2016cites this paper
• An E 2-guided E 3 screen identifies the RNF 17-UBE 2 U pair as regulator of the RIDDLE Syndrome Protein RNF 168

  2016cites this paper
• Semisynthetic UbH2A reveals different activities of deubiquitinases and inhibitory effects of H2A K119 ubiquitination on H3K36 methylation in mononucleosomes.

  2016cites this paper
• Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

  2016cites this paper
• Ubiquitylation, neddylation and the DNA damage response

  2015cites this paper
• Prediction of neddylation sites from protein sequences and sequence-derived properties

  2015cites this paper
• Promoting Genome Stability via Multiple DNA Repair Pathways

  2015influential citation
• The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair

  2015cites this paper
• Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic.

  2015cites this paper
• Deubiquitinating enzymes as oncotargets

  2015cites this paper
• Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

  2015cites this paper
• Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

  2015cites this paper
• University of Birmingham E3 ligases

  year unknowncites this paper